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Cat. No. | Product Name | Target | Signaling Pathways |
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T35571 | Adenosine 3’-monophosphate (sodium salt hydrate) | ||
Adenosine 3’-monophosphate is a nucleotide and metabolite formedviahydrolysis of 2’,3’-cAMP by metal-dependent phosphodiesterases.1It reduces proliferation of rat preglomerular vascular smooth muscles cells (PGVSMCs) and glomerular mesangial cells (GMCs) in a concentration-dependent manner, an effect that is abolished by the adenosine A2Breceptor antagonist MRS1754.2Adenosine 3’-monophosphate is also a metabolic intermediate in the biosynthesis of adenosine . | |||
T31931L |
Gizzerosine HCl
Gizzerosine HCl(89238-78-8 Free base) |
Others | Others |
Gizzerosine 2HCl是鱼粉热处理过程中产生的一种物质,可诱导的肉鸡雏鸡组织病理学病变,可提高离体鸡原产鸡的细胞内环腺苷-3',5'-单磷酸水平。 | |||
T1024 |
Roflumilast
罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217 |
PDE; RSV | Metabolism; Microbiology/Virology |
Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4),具有抗炎和潜在的抗肿瘤活性,作用于PDE4A1,PDEA4,PDEB1和PDEB2,IC50分别为 0.7,0.9,0.7 和 0.2 nM。 | |||
T1139 |
Salbutamol
Albuterol,沙丁胺醇,AH-3365 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Salbutamol (Albuterol) 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病(COPD) 引发的支气管痉挛的研究。 | |||
T25463 |
Griseolic acid
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Griseolic acid is a cyclic adenosine 3',5'-monophosphate phosphodiesterase II inhibitor. | |||
T32156 |
Indimilast
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Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst | |||
T63776 |
PDE1-IN-4
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PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂,能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷),表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。 | |||
T35573 |
Adenosine 5’-methylenediphosphate (hydrate)
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Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ... | |||
TMIH-0512 |
Salbutamol-d3
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Salbutamol-d3 是 Salbutamol 的氘代化合物。Salbutamol 的 CAS 号为 18559-94-9。Salbutamol 是短效的 β2 肾上腺素受体激动剂,用于哮喘和慢性阻塞性肺疾病 (COPD) 引发的支气管痉挛的研究。 | |||
T65598 | Cefminox sodium | ||
Cefminox (Sodium) is a new cephamycin antibiotic possessing a D-amino acid moiety derived from D-cysteine at the C-7B side chain. Cefminox is active against a wide range of bacteria, especially Gram-negative and anaerobic bacteria. Cefminox shows excellent in vivo efficacy (ED50) which is higher than would be expected from its in vitro activity (MIC). Moreover, cefminox possesses more potent activity in suppression of bacterial regrowth than other cephems[1]. Cefminox (Sodium) was the most activ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TCO2745 |
Cyclic AMP
Adenosine 3',5'-cyclophosphate,cAMP,腺苷环磷酸酯,环磷腺苷,Cyclic 3',5'-monophosphate adenosine,3',5'-AMP,Adenosine Cyclophosphate |
Others; Endogenous Metabolite | Metabolism; Others |
Cyclic AMP (cAMP)(Adenosine 3',5'-cyclophosphate) 是有丝分裂信使,可以促进 G1期到 S 期的细胞周期进程。 | |||
TN1841 |
Kushenol A
苦参新醇 A,Leachianone E |
cAMP | GPCR/G Protein |
Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2). | |||
TN4433 |
Licoarylcoumarin
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cAMP; HIV Protease; Antifection | GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome |
Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase. |