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抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T75279	Tigecycline tetramesylate
	Tigecycline tetramesylate (GAR-936 tetramesylate)为一款广谱甘氨酰环素类抗生素，对E. coli (MG1655菌株)展现出约125 ng/mL的平均抑制浓度(MIC)。针对Acinetobacter baumannii (A. baumannii)的MIC50与MIC90分别达到1 mg/L与2 mg/L。
T36025	Deoxyviolacein
	Deoxyviolacein is a bacterial metabolite and byproduct in the biosynthesis of the bisindole alkaloid violacein that has anticancer, antibacterial, and antifungal properties. It inhibits proliferation of hepatocellular carcinoma cells when used at concentrations ranging from 0.1 to 1 μM. Deoxyviolacein (125 μg/ml) has antibacterial activity against Gram-positive bacteria, including S. aureus, B. subtilis, and B. megaterium. It also has antifungal activity against R. solani when used at a concentr...
T36577	K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt) K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)
	Histone H2B (108-125) is a peptide fragment of histone H2B that corresponds to amino acid residues 109-126 of the human histone H2B sequence. It contains an N-terminal biotinylated lysine followed by a tryptophan linker. Histone H2B can be modified by addition of an O-linked N-acetylglucosamine (GlcNAc) moiety to the serine residue at position 112, which promotes monoubiquitination of the lysine at position 120.1 Both of these modifications are associated with active transcription. Histone H2B a...
T38145	Eltoprazine
	Eltoprazine(DU28853) is a serenic or antiaggressive agent which as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor.IC50 value:Target: 5-HT1A/1B agonist; 5-HT2C antagonistin vitro: The binding of [3H]eltoprazine to whole tissue sections was saturable and revealed an apparent dissociation constant (Kd) of 11 nM. Specific [3H]eltoprazine binding was completely displaced by 5-HT; conversely, unlabelled eltoprazine reduced [3H]5-HT binding to the levels of no...
T35791	Palmitic acid-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid-13C contains 13C at the C2 position and has been used in the study of free fatty acid incorporation into phospholipid fatty acids in soil microbes.1 Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.2 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.3 Palmitic ...
T35789	Palmitic acid-1-13C
	Palmitic acid-13C is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a 16-carbon saturated fatty acid. It comprises approximately 25% of human total plasma lipids.1 It increases protein levels of COX-2 in RAW 264.7 cells when used at a concentration of 75 μM.2 Palmitic acid is involved in the acylation of proteins to anchor membrane-bound proteins to the lipid bilayer.2,3,4,5,6 \|1. Santos, M.J., López-Jurado, M., Llopis, J., et a...
T35854	9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)
	9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid that has been found in beef and milk fat.1It binds to peroxisome proliferator-activated receptor α (PPARα; IC50= 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 μM.29(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-inducedGLUT4expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3Dietary administration of 9(Z)11(E)-co...

化合物

Tigecycline tetramesylate

K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

Cat.No: T36577

Synonym: K-Biotin-W-Histone H2B (108-125) (trifluoroacetate salt)

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt)

Cat.No: T35854

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T14114	Acivicin 阿西维辛,AT-125,U-42126	Others	Others
	Acivicin (AT-125) is a γ-glutamyl transpeptidase (GGT) inhibitor derived from the Streptomyces sviceus natural product. It possesses anti-cancer and anti-parasitic properties and can effectively cross the blood-brain barrier[1][2].
T77207	Acivicin hydrochloride
	Acivicin hydrochloride (AT-125 hydrochloride)，一种猪链霉菌的天然产物，兼具透过血脑屏障的能力，是γ-谷氨酰转肽酶 (GGT) 的抑制剂，具有抗癌和抗寄生虫的特性。
TN3397	Alpinumisoflavone	ERK; LDL; NF-κB; MEK; MAPK; Antifection	MAPK; Metabolism; Microbiology/Virology; NF-κB
	Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is endowed with estrogenic properties accounting, at least in part, for E. lysistemon effects. Alp