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Search Results for " bclxl "

Targets Recommended: BCL

4

抑制剂 & 化合物

1

天然产物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T38622	Bcl-xL antagonist 2	BCL	Apoptosis
	Bcl-xL antagonist 2 是一种有效的选择性 Bcl-xL 拮抗剂，IC50 为 91 nM，Ki 为 65 nM。 Bcl-xL antagonist 2 可诱导癌细胞凋亡，可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。
T14376	AZD4320	BCL	Apoptosis
	AZD4320 是一种BCL2/BCLxL 双重抑制剂，是 BH-3 类似物，对 KPUM-MS3、KPUM-UH1 和 STR-428 细胞，IC50 值分别为 26 nM、17 nM 和 170 nM。
T70008	Bomedemstat ditosylate
	Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndrome, and Myelofibrosis. IMG-7289 selectively inhibited proliferation and induced apoptosis of JAK2 V617F cells by concomitantly increasing expression and methylation of p53, and, independently, the pro-apoptotic factor PUMA and by decreasing the levels of its antiapoptotic antago...
T29172	YD277 YD 277,YD-277
	YD277 is a small molecule derived from ML264, a KLF5 inhibitor that elicits cytotoxic effects in colon cancer cell lines. YD277 significantly induced G1 cell cycle arrest and apoptosis in MDA-MB-231 and MDA-MB-468 TNBC cells, independent of KLF5 inhibitio

化合物

Bcl-xL antagonist 2

Cat.No: T38622

Target: BCL

Cat.No: T14376

Target: BCL

Bomedemstat ditosylate

Cat.No: T70008

Cat.No: T29172

Synonym: YD 277,YD-277

Cat. No.	Product Name	Target	Signaling Pathways
T6S0052	Chelerythrine Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine	Apoptosis; BCL; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。

天然产物

Cat.No: T6S0052

Synonym: Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02431	BCL-XL Protein, Human, Recombinant (His) bcl-xS,PPP1R52,Bcl-X,BCLXL,BCLX,BCLXS,BCL2-like 1,b...	Human	E. coli
	BCL-XL Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.2 kDa and the accession number is A0A0S2Z3C5.
TMPH-02650	FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.

重组蛋白

BCL-XL Protein, Human, Recombinant (His)

Cat.No: TMPY-02431

Species: Human

Expression System: E. coli

FCMR/FAIM3 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02650

Species: Mouse

Expression System: E. coli

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