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Search Results for " as2 "

Targets Recommended: Others

11

抑制剂 & 化合物

6

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10381	AS2717638	Others	Others
	AS2717638 是一种具有口服生物活性的，选择性的溶血磷脂酸受体5 (LPA5) 的拮抗剂，其对 hLPA4 的 IC50值为38 nM。AS2717638 还能显著改善 PGE2、PGF2α以及 AMPA 诱导的异位疼痛。
T4359	VAS2870	NADPH	Metabolism
	VAS2870 是一种NADPH 氧化酶抑制剂。
T8378	AS2863619	CDK; STAT	Cell Cycle/Checkpoint; JAK/STAT signaling; Stem Cells
	AS2863619 是一种口服的细胞周期蛋白依赖性激酶 8 和CDK19抑制剂，抑制CDK8/19可增强STAT5的激活，从而激活 Foxp3 基因。它可将抗原特异性效应子/记忆 T 细胞转换为 Foxp3+调节性 T 细胞，以研究各种免疫疾病。
T14328	AS2521780	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
T81039	TAS2R14 agonist-2
	TAS2R14 agonist-2 (compound 28.1) 作为选择性TAS2R14抑制剂，其EC50为72 nM。
T81040	TAS2R14 agonist-1
	TAS2R14 agonist为一种TAS2R14受体的部分激活分子，其EC50值确定为116.6±23.6 nM。
T70345	JAS239
	JAS239 is a novel carbocyanine dye that binds and competitively inhibits choline kinase (ChoK) intracellularly. JAS239 attenuated choline phosphorylation and viability in a panel of human breast cancer cell lines. Antibody blockade prevented cellular retention of JAS239 indicating direct interaction with ChoKα independent of the choline transporters and catabolic choline pathways. In mice bearing orthotopic MCF7 breast xenografts, optical imaging with JAS239 distinguished tumors overexpressing C...
T70373	AS2575959
	AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion.
T26664	AS2553627 AS 2553627,AS-2553627
	AS2553627 is a JAK inhibitor. AS2553627 prevents chronic rejection in rat cardiac allografts.
T69912	AS2541019
	AS2541019 is a selective Phosphatidylinositol-3-kinase p110δ (PI3Kδ) inhibitor.
T10382	AS2863619 free base	CDK	Cell Cycle/Checkpoint
	AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 activation enhanced by AS2863619 free base inhibition of CDK8/19, which consequently activates the Foxp3 gene.

化合物

Cat.No: T10381

Target: Others

Cat.No: T4359

Target: NADPH

Cat.No: T8378

Target: CDK, STAT

Cat.No: T14328

Target: PKC

TAS2R14 agonist-2

Cat.No: T81039

TAS2R14 agonist-1

Cat.No: T81040

Cat.No: T70345

Cat.No: T70373

Cat.No: T26664

Synonym: AS 2553627,AS-2553627

Cat.No: T69912

AS2863619 free base

Cat.No: T10382

Target: CDK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00670	ARSA Protein, Mouse, Recombinant (His) arylsulfatase A,TISP73,AW212749,<...	Mouse	HEK293 Cells
	ARSA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 53.5 kDa and the accession number is P50428.
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) ATX II,Delta-AITX-Avd1c,Toxin II,Delta-actitoxin-Avd1c,Neuro...	Anemonia sulcata	P. pastoris (Yeast)
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured...
TMPH-02005	RRAS2 Protein, Human, Recombinant (GST)	Human	E. coli
	RRAS2 Protein, Human, Recombinant (GST) is expressed in E. coli.
TMPH-02336	TAS2R10 Protein, Human, Recombinant (His & KSI)	Human	E. coli
	Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. TAS2R10 Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.6 kDa and the accession number is Q9NYW0.
TMPJ-00705	BCAS2 Protein, Human, Recombinant (His, T7) BCAS2,DNA Amplified in Mammary Carcinoma 1...	Human	E. coli
	Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator ...
TMPH-02715	HAS2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	HAS2 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.9 kDa and the accession number is P70312.

重组蛋白

ARSA Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00670

Species: Mouse

Expression System: HEK293 Cells

Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Cat.No: TMPH-00056

Species: Anemonia sulcata

Expression System: P. pastoris (Yeast)

RRAS2 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02005

Species: Human

Expression System: E. coli

TAS2R10 Protein, Human, Recombinant (His & KSI)

Cat.No: TMPH-02336

Species: Human

Expression System: E. coli

BCAS2 Protein, Human, Recombinant (His, T7)

Cat.No: TMPJ-00705

Species: Human

Expression System: E. coli

HAS2 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02715

Species: Mouse

Expression System: E. coli

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