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Search Results for " ad1 "

Targets Recommended: Apoptosis Autophagy

8

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T35329L	EAD1 TFA(1644388-26-0 Free base) EAD1 HCL(1644388-26-0 Free base)	Apoptosis; Autophagy	Apoptosis; Autophagy
	EAD1 HCL 是一种有效的自噬 (autophagy) 抑制剂，在肺癌和胰腺癌细胞中具有抗增殖活性。EAD1 HCL 还诱导凋亡 (apoptosis)。
T41180	JQAD1	Epigenetic Reader Domain	Chromatin/Epigenetic
	JQAD1是一种有效的、选择性的组蛋白乙酰转移酶 EP300降解剂（PROTAC；DC50≤31.6nM）；其包含 EP300抑制剂A485，通过连接体连接至脑啡肽E3连接酶配体。JQAD1以蛋白酶体依赖的方式导致神经母细胞瘤细胞系中EP300的降解。JQAD1抑制H3K27ac 和EP300的表达水平并诱导细胞凋亡。JQAD1抑制Kelly 细胞异种移植的NSG 小鼠的肿瘤生长。CRC 和MYCN 基因表达水平在JQAD1治疗的肿瘤中下调。JQAD1在诱导EP300降解的浓度下对共活化剂CBP 没有显著影响。
T78915	AD186	Sigma receptor	GPCR/G Protein
	AD186, 作为一种选择性S1R激动剂，具有高效率，其Ki值对 S1R 为2.7 nM，对 S2R 为27 nM。同时，AD186 能够完全抵消BD-1063对痛觉异常的抑制作用。
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
T83753	RAD17-derived Peptide TFA
	RAD17衍生肽是一种针对共济失调-毛细血管扩张及RAD3相关蛋白/激酶(ATR)的肽类底物。它已被用于识别ATR的抑制剂。
T35329	EAD1	Autophagy	Autophagy
	EAD1是一种有效的自噬（autophagy）抑制剂，在 BxPC3细胞中 IC50为5.8 μM。它在肺癌和胰腺癌细胞中具有抗增殖活性。
T81885	Mad1 (6-21) (TFA)
	Mad1 (6-21) TFA，作为Mad1蛋白的6-21片段，与哺乳动物Sin3A PAH2结合，其Kd约为29 nM。
T41012	Mad1 (6-21) Mad1 (6-21)
	Mad1 (6-21) is a peptide fragment derived from the Mad1 protein, specifically encompassing residues 6 to 21. This fragment exhibits binding affinity towards the mammalian Sin3A PAH2 domain, with a Kd value of approximately 29 nM.

化合物

EAD1 TFA(1644388-26-0 Free base)

Cat.No: T35329L

Synonym: EAD1 HCL(1644388-26-0 Free base)

Target: Apoptosis, Autophagy

Cat.No: T41180

Target: Epigenetic Reader Domain

Cat.No: T78915

Target: Sigma receptor

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

RAD17-derived Peptide TFA

Cat.No: T83753

Cat.No: T35329

Target: Autophagy

Mad1 (6-21) (TFA)

