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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T62743	AChE-IN-10
	AChE-IN-10 (Compound 24r) 是一种 AChE 的有效抑制剂，其 IC50 值为 2.4 nM。AChE-IN-10 在 AChE 存在下能够降低淀粉样蛋白的聚集。AChE-IN-10 对 AChE 表现出有效抑制作用，可以降低 S396 残基的 tau 磷酸化，挽救神经元形态和增加细胞活力，进而提供神经保护作用。
T61969	AChE/BChE-IN-10	AChR; AChE	Neuroscience
	AChE/BChE-IN-10 (Compound 7b) 是有效的、血脑屏障渗透性的 AChE 和 BChE 双重抑制剂，IC50 值分别为 0.176 和 0.47 μM。AChE/BChE-IN-10 可以抑制 Aβ 的聚集。
T62541	AChE-IN-22
	AChE-IN-22 (compound 10q) 是一种乙酰胆碱酯酶 (AChE) 的选择性抑制剂，能够作用于 AChE (IC50: 0.88 μM) 和 BuChE (IC50: 10 μM)。AChE-IN-22 能够同时与 AChE 的 CAS (catalytic active site) 和 PAS (peripheral anionic site) 位点结合，可用于研究阿尔茨海默病。
T78860	MAO-B-IN-24	Monoamine Oxidase	Neuroscience
	MAO-B-IN-24（化合物11h）为针对MAO-B的选择性、可逆性竞争抑制剂，抑制常数（IC50）为1.60 μM。该化合物同样对MAO-A表现出一定抑制效果（22.42 μM），并在10 μM的浓度时分别降低了AChE和BChE的活性至54.58%及88.43%。
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids that possess radical scavenging, amyloid-β aggregation inhibitory, and/or β-secretase 1 (BACE1) inhibitory activities in addition to their activity as AChE inhibitors.2,3 1.Recanatini, M., Cavalli, A., Belluti, F., et al.SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylchol...

化合物

Target: AChR, AChE

Target: Monoamine Oxidase

6,9-Dichloro-1,2,3,4-tetrahydroacridine

Cat.No: T35975

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
TN4286	Isodunnianol	NOS; NF-κB; ROS; AChR	Immunology/Inflammation; Neuroscience; NF-κB
	Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0.1 to 10 uM in the primary cultured rat cortical neurons. Isodunnianol, dunnianol, and Macrant