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Cat. No.	Product Name	Target	Signaling Pathways
T14778	BRD6989	IL Receptor; CDK; Interleukin	Cell Cycle/Checkpoint; Immunology/Inflammation
	BRD6989 是天然产物皮质抑素 A 的类似物，可抑制CDK8并上调IL-10，抑制重组 CDK8 或 CDK19 复合物的激酶活性。它选择性结合 CDK8 复合物，IC50约为 200 nM。
T8430	Senexin B 4-[[2-[6-[(4-甲基-1-哌嗪基)羰基]-2-萘基]乙基]氨基]-6-喹唑啉甲腈	CDK	Cell Cycle/Checkpoint
	Senexin B 是一种有效的选择性 CDK8/19 抑制剂（CDK8 和 CDK19，Kd 分别为 140 nM 和 80 nM）。
T5673	Senexin A	CDK	Cell Cycle/Checkpoint
	Senexin A 是一种有效且选择性的 CDK8 抑制剂，它还抑制 CDK19，Kd 值分别为0.83μM 和0.31μM。
T10744	SEL120-34A	CDK	Cell Cycle/Checkpoint
	SEL120-34A 是CDK8的选择性和ATP 竞争性抑制剂，对CDK8/CycC、CDK19/CycC 和CDK9/cycT 的IC50s 为4.4 nM、10.4 nM 和1070 nM。SEL120-34A 具有抗肿瘤活性。
T10744L	SEL120-34A HCl	CDK	Cell Cycle/Checkpoint
	SEL120-34A HCl 是一种可口服的，选择性的，ATP-竞争性的CDK8抑制剂，具有抗肿瘤活性，对 CDK8/CycC 和 CDK19/CycC 的IC50值分别为 4.4 nM 和 10.4 nM。
T8378	AS2863619	CDK; STAT	Cell Cycle/Checkpoint; JAK/STAT signaling; Stem Cells
	AS2863619 是一种口服的细胞周期蛋白依赖性激酶 8 和CDK19抑制剂，抑制CDK8/19可增强STAT5的激活，从而激活 Foxp3 基因。它可将抗原特异性效应子/记忆 T 细胞转换为 Foxp3+调节性 T 细胞，以研究各种免疫疾病。
T14907	CCT251545	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	CCT251545 是一种有效的、具有口服活性的WNT 抑制剂，在 7dF3 细胞中对 WNT 抑制作用的IC50值为 5 nM。它是选择性化学探针，用于探索 CDK8 和 CDK19 在人类疾病中的作用。
T10739	CDK8/19-IN-1	CDK	Cell Cycle/Checkpoint
	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T81137	SNX7886	PROTACs	PROTAC
	SNX7886为高效CDK8/19蛋白降解剂，在293细胞中可分别降解CDK8与CDK19至90%及80%。
T70098	CDK8-IN-18
	CDK8-IN-18, also known as ZINC584617986, is a potent and selective inhibitor of CDK8, also modulating CDK19.
T23909	Cortistatin A Cortistatin-A
	Cortistatin A is a potent and selective mediator-associated kinase CDK8 and its paralogue CDK19 inhibitor.
T14901	CCT-251921	CDK	Cell Cycle/Checkpoint
	CCT-251921是一种有口服活性的选择性CDK8抑制剂；IC50值为2.3 nM。
T24811	SNX2-1-108 SNX-21108,SNX21108,SNX 21108
	SNX2-1-108 is a selective CDK8 and CDK19 inhibitor.
T10382	AS2863619 free base	CDK	Cell Cycle/Checkpoint
	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.
T68758	UNC10112785
	UNC10112785 is a novel potent inhibitor of CDK8, CDK19, and CDK9 with IC50 at 1.05, 2.67, and 19.9 nM, respectively, causing MYC loss through both transcriptional and posttranslational mechanisms, and suppressing PDAC anchorage-dependent and anchorage-independent growth, inducing the substantial loss of MYC protein in both two-dimensional (2D) and 3D cell cultures.
T13743	JH-XI-10-02	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	JH-XI-10-02 causes proteasomal degradation, does not affect CDK8 mRNA levels. JH-XI-10-02 shows no effect on CDK19. JH-XI-10-02 is a potent and selective degrader of CDK8, with an IC50 of 159 nM, based on PROTAC.
T22633	CCT251545 analogue, Compound 51	Others	Others
	CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1 nM and 5.6 nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastri
T40280	JH-XVI-178
	JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with favorable pharmacokinetic attributes, including low clearance and moderate oral bioavailability.

化合物

Cat.No: T14778

Target: IL Receptor, CDK, Interleukin

Cat.No: T8430

Synonym: 4-[[2-[6-[(4-甲基-1-哌嗪基)羰基]-2-萘基]乙基]氨基]-6-喹唑啉甲腈

Target: CDK

Cat.No: T5673

Target: CDK

Cat.No: T10744

Target: CDK

Cat.No: T10744L

Target: CDK

Cat.No: T8378

Target: CDK, STAT

Cat.No: T14907

Target: Wnt/beta-catenin

Cat.No: T10739

Target: CDK

Cat.No: T81137

Target: PROTACs

Cat.No: T70098

Cat.No: T23909

Synonym: Cortistatin-A

Cat.No: T14901

Target: CDK

Cat.No: T24811

Synonym: SNX-21108,SNX21108,SNX 21108

AS2863619 free base

Cat.No: T10382

Target: CDK

Cat.No: T68758

Cat.No: T13743

Target: EGFR

CCT251545 analogue, Compound 51

Cat.No: T22633

Target: Others

Cat.No: T40280

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