Cat.No: T81885

Cat.No: T41012

Synonym: Mad1 (6-21)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00668	APP/Protease nexin-II Protein, Human, Recombinant (hFc) CTFγ,amyloid beta (A4) precursor protein,AAA,ABPP,CVAP,APPI,...	Human	HEK293 Cells
	APP/Protease nexin-II Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 101 kDa and the accession number is P05067-8.
TMPY-03884	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) CTFgamma,PN-II,AAA,Aβ,PN2,APPI,AD1,amyloid...	Human	E. coli
	Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.2 kDa and the accession number is P05067-1.
TMPY-02221	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) CVAP,PN2,amyloid β (A4) precursor protein,Aβ,CTFγ,β-amyloid ...	Human	E. coli
	Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.4 kDa and the accession number is P05067-1.
TMPY-03885	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) AD1,AAA,ABETA,CVAP,PN-II,CTFgamma,Aβ,APPI,...	Human	E. coli
	Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 32.1 kDa and the accession number is P05067-1.
TMPY-02110	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) AD1,ABPP,CTFγ,APPI,ABETA,β-amyloid 40/β-AP...	Human	E. coli
	Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 31.8 kDa and the accession number is P05067-1.
TMPH-03060	NaD1 Protein, Nicotiana alata, Recombinant (His & SUMO)	Nicotiana alata	E. coli
	Plant defense peptide with antifungal activity against F.oxysporum and B.cinerea. Retards the growth of the Lepidopteran insect pests H.armigera and H.punctigera.
TMPH-01190	Human cytomegalovirus (HCMV) (strain AD169) glycoprotein H/gH Protein (His & SUMO)	HHV-5	E. coli
	Human cytomegalovirus (HCMV) (strain AD169) glycoprotein H/gH Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 35.8 kDa and the accession number is P12824.
TMPH-02222	TEAD1 Protein, Human, Recombinant (His)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expr...
TMPJ-01129	SMAD1 Protein, Human, Recombinant (GST) hSMAD1,Transforming Growth Factor-Beta-Sig...	Human	E. coli
	SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcriptional modulator SMAD 1 is activated by bone morphogenetic proteins type 1 receptor kinase. Defects in SMAD1 may cause primary pulmonary hypertension (PPH1), characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated ...
TMPH-01193	Human cytomegalovirus (HCMV) (strain AD169) Uncharacterized protein UL128 (His)	HHV-5	E. coli
	Human cytomegalovirus (HCMV) (strain AD169) Uncharacterized protein UL128 (His) is expressed in E. coli.
TMPH-01321	FLAD1 Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. FLAD1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.3 kDa and the accession number is Q8NFF5.
TMPH-01194	Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO)	HHV-5	E. coli
	Plays a role in viral entry into host cells. Forms a pentameric complex at the surface of the viral envelope together with gH, gL, UL130 and UL131. This complex is required for entry in epithelial, endothelial and myeloid host cells. Mechanistically, engages host receptor(s) including neurophilin 2/NRP2 to mediate infection. Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 37....
TMPH-01192	Human cytomegalovirus (HCMV) (strain AD169) Large structural phosphoprotein (Avi & His & MBP), Biotinylated	HHV-5	E. coli
	Human cytomegalovirus (HCMV) (strain AD169) Large structural phosphoprotein (Avi & His & MBP), Biotinylated is expressed in E. coli.

重组蛋白

APP/Protease nexin-II Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00668

Species: Human

Expression System: HEK293 Cells

Beta-amyloid 39/Beta-APP39 Protein, Human, Recombinant (aa 672-710, His & GST)

Cat.No: TMPY-03884

Species: Human

Expression System: E. coli

Beta-amyloid 42/Beta-APP42 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02221

Species: Human

Expression System: E. coli

Beta-amyloid 38/Beta-APP38 Protein, Human, Recombinant (aa 672-709, His & GST)

Cat.No: TMPY-03885

Species: Human

Expression System: E. coli

Beta-amyloid 40/Beta-APP40 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02110

Species: Human

Expression System: E. coli

NaD1 Protein, Nicotiana alata, Recombinant (His & SUMO)

Cat.No: TMPH-03060

Species: Nicotiana alata

Expression System: E. coli

Human cytomegalovirus (HCMV) (strain AD169) glycoprotein H/gH Protein (His & SUMO)

Cat.No: TMPH-01190

Species: HHV-5

Expression System: E. coli

TEAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-02222

Species: Human

Expression System: E. coli

SMAD1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01129

Species: Human

Expression System: E. coli

Human cytomegalovirus (HCMV) (strain AD169) Uncharacterized protein UL128 (His)

Cat.No: TMPH-01193

Species: HHV-5

Expression System: E. coli

FLAD1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01321

Species: Human

Expression System: E. coli

Human cytomegalovirus (HCMV) (strain AD169) UL130 Protein (His & SUMO)

Cat.No: TMPH-01194

Species: HHV-5

Expression System: E. coli

Human cytomegalovirus (HCMV) (strain AD169) Large structural phosphoprotein (Avi & His & MBP), Biotinylated

Cat.No: TMPH-01192

Species: HHV-5

Expression System: E. coli

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