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12

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T38958	DMT-2′Fluoro-dU Phosphoramidite 2'-F-dU Phosphoramidite	Nucleoside Antimetabolite/Analog	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	DMT-2′Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) 可用于核苷修饰。
T39912	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine 5'-O-DMT-dU,保护-2'-脱氧尿苷	Others	Others
	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine (5'-O-DMT-dU) 是大肠杆菌 dUTP 核苷酸水解酶的竞争性抑制剂，Ki 高于 1000 μM。它通过合成核苷亚磷酰胺嵌段用于机器辅助的 DNA 合成。
TNU1305	2’-Fluoro-2-thio-2’-dU-3’-phosphoramidite
	Nucleoside Phosphoramidites
TNU1414	5-Me-3’-dU-2’-phosphoramidite
	Nucleoside Phosphoramidites
T2368L	Edoxaban Lixiana,依杜沙班	Factor Xa; Thrombin	Metabolism; Proteases/Proteasome
	Edoxaban (Lixiana) (DU-176) 是一种选择性的，口服有效的 factor Xa (FXa)抑制剂。Edoxaban 对游离 FXa 和凝血酶原的 Ki 分别为 0.561 nM 和 2.98 nM。Edoxaban 是一种抗凝剂，可用于预防中风。Edoxaban 还是一种凝血酶和凝血因子 IXaβ (FIXa) 的弱抑制剂，Ki 值分别为 6.00 μM 和 41.7 μM，对 FXa 的选择性超过 10000 倍。由于具有抗血栓形成的特性，Edoxaban 可用于预防血栓栓塞性疾病的研究。
T37175	Edoxaban impurity 4
	Edoxaban impurity 4, an impurity of Edoxaban (DU-176), is a selective, potent, and orally active inhibitor of factor Xa (FXa), exhibiting Kis of 0.561 nM for free FXa and 2.98 nM for prothrombinase. As an anticoagulant agent, Edoxaban is utilized for stroke prevention[1][2].
T37176	Edoxaban impurity 6
	Edoxaban impurity 6 is an impurity of Edoxaban. Edoxaban (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with Kis of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and can be used for stroke prevention[1][2]. [1]. Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.[2]. Mendell J, Lee F, Chen S, The Effe...
T63391	Calpain Inhibitor-2
	Calpain Inhibitor-2 是具有亲脂性的钙蛋白酶抑制剂，与黑色素瘤细胞系（A-375和B-16F1）和PC-3前列腺癌细胞相比，他们在体外具有中等到良好的抗增殖效果。Calpain Inhibitor-2 中的化合物3，在基质胶细胞侵袭测定中以2μM 浓度能够抑制了80%的DU-145细胞侵袭。
T70222	Ethonafide
	Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in multidrug-resistant cancer cell lines and the absence of a quinone and hydroquinone moiety make ethonafide a potentially less cardiotoxic replacement for existing anthracene-containing anticancer agents. Ethonafide was cytotoxic against three human prostate cancer cell lines at nanomolar concentrations. Ethonafide was found to be better tolerat...
T36380	GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)
	GLP-1 amide is a peptide hormone cleaved from proglucagon in the pancreas.1,2 Mice lacking the glucagon receptor (Gcgr-/-) have approximately nine-fold higher levels of total GLP-1 amide, including GLP-1 (1-36) amide and truncated GLP-1 (7-36) amide , in pancreatic tissue compared to wild-type mice.2References1. Schjoldager, B.T., Mortensen, P.E., Christiansen, J., et al. GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans...
T37594	Pericosine A
	Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable t...
T63392	Chitin synthase inhibitor 5
	Chitin synthase inhibitor 5 是一种几丁质合成酶的抑制剂 (IC50: 0.14 mM)。Chitin synthase inhibitor 5 表现出广谱的真菌抗活性，能够较好的抑制白色念珠菌、黄曲霉、烟毒念珠菌和新生念珠菌，能够用于研究真菌。

化合物

DMT-2′Fluoro-dU Phosphoramidite

Cat.No: T38958

Synonym: 2'-F-dU Phosphoramidite

Target: Nucleoside Antimetabolite/Analog

5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine

Cat.No: T39912

Synonym: 5'-O-DMT-dU,保护-2'-脱氧尿苷

Target: Others

2’-Fluoro-2-thio-2’-dU-3’-phosphoramidite

Cat.No: TNU1305

5-Me-3’-dU-2’-phosphoramidite

Cat.No: TNU1414

Cat.No: T2368L

Synonym: Lixiana,依杜沙班

Target: Factor Xa, Thrombin

Edoxaban impurity 4

Cat.No: T37175

Edoxaban impurity 6

Cat.No: T37176

Calpain Inhibitor-2

Cat.No: T63391

Cat.No: T70222

GLP-1 (1-36) amide (human, rat) (trifluoroacetate salt)

Cat.No: T36380

Cat.No: T37594

Chitin synthase inhibitor 5

Cat.No: T63392

Cat. No.	Product Name	Target	Signaling Pathways
T1721	2'-Deoxyuridine Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	2'-Deoxyuridine (2-deoxyuridine) 可以促使染色体断裂，从而抑制 thymidylate 的合成活性，它也是合成 Edoxudine 的前体。
T1174	Topotecan hydrochloride SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl	Apoptosis; Topoisomerase; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair
	Topotecan hydrochloride (NSC609699) 是一种具有抗癌活性的拓扑异构酶I 抑制剂。

天然产物

2'-Deoxyuridine

Cat.No: T1721

Synonym: Uracil deoxyriboside,2-deoxyuridine,2'-dU,2'-脱氧尿苷

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Topotecan hydrochloride

Cat.No: T1174

Synonym: SKF 104864A,SKFS 104864A,NSC609699,Nogitecan HCl,NSC 609669,盐酸拓扑替康,Topotecan HCl

Target: Apoptosis, Topoisomerase, Autophagy

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