Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10714 | CCR5 antagonist 1 | HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
CCR5 antagonist 1 is a CCR5 antagonist extracted from WO 2004054974 A2. It can inhibit HIV replication. | |||
T6016 |
Maraviroc
Celsentri,马拉维若,UK-427857,Selzentry |
HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Maraviroc (Selzentry) 是一种 C-C 趋化因子受体 5 拮抗剂,具有抑制HIV 的活性。 | |||
TQ0297 |
Cenicriviroc
TAK-652,TBR-652 |
HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Cenicriviroc (TAK-652) 是一种可口服的CCR2/CCR5拮抗剂,可抑制 HIV-1 和 HIV-2,具有抗炎、抗感染作用。 | |||
T71665 |
INCB-9471
|
HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
INCB-9471 是一种 CCR5 拮抗剂,具有抗HIV活性,抑制 HIV-1 gp120 之间的相互作用。 | |||
T7499 |
TAK-779
Takeda 779 |
HIV Protease; CXCR; CCR | Autophagy; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
TAK-779 (Takeda 779) 是一种非肽类CCR5和CXCR3 拮抗剂,对CCR5的Ki 值为 1.1 nM,并选择性抑制R5 HIV-1。 | |||
T3435 |
Vicriviroc maleate
维立韦罗马来酸盐,SCH-D (maleate),SCH-417690 (maleate) |
HIV Protease; CCR | Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome |
Vicriviroc maleate (SCH-417690 (maleate)) 是一种可口服,可透过血脑屏障的 CCR5选择性拮抗剂,同时抑制外周血单核细胞中的 HIV-1 的活性。 | |||
T2375 |
BX471
BX 471,BX-471,ZK-811752 |
CCR | Immunology/Inflammation; Microbiology/Virology |
BX471 (BX 471) 是可口服的非多肽 CCR1选择性拮抗剂,Ki 值为 1 nM,对其选择性是对 CCR2、CCR5 和 CXCR4 的 250 倍。 | |||
T28171 |
Nifeviroc
TD-0232,TD 0232,尼非韦罗,TD0232 |
Others | Others |
Nifeviroc, a CCR5 antagonist, is used potentially for treatment of inflammatory responses to HIV type-1 infection. | |||
T10756 |
Cenicriviroc Mesylate
TBR-652 Mesylate,TAK-652 Mesylate |
CCR | Immunology/Inflammation; Microbiology/Virology |
Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity. | |||
T23770 |
B07 hydrochloride
B 07 HCl,B-07 HCl,B-07 hydrochloride,B07 HCl,B 07 hydrochloride |
Others | Others |
B07 hydrochloride is a CCR5 antagonist-based inhibitor of HIV-1 entry. | |||
T28381 |
PF-232798
PF-00232798,PF 00232798,PF00232798 |
Others | Others |
PF-232798 is a second generation oral CCR5 antagonist with potent broad-spectrum anti-HIV-1 activity. | |||
T14845 |
BX471 hydrochloride
ZK-811752 hydrochloride |
Others | Others |
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |||
T76567 |
Met-RANTES (human)
|
||
Met-RANTES (human) 为一部分CCR5拮抗剂,能够降低血液单核细胞向肝脏浸润的程度。 | |||
T69582 |
AMD-3451 free base
|
Others | Others |
AMD-3451 free base is a dual CCR5/CXCR4 antagonist which may be useful in the treatment of a wide variety of R5, R5/X4, and X4 strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2. AMD3451 is the first low-molecular-weight anti-HIV agent with selective HIV coreceptor, CCR5 and CXCR4, interaction. | |||
T14208 |
AMD 3465
GENZ-644494 |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC |