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Search Results for " apx "

Targets Recommended: NADPH-oxidase

10

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10354	APX-115 Ewha-18278	NADPH-oxidase	Immunology/Inflammation
	APX-115 (Ewha-18278) (Ewha-18278) 是一种有效的，口服活性的，非选择性 Nox 抑制剂，对 Nox1，Nox2 和 Nox4 的 Ki 值分别为 1.08 μM，0.57 μM 和 0.63 μM。APX-115 可有效预防糖尿病小鼠的肾损伤。
T61355	APX2039 APX-2039,APX 2039	Antifungal	Microbiology/Virology
	APX2039 是一种口服有效的真菌 Gwt1 酶 (fungal Gwt1 enzyme) 抑制剂，是新型Gwt2096抑制剂APX1的前药。APX2039 对 C. neoformans 和 C. gattii 展现出极强的抗氪球菌活性。APX2039 具有有效的抗真菌活性，科阻断 GPI (糖基磷脂酰肌醇)锚定细胞壁甘露蛋白的定位。APX2039 可用于研究隐球菌脑膜炎 (CM) 。
T10353	APX-115 free base Ewha-18278 free base	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。
T23749	APX001 APX 001,APX-001
	APX001 is a prodrug of APX-001A. APX001 is the first-in-class inhibitor of the fungal protein Gwt1.
T70732	APX2014
	APX2014 is a novel potent and specific Ref-1 inhibitor, blocking in vitro cell proliferation and activating apoptosis via PARP cleavage.
T70733	APX2009
	APX2009 is a second-generation APE1/Ref-1 redox-specific inhibitor. APX2009 significantly reduces NFkB transcriptional activity, survivin mRNA, and survivin protein levels. APX2009 decreases prostate cancer cell proliferation and induces cell cycle arrest.
T70731	Odalasvir
	Odalasvir is a novel NS5A inhibitor for the treatment of hepatitis C.
T6823	E3330	HIF/HIF Prolyl-Hydroxylase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	E3330 是一种口服有效的选择性 AP 内切核酸酶 1 (APE1; REF-1) 抑制剂，可抑制NF-κB DNA 结合活性。它阻断 TNF-α 诱导的肝癌细胞系中 IL-8 的激活，可以抑制癌细胞的生长和迁移，具有抗癌活性。
T70730	Oxycodegol phosphate
	Oxycodegol phosphate is a mu-opioid agonist used in the treatment of Moderate to Severe Chronic Low Back Pain
T11314	Fosmanogepix APX001,E1211	Others	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.

化合物

Cat.No: T10354

Synonym: Ewha-18278

Target: NADPH-oxidase

Cat.No: T61355

Synonym: APX-2039,APX 2039

Target: Antifungal

APX-115 free base

Cat.No: T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Cat.No: T23749

Synonym: APX 001,APX-001

Cat.No: T70732

Cat.No: T70733

Cat.No: T70731

Cat.No: T6823

Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis

Oxycodegol phosphate

Cat.No: T70730

Cat.No: T11314

Synonym: APX001,E1211

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02433	APE1/APEX1 Protein, Human, Recombinant (His) APEX,HAP1,APX,APE,APEX nuclease (multifunctional DN...	Human	E. coli
	The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diesterase, 3'-5' exonuclease and DNA 3'-phosphatase activities.Although Apex mRNA was expressed ubiquitously, the levels varied significantly, suggesting organ- or tissue-specific expression of the Apex gene. The highest level was observed in the testis, relatively high levels in the...
TMPJ-00464	APE Protein, Human, Recombinant APEX,Apurinic-Apyrimidinic Endonuclease 1,APEN,DNA-(Apurinic...	Human	E. coli
	Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases, APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors, which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors, such as c-Jun, c-Fos, NF-kB, p53. APEN is also involved in calcium-dependent down...
TMPH-00096	APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His) APX1b,APX2,L-ascorbate peroxidase 2, cytos...	Arabidopsis thaliana	E. coli
	APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is Q1PER6.

重组蛋白

APE1/APEX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02433

Species: Human

Expression System: E. coli

APE Protein, Human, Recombinant

Cat.No: TMPJ-00464

Species: Human

Expression System: E. coli

APX2, cytosolic Protein, Arabidopsis thaliana, Recombinant (His)

Cat.No: TMPH-00096

Species: Arabidopsis thaliana

Expression System: E. coli

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