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Cat. No. Product Name Target Signaling Pathways
T1920 Capivasertib

AZD5363

Akt; PKA; mTOR; Autophagy Autophagy; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
Capivasertib (AZD5363) 是一种广谱的 AKT 抑制剂,对 Akt1、Akt2 和 Akt3 均有抑制活性 (IC50=3/7/7 nM),具有口服活性。Capivasertib 具有抗肿瘤活性,可以用于治疗乳腺癌。
T71242 AZD-1897

AZD-1897 is an ATP-competitive pan-PIM inhibitor. When combined with the Akt inhibitor AZD5363, AML cells from putative leukaemia stem cells incur a reduction in levels of the anti-apoptotic protein MCL1. The combination of PIM and Akt inhibition holds promise for the treatment of AML.

化合物

Capivasertib
Cat.No: T1920
Synonym: AZD5363
Target: Akt, PKA, mTOR, Autophagy
AZD-1897
Cat.No: T71242
Synonym:
Target:
TargetMol Loading
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