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Cat. No. | Product Name | Target | Signaling Pathways |
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T76995 |
Sotatercept
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Sotatercept (ACE-011) 是一种可溶性激活素受体 2A (ACVR2A) 型 IgGFc 融合蛋白。Sotatercept 结合了激活素和生长分化因子,试图恢复生长促进和生长抑制信号通路之间的平衡。Sotatercept 在肺动脉高压、贫血、骨质流失、红细胞生成、多发性骨髓瘤 (MM) 溶骨性病变中有潜在的应用。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00315 |
ACVR2A Protein, Human, Recombinant (hFc & His)
ACTR-IIA,Activin Receptor Type IIA,ACTRIIA,Activin Receptor ... |
Human | HEK293 Cells |
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors.... | |||
TMPY-01447 |
ACVR2A Protein, Mouse, Recombinant (His)
ActrIIa,activin A receptor, type IIA,Acvr2,TactrII |
Mouse | HEK293 Cells |
ACVR2A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is A2AI38. | |||
TMPY-01744 |
ACVR2A Protein, Human, Recombinant (His)
activin A receptor, type IIA,ACVR2,ACTRII |
Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.9 kDa and the accession number is P27037-1. | |||
TMPY-00659 |
ACVR2A Protein, Human, Recombinant (hFc)
ACVR2,ACTRII,activin A receptor, type IIA |
Human | HEK293 Cells |
ACVR2A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 40.0 kDa and the accession number is P27037-1. | |||
TMPY-01602 |
ACVR2A Protein, Mouse, Recombinant (His & hFc)
Acvr2,activin A receptor, type IIA,ActrIIa,TactrII |
Mouse | HEK293 Cells |
ACVR2A Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 41.4 kDa and the accession number is A2AI38. | |||
TMPH-01413 |
GDF11 Protein, Human, Recombinant (His & SUMO)
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Human | E. coli |
Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues. It is required for proper vertebral patterning and orofacial development. Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3. GDF11 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression... |