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Search Results for " ccl5 "

Targets Recommended: GPR Potassium Channel

8

抑制剂 & 化合物

1

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1781	GW9508 GW 9508	GPR; Potassium Channel	Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel
	GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂，具有抗炎和抗动脉粥样硬化活性。
T78011	Cyclic MKEY TFA
	Cyclic MKEY TFA为CXCL4-CCL5异二聚体的合成环肽抑制剂，可通过调控炎症反应预防动脉粥样硬化和主动脉瘤。此外，该化合物亦能阻止小鼠中风后脑损伤的发生。
TP1620	Cyclic MKEY
	MKEY, a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, has been shown to protect against atherosclerosis and aortic aneurysm formation by mediating inflammation, but whether it modulates neuroinflammation and brain injury has not
T80470	Citrullinated LL-37 2cit
	Citrullinated LL-37 2cit是瓜氨酸化的LL-37肽，在10 μg/mL浓度下可减弱LL-37对HRV活性的抑制，并降低LL-37的抗菌效果。此外，Citrullinated LL-37 2cit能显著降低RV1B诱导的IL-8、CCL5和IL-6 mRNA水平，并对HRV诱导的CCL5分泌能力有中度抑制作用。
T61621	IMMH001
	IMMH001, also known as SYL930, is an orally active compound that exhibits potent selectivity as an agonist for the S1P1 receptor, which is the sphingosine-1-phosphate receptor 1. This compound effectively reduces the levels of various chemokines and proinflammatory cytokines, such as IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 finds utility in research focused on rheumatoid arthritis (RA) [1] [2].
T80469	Citrullinated LL-37 1cit
	Citrullinated LL-37 1cit 是一种Citrullinated形式的 LL-37 肽，保持了针对 human rhinovirus 的抗病毒 (antiviral) 功能，同时对S. aureus 表现出抗菌 (antibacterial) 活性。此外，Citrullinated LL-37 1cit 能够降低 RV1B 诱导的 IL-8、CCL5 和 IL-6mRNA 水平。
T80474	Citrullinated LL-37 4cit
	Citrullinated LL-37 3cit是一种经过瓜氨酸化处理的LL-37肽。在10 μg/mL浓度下，该化合物未表现出抗病毒活性；而在30 μg/mL时，对HRV保持一定程度的活性。相较于未修饰的LL-37，Citrullinated LL-37 3cit的免疫调节活性有所下降。此外，Citrullinated LL-37 3cit在减缓HRV诱导的CCL5分泌方面呈现中度损失。
T73516	EVT801
	EVT801 是一种口服有效、选择性的 VEGFR-3抑制剂 (IC50=11 nM)，具有抗肿瘤作用。EVT801 不仅抑制VEGF-C 诱导的人内皮细胞增殖，还抑制肿瘤小鼠模型中的肿瘤 (淋巴) 血管生成。EVT801 能够减少肿瘤缺氧，减少免疫抑制细胞因子 (CCL4、CCL5) 和髓系衍生抑制细胞 (MDSC) 产生。EVT801 与免疫检查点疗法 (ICT) 组有协同作用，它提高 ICT 应答率，对癌小鼠模型的抑制效果更好。

化合物

Cat.No: T1781

Synonym: GW 9508

Target: GPR, Potassium Channel

Cyclic MKEY TFA

Cat.No: T78011

Cat.No: TP1620

Citrullinated LL-37 2cit

Cat.No: T80470

Cat.No: T61621

Citrullinated LL-37 1cit

Cat.No: T80469

Citrullinated LL-37 4cit

Cat.No: T80474

Cat.No: T73516

Cat. No.	Product Name	Target	Signaling Pathways
T4115	Auraptene 橙皮油内酯,7-geranyloxycoumarin,橙皮油素	MMP; BACE	Neuroscience; Proteases/Proteasome
	Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。

天然产物

Cat.No: T4115

Synonym: 橙皮油内酯,7-geranyloxycoumarin,橙皮油素

Target: MMP, BACE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-00008	CCL5 Protein, Mouse, Recombinant (hFc) D17S136E,RANTES,SCYA5,SIS-δ,Ccl5,...	Mouse	HEK293 Cells
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with N-hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is P30882.
TMPK-00009	CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated RANTES,SIS-δ,D17S136E,TCP228,eoCP,SIS-delta,SCYA5,<...	Human	E. coli
	The CCR5 and the CCL5 ligand have been detected in some hematological malignancies, lymphomas, and a great number of solid tumors, but extensive studies on the role of the CCL5/CCR axis were performed only in a limited number of cancers. CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-His-Avi tag. The predicted molecular weight is 10.89 kDa and the accession number is P13501.
TMPJ-00993	CCL5 Protein, Rat, Recombinant (E. coli, His) Small-inducible cytokine A5,SIS-δ,C-C motif chemoki...	Rat	E. coli
	C-C motif chemokine 5(CCL5) is a β-chemokine that plays a primary role in the inflammatory immune response by means of its ability to attract and activate leukocytes. CCL5 is secreted by many cell types at inflammatory sites, and it exerts a wide range of activities through the receptors CCR1, CCR3, CCR4, and CCR5. Inflammatory responses can be impaired by the sequestration of CCL5 by the cytomegalovirus protein US28. Oligomerization of CCL5 on glycosaminoglycans is required for CCR1mediated leu...
TMPY-04214	CCL5 Protein, Human, Recombinant SISd,TCP228,chemokine (C-C motif) ligand 5,RANTES,S...	Human	E. coli
	CCL5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 8 kDa and the accession number is D0EI67.
TMPY-04917	CCL5 Protein, Rat, Recombinant (His) chemokine (C-C motif) ligand 5	Rat	P. pastoris (Yeast)
	CCL5 Protein, Rat, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.2 kDa and the accession number is P30882.
TMPY-01072	CCL5 Protein, Human, Recombinant (His & mucin) D17S136E,SCYA5,SIS-δ,SISd,SIS-delta,RANTES,chemokin...	Human	HEK293 Cells
	CCL5 Protein, Human, Recombinant (His & mucin) is expressed in HEK293 mammalian cells with His and mucin tag. The predicted molecular weight is 34 kDa and the accession number is D0EI67.
TMPH-02738	IRAK3 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus Insect Cells
	Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors. Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex. Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells. IRAK3 Protein, Mouse, Recombinant (His & Myc) is expressed in ...

重组蛋白

CCL5 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00008

Species: Mouse

Expression System: HEK293 Cells

CCL5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00009

Species: Human

Expression System: E. coli

CCL5 Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPJ-00993

Species: Rat

Expression System: E. coli

CCL5 Protein, Human, Recombinant

Cat.No: TMPY-04214

Species: Human

Expression System: E. coli

CCL5 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04917

Species: Rat

Expression System: P. pastoris (Yeast)

CCL5 Protein, Human, Recombinant (His & mucin)

Cat.No: TMPY-01072

Species: Human

Expression System: HEK293 Cells

IRAK3 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02738

Species: Mouse

Expression System: Baculovirus Insect Cells

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