Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10498 |
5-HT2A antagonist 1
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
5-HT2A antagonist 1 is a 5-HT2A antagonist. It may be useful in the treatment of gastrointestinal disorders circulatory disorders. | |||
T15414 |
GR 113808
GR-113808 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
GR 113808 是一种具有选择性的 5-HT4 receptor 拮抗剂,抑制 5-HT1B,5-HT2A,5-HT2C 和 5-HT3 受体,可减弱多巴胺释放。 | |||
T4978 |
Sarpogrelate hydrochloride
盐酸沙格雷酯,MCI-9042 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂,可用于研究与血栓形成有关的血管疾病,对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。 | |||
T22921 |
LE 300
|
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
LE 300 是选择性多巴胺 D1 样受体拮抗剂,作用于人多巴胺 D1 和 D5 受体的Kis 分别为 1.9 nM 和 7.5 nM。在大鼠尾动脉实验中,它作用于5-HT2A 受体的pA2 为 8.32。 | |||
T61207 |
5-HT6/5-HT2A receptor ligand-1
|
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5-HT6/5-HT2A receptor ligand-1 (compound 33) is a dual antagonist for the 5-HT6 and 5-HT2A receptors. It exhibits a K i value of 2 nM and 11 nM for the respective receptors. This compound holds promise for research in neurological and psychiatric disorders [1]. | |||
T61837 | 5-HT6/5-HT2AR antagonist-1 | ||
5-HT6/5-HT2AR antagonist-1 is a powerful and effective compound that acts as a dual antagonist for both the 5-HT6 and 5-HT2A receptors. It exhibits high potency with K i values of 11 nM and 39 nM for the respective receptors [1]. | |||
T61220 | 5-HT6/5-HT2A receptor ligand-2 | ||
5-HT6/5-HT2A receptor ligand-2 (化合物 42) 是一种可透过血脑屏障的5-HT6/5-HT2A 的双拮抗剂 ,Ki 值分别为 25 nM 和 32 nM。5-HT6/5-HT2A receptor ligand-2 具有促认知特性。 | |||
T11295 |
Flibanserin-d4
BIMT-17BS D4,BIMT-17 D4,Flibanserin D4 |
Others | Others |
Flibanserin, a compound identified as BIMT-17, acts as a complete agonist at the serotonin 5-HT1A receptor, with a binding affinity (Ki) of 1 nM, while functioning as an antagonist at the 5-HT2A receptor with a 49 nM affinity. Flibanserin D4 represents a deuterium-labeled version of Flibanserin. | |||
T22044 |
BGC 20-761
|
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BGC20-761 是一种选择性的5-HT6和多巴胺受体 (dopamine receptor) 拮抗剂,对人 5-HT6,5-HT2A,D2 受体的Ki 值分别为 20,69,和 140 nM。BGC20-761 可增强长期记忆。BGC20-761 具有作为抗精神病药物的潜在效用。 | |||
T37114 |
SB 242084 dihydrochloride
|
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SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively.IC50 value: 9.0(pKi) [1]Target: 5-HT2C antagonistin vitro: SB 242084 had over 100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors. In studies of 5-HT-stimulated phosphatidylinositol hydrolysis using SH-SY5Y cells stably expressing the cloned human 5-HT2C receptor, SB 242084 acted as an antagonist with a pKb of 9.... | |||
T74668 | Zicronapine fumarate | ||
Zicronapine (Lu 31-130) fumarate 是抗精神病药,主要通过拮抗多巴胺D1/D2受体和5-HT2A受体发挥作用,在动物模型中显示出显著的前认知效果,展现出治疗多种神经和精神疾病的可能性。 | |||
T62324 |
Flibanserin hydrochloride
|
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Flibanserin (BIMT-17; BIMT-17BS) hydrochloride 是一种口服具有活力的 5-羟色胺的 5-HT1A 受体激动剂 (Ki: 1 nM) 和 5-HT2A (Ki: 49 nM) 受体拮抗剂。Flibanserin hydrochloride 同时可以结合多巴胺 D4 受体 (Ki: 4-24 nM)。Flibanserin hydrochloride 具有抗抑郁和抗焦虑的效果,能够用于性欲减退 (HSDD) 的研究。 | |||
T63115 |
Perphenazine dihydrochloride
|
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Perphenazine dihydrochloride 是一种口服具有活力的多巴胺受体 (dopamine receptor) 和组胺-1 受体 (histamine-1 receptor) 拮抗剂,作用于 D2 (Ki: 0.56 nM)、D3 (Ki: 0.43 nM)、5-HT2A (Ki: 0.6 nM)。Perphenazine dihydrochloride 也能够结合 Alpha-1A 肾上腺素受体。Perphenazine dihydrochloride 能够诱导细胞凋亡,并抑制癌细胞增殖。Perphenazine dihydrochloride 能够用于研究精神疾病、癌症、炎症。 | |||
T60576 |
Cyproheptadine
|
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Cyproheptadine 是一种有效的口服活性5-HT2A 受体拮抗剂。Cyproheptadine 具有抗抑郁和抗血清素作用。Cyproheptadine 还具有抗血小板和血栓保护活性,可用于研究血栓栓塞性疾病。 |