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Search Results for " bradycardia "

14

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8441	Lerisetron	5-HT Receptor	GPCR/G Protein; Neuroscience
	Lerisetron 是5-HT3拮抗剂，与 5-HT3受体具有高亲和力(pKi:9.2)。它对尿烷麻醉大鼠的 5-HT 引发的反射性心率过缓具有抑制作用。
T7421	Melperone	Others	Others
	Melperone 是一种丁酰苯，是一种具有睡眠诱导作用的抗精神病试剂，常用于研究精神类疾病。
T13370	YM-46303	AChR	Neuroscience
	YM-46303 是一种具有选择性和有效性的毒蕈碱受体拮抗剂，对 M3 受体表现出较高的亲和力。YM-46303 可用于研究髓状大鼠心动过缓。
TP1898	HS024 HS 024	Melanocortin Receptor	GPCR/G Protein; Neuroscience
	HS024 是一种选择性的MC4受体拮抗剂，可增加食物摄入，对 MC4、MC5、MC3 和 MC1 的Ki 分别为 0.29、3.29、5.45 和 18.6 nM。
T70729	Indisetron
	Indisetron is a 5-HT(3) and 5-HT(4) receptor antagonist. Indisetron reduces 2-methyl-5-serotonin (HT)-induced bradycardia.
T21411	Isoproterenol Norisodrine,Isoprenaline,Novodrin,Isuprel,Medihaler-Iso	Endogenous Metabolite; Adrenergic Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Isoproterenol (Norisodrine) 是一种非选择性且具有口服活性的 β-肾上腺素受体激动剂。Isoproterenol 是有效的外周血管扩张剂和支气管扩张剂。Isoproterenol 可用于研究心动过缓和支气管哮喘，用于治疗心脏传导阻滞、心动过缓。
T31119	CVT-2759 UNII-42E8N8RC9Z,CVT2759
	CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias, or vasodilation.
T68263	MDL-72567
	MDL-72567 is a dihydropyridine calcium antagonist that causes vasodilation and direct sinus bradycardia.
T27607	Indisetron Dihydrochloride N3389T,Sinseron,N-3389T,N 3389T
	Indisetron Dihydrochloride is a 5-HT(3) and 5-HT(4) receptor antagonist. Indisetron reduces 2-methyl-5-serotonin (HT)-induced bradycardia.
T38443	Methoctramine tetrahydrochloride
	Methoctramine tetrahydrochloride is a potent and cardioselective antagonist of the M2 muscarinic receptor, capable of inhibiting Muscarine-induced bradycardia in vivo.
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moiety linked to an adenosine A1 receptor (A1AR) allosteric modulator moiety. At the A1AR, VCP746 mediated cardioprotection in the absence of haemodynamic side effects such as bradycardia.
T26770	Bencycloquidium Bromide BCQB
	Bencycloquidium Bromide is a muscarinic M3 antagonist. Bencycloquidium bromide inhibits nasal hypersecretion in a rat model of allergic rhinitis. Bencycloquidium Bromide showed high affinity toward the M(3) receptor in Chinese hamster ovary (CHO) cells (M
T37728	Methoctramine (hydrate)
	Methoctramine is a selective antagonist of M2 muscarinic acetylcholine receptors (IC50 = 6.1 nM in CHO-K1 cell membranes).[1] It is selective for M2 over M1, M3, M4, and M5 receptors (IC50s = 92, 770, 260, and 217 nM, respectively). In vitro, methoctramine inhibits acetylcholine-induced reductions in isolated guinea pig tracheal tube contractions when used at a concentration of 1 μM.[2] In vivo, methoctramine inhibits bradycardia and bronchoconstriction induced by acetylcholinein guinea pigs wit...
T31194	Dalapon Basfapon B,Dowpon M,Dawpon-Rae
	Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the

化合物

Cat.No: T8441

Target: 5-HT Receptor

Cat.No: T7421

Target: Others

Cat.No: T13370

Target: AChR

Cat.No: TP1898

Synonym: HS 024

Target: Melanocortin Receptor

Cat.No: T70729

Cat.No: T21411

Synonym: Norisodrine,Isoprenaline,Novodrin,Isuprel,Medihaler-Iso

Target: Endogenous Metabolite, Adrenergic Receptor

Cat.No: T31119

Synonym: UNII-42E8N8RC9Z,CVT2759

Cat.No: T68263

Indisetron Dihydrochloride

Cat.No: T27607

Synonym: N3389T,Sinseron,N-3389T,N 3389T

Methoctramine tetrahydrochloride

Cat.No: T38443

Cat.No: T70421

Bencycloquidium Bromide

Cat.No: T26770

Synonym: BCQB

Methoctramine (hydrate)

Cat.No: T37728

Cat.No: T31194

Synonym: Basfapon B,Dowpon M,Dawpon-Rae

Cat. No.	Product Name	Target	Signaling Pathways
T10913	Cyclobuxine D	Others	Others
	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclostatin D has obvious bradycardia effect on rat heart, and inhibits acetylcholine and Ba ++ induced longitudinal muscle contraction isolated from rabbit jejunum.
T2S1727	Lycorenine	Antifection	Microbiology/Virology
	Lycorenine may produce a decrease in blood pressure as the result of alpha-adrenergic blockade in conjunction with the reduction of the spontaneous sympathetic nerve activity, and produce bradycardia by modifying vagal activity. The development of tachyph

天然产物

Cat.No: T10913

Target: Others

Cat.No: T2S1727

Target: Antifection

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