6
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T31931L |
Gizzerosine HCl
Gizzerosine HCl(89238-78-8 Free base) |
Others | Others |
Gizzerosine 2HCl是鱼粉热处理过程中产生的一种物质,可诱导的肉鸡雏鸡组织病理学病变,可提高离体鸡原产鸡的细胞内环腺苷-3',5'-单磷酸水平。 | |||
T1024 |
Roflumilast
罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217 |
PDE; RSV | Metabolism; Microbiology/Virology |
Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。 | |||
T1139 |
Salbutamol
Albuterol,沙丁胺醇,AH-3365 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。 | |||
T25463 |
Griseolic acid
|
||
Griseolic acid is a cyclic adenosine 3',5'-monophosphate phosphodiesterase II inhibitor. | |||
T32156 |
Indimilast
|
||
Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst | |||
T63776 |
PDE1-IN-4
|
||
PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂,能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷),表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
TN1841 |
Kushenol A
苦参新醇 A,Leachianone E |
cAMP | GPCR/G Protein |
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). | |||
TN4433 |
Licoarylcoumarin
|
cAMP; HIV Protease; Antifection | GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase. |