首页工具

登录

搜索结果

Search Results for " bcr-abl-in-1 "

15

抑制剂 & 化合物

1

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T10488	BCR-ABL-IN-1	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-1 is a BCR-ABL tyrosine kinase inhibitor (pIC50: 6.46) and may be used in the research of chronic myelogenous leukemia.
T11916	Lyn-IN-1 巴非替尼,Bafetinib analog	Bcr-Abl; Src	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Lyn-IN-1 (Bafetinib analog) 是一种高活性 Bcr-Abl 和 Lyn 双重抑制剂。
T64338	AKI603 AKI 603,AKI-603	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	AKI603 是一种极光激酶 A 抑制剂，IC50值为 12.3 nM。它对白血病细胞具有很强的抗增殖活性，可用于克服白血病中 BCR-ABL-T315I 耐药性突变。
T21785	AG957	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Tyrphostin AG957 是一种酪氨酸激酶抑制剂，具有抗BCR/ABL 酪氨酸激酶活性。它能够抑制p210bcr/abl 酶活性 (IC50:2.9 μM)。
T37600	Dasatinib N-oxide	Others	Others
	Dasatinib N-oxide 是 Dasatinib 的一种次要代谢物。Dasatinib 是口服有效的 Src/Bcr-Abl 抑制剂。
T82909	BCR-ABL-IN-8	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	BCR-ABL-IN-8（化合物26f）是一种具有三甲氧基基团（trimethoxy group）的BCR-ABL抑制剂。
T11977	Mcl1-IN-9	BCL	Apoptosis
	Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM.
T77969	SIAIS100 TFA	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	SIAIS100 TFA是一款高效的BCR-ABL PROTAC降解剂，其DC50值为2.7 nM，主要应用于慢性粒细胞白血病（CML）的研究。
T77974	PROTAC BCR-ABL Degrader-1	PROTACs	PROTAC
	PROTACBCR-ABLDegrader-1（化合物PROTAC1）是一种含有2-oxoethyl linker的PROTAC。该化合物能通过泛素蛋白酶体（ubiquitinproteasom）系统诱导Bcr-Abl的降解，并对K562细胞表现出抗增殖效果，显示出其在癌症研究中的应用潜力。
T71313	BVB-808
	BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning int...
T61324	BCR-ABL1-IN-1
	BCR-ABL1-IN-1 is a highly potent and orally bioavailable inhibitor, displaying remarkable specificity towards ABL kinase. Notably, this compound holds significant promise for delineating the precise involvement of ABL kinases within the central nervous system, particularly in preclinical investigations [1].
T18694	SNIPER(ABL)-050	Others	Others
	SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].
T75012	SIAIS100
	SIAIS100 是一种有效的BCR-ABLPROTAC 降解剂，DC50为 2.7 nM。SIAIS100 可用于研究慢性粒细胞白血病 (CML)。
T73973	Imatinib Impurity E
	Imatinib Impurity E 是 Imatinib 的杂质。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。Imatinib (STI571) 靠近 ATP 结合位点结合，将其锁定在封闭或自我抑制的构象中，因此半竞争性抑制蛋白质的酶活性。Imatinib 还抑制 SARS-CoV 和MERS-CoV。
T36578	Boc-Lys(Ac)-AMC
	Commendamide (N-acyl-3-hydroxypalmitoyl-glycine) is a newly discovered GPCR G2A/GPR132 agonist (EC50=11.8 μM) that isolated from Bacteroides vulgatus. [1] G2A/GPR132 belongs to the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. GPR132/G2A is first reported to be a transcriptional target for BCR-ABL tyrosine kinase attenuating B-cell expansion in vitro and arresting cells at G2 during mitosis. It has been involved in autoimmune disease and atherosclerosis. [1]...

化合物

BCR-ABL-IN-1

Cat.No: T10488

Target: Bcr-Abl

Cat.No: T11916

Synonym: 巴非替尼,Bafetinib analog

Target: Bcr-Abl, Src

Cat.No: T64338

Synonym: AKI 603,AKI-603

Target: Aurora Kinase

Cat.No: T21785

Target: Bcr-Abl

Dasatinib N-oxide

Cat.No: T37600

Target: Others

BCR-ABL-IN-8

Cat.No: T82909

Target: Bcr-Abl

Cat.No: T11977

Target: BCL

Cat.No: T77969

Target: Bcr-Abl

PROTAC BCR-ABL Degrader-1

Cat.No: T77974

Target: PROTACs

Cat.No: T71313

BCR-ABL1-IN-1

Cat.No: T61324

SNIPER(ABL)-050

Cat.No: T18694

Target: Others

Cat.No: T75012

Imatinib Impurity E

Cat.No: T73973

Boc-Lys(Ac)-AMC

Cat.No: T36578

Cat. No.	Product Name	Target	Signaling Pathways
T3S1553	trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein	COX; Endogenous Metabolite	Immunology/Inflammation; Metabolism; Neuroscience
	trans-Cinnamaldehyde (Phenylacrolein) 是一种能够用于合成反式肉桂醛-β-环糊精复合物，一种能够食用的抗菌涂层，能够延长鲜切水果的保质期。它是一种能够通过烷基异氰化物与乙炔二羧酸二烷基酯的反应来合成高度多官能的呋喃环。

天然产物

trans-Cinnamaldehyde

Cat.No: T3S1553

Synonym: Cinnamaldehyde,Cinnamic aldehyde,桂皮醛,反式肉桂醛,Cinnamal,Phenylacrolein

Target: COX, Endogenous Metabolite

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