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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T73865 | (Rac)-BIO8898 | ||
(Rac)-BIO8898 是一种 CD40-CD154共刺激相互作用抑制剂。(Rac)-BIO8898 抑制 CD154 与 CD40-Ig 结合,IC50为 25 μM。 | |||
T73866 |
BIO8898
|
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BIO8898 是一种有效的 CD40-CD154抑制剂。BIO8898 抑制可溶性 CD40L 与 CD40-Ig 的结合,IC50值为 25 µM。BIO8898 抑制 CD40L 诱导的细胞凋亡(apoptosis)。 | |||
T30669 |
C.I. Mordant Brown 1
NSC-326197,NSC 326197,NSC326197 |
||
C.I. Mordant Brown 1 是一种偶氮染料,λmax 为 373 nm、487 nm (2nd)。C.I. Mordant Brown 1 也可以抑制CD40-CD154 共刺激蛋白-蛋白互作。 | |||
T76834 | Toralizumab | ||
Toralizumab (IDEC-131) 是一种针对 CD40L (CD154)的人源化单克隆抗体 (mAb),由人 γ1 重链和人 kappa 轻链组成。Toralizumab 特异性结合 T 细胞上的人 CD40L,从而阻止 CD40信号传导。Toralizumab 是一种免疫抑制剂,具有用于活跃的系统性红斑狼疮 (SLE) 研究的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-02022 |
CD40 Ligand Protein, Human, Recombinant (hFc)
HIGM1,IGM,gp39,CD40L,T-BAM,CD40 ligand, |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession number is P29965. | |||
TMPY-05646 |
CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated
CD154,TRAP,CD40 ligand,gp39,h... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 44.7 kDa and the accession number is P29965. | |||
TMPY-01758 |
CD40 Ligand Protein, Human, Recombinant (His)
IMD3,hCD40L,CD40L,TRAP,TNFSF5,IGM,HIGM1,gp... |
Human | E. coli |
CD40 Ligand Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P29965. | |||
TMPK-00154 |
CD40 Ligand Protein (Primary Amine Labeling), Human, Recombinant (His & Flag), Biotinylated
IMD3,TNFSF5IMD3,TRAP,CD40LIGM,CD40 Ligand,... |
Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. CD40 Ligand Prote... | |||
TMPH-02439 |
CD40L Protein, Rhesus macaque, Recombinant (His)
CD40L,TNFSF5,CD40LG,CD154 |
Rhesus | E. coli |
CD40L Protein, Rhesus macaque, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 28.5 kDa and the accession number is P63304. | |||
TMPK-00860 |
CD40 Ligand Protein, Mouse, Recombinant (monomeric hFc)
IMD3,CD40LG,CD40L,IGM,TRAP,T-BAM,gp39,HIGM... |
Mouse | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. CD40 Ligand Prote... | |||
TMPY-02793 |
CD40 Ligand Protein, Mouse, Recombinant (hFc)
gp39,CD40 ligand,IGM,Cd40l,CD40-L... |
Mouse | HEK293 Cells |
CD40 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.4 kDa and the accession number is P27548. | |||
TMPK-01398 |
CD40 Ligand Trimer Protein, Human, Recombinant (hFc)
CD40 Ligand,CD40LIGM,IGM,gp39,TNFSF5,TRAP,... |
Human | HEK293 Cells |
CD40 ligand or CD40L, also called CD154, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells. | |||
TMPY-06687 |
CD40 Ligand Protein, Mouse, Recombinant (His)
IGM,IMD3,TRAP,Ly62,CD40-L,Tnfsf5,CD154... |
Mouse | HEK293 Cells |
CD40 Ligand Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.37 kDa and the accession number is P27548. | |||
TMPJ-00150 |
CD40 Ligand Protein, Human, Recombinant (Mammalian)
CD40LG,Tumor Necrosis Factor Ligand Superfamily Mem... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (Mammalian) is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-18 KDa and the accession number is P29965. | |||
TMPJ-00151 |
CD40 Ligand Protein, Human, Recombinant
CD40LG,CD40 Ligand,TRAP,TNF-Related Activa... |
Human | E. coli |
CD40 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is P29965. | |||
TMPJ-00152 |
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated
CD40 Ligand,TNF-Related Activation Protein,CD |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-6xHis-Avi tag. The predicted molecular weight is 23-28 KDa and the accession number is P29965. | |||
TMPJ-00153 |
CD40 Ligand Protein, Human, Recombinant (His & Flag)
CD40LG,Tumor Necrosis Factor Ligand Superfamily Mem... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 19-24 KDa and the accession number is P29965. | |||
TMPK-00170 |
CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated
CD40 antigen, TNFRSF5,CD40 molecule,C... |
Human | HEK293 Cells |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. | |||
TMPJ-00920 |
CD40 Ligand Protein, Mouse, Recombinant (aa 112-260, His)
TNFSF5,Tumor necrosis factor ligand superfamily member 5, |
Mouse | HEK293 Cells |
CD40 Ligand, also known as TNFSF5, CD154, is a type II transmembrane glycoprotein member of the TNF superfamily. Mature mouse CD40 Ligand consists of a 22 amino acid (aa) cytoplasmic domain, a transmembrane segment, and a 214 aa extracellular region. CD40 Ligand is expressed as a homotrimer on platelets and activated T cells and B cells. It is upregulated following stimulation of basophils, eosinophils, fibroblasts, mast cells, monocytes, natural killer cells, vascular endothelial cells, and sm... |