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Search Results for " 1a1 "

18

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9704	1-Ethynylpyrene	P450	Metabolism
	1-Ethynylpyrene 是有效的细胞色素P450 1A1, 1A2和2B1抑制剂，抑制的IC50分别为 0.18，0.32 和 0.04 μM。
T22774L	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) 是延伸因子 1 亚基。真核翻译延伸因子 1 alpha 1 (EEF1A1) 编码延伸因子 alpha 亚基的同种型- 1 复合物，负责将氨酰 tRNA 酶促递送至核糖体。这种亚型（α 1）在脑、胎盘、肺、肝、肾和胰腺中表达，另一种亚型（α 2）在脑、心脏和骨骼肌中表达。这种亚型在 66% 的 Felty 综合征患者中被鉴定为自身抗原。已发现该基因在许多染色体上具有多个拷贝，其中一些（如果不是全部）代表不同的假基因。
T27109	CYP1A1 inhibitor 8a
	CYP1A1 inhibitor 8a is a potent and selective CYP1A1 inhibitor. It antagonizes B[a]P mediated activation of aromatic hydrocarbon receptor (AhR) in yeast cells, thereby protects human cells from CYP1A1-mediated B[a]P toxicity.
T22774	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]	Others	Others
	eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed
T63341	ALDH1A1-IN-2	Dehydrogenase	Metabolism
	ALDH1A1-IN-2 是一种有效的醛脱氢酶 1a1 (aldh1a1) 抑制剂，具有抗癌活性。ALDH1A1-IN-2 可用于研究乳腺癌、炎症或肥胖症。
T64228	ALDH1A1-IN-3
	ALDH1A1-IN-3 是一种良好的、选择性的醛脱氢酶 1A1 (ALDH1A1) 抑制剂 (IC50: μM)。ALDH1A1-IN-3 可以有效的改善 HepG2 细胞的葡萄糖消耗。ALDH1A1-IN-3 能够用于进行改善糖代谢的研究。
T61287	CYP121A1-IN-1
	CYP121A1-IN-1 是一种有效的CYP121A1抑制剂，对抗结核分枝杆菌具有良好的活性 (H37RvMIC90～6.25 μM, ～2.2 μg/mL)。CYP121A1-IN-1 通过抑制 CYP121A1 介导的环(l-酪氨酸-l-酪氨酸)转化为真菌环素，可显著减少真菌环素的产生。
T78204	CYP11A1-IN-1
	CYP11A1-IN-1（化合物30）是一种针对CYP11A1的抑制剂，其IC50为201-2000 nM。该化合物主要应用于类固醇受体研究，尤其适用于雄激素受体依赖性疾病，例如前列腺癌的研究。
T6903	NCT-501 NCT501	Dehydrogenase	Metabolism
	NCT-501 是一种茶碱类化合物，有效抑制醛脱氢酶 1A1(ALDH1A1), 抑制 hALDH1A1 IC50为 40 nM, 选择性超过其它 ALDH 同工酶和其它脱氢酶 (作用于 hALDH1B1, hALDH3A1, 和 hALDH2 时,IC50值 >57 UM)。
T23903	CM037 CM-037,A-37,CM 037,A37,A 37	Dehydrogenase	Metabolism
	CM037 (A-37) 是一种选择性 ALDH1A1 (乙醛脱氢酶 1A1) 的抑制剂(IC50;4.6 µM),具有抗肿瘤活性，可用于研究消除妇科恶性肿瘤。
T24988	7ETMC 7 ETMC,7-ETMC
	7ETMC is a selective Human Cytochrome P450s 1A1 and 1A2 inhibitor. 7ETMC showed IC50s of 0.46 μM and 0.50 μM for P450s 1A1 and 1A2 in the first six minutes, respectively, and did not show any inhibition activity for P450s 2A6 and 2B1 even at the dose of 5
T12197	NCT-506	Others	Others
	NCT-506 is an orally bioavailable inhibitors of aldehyde dehydrogenase 1A1 (ALDH1A1) (IC50 of 7 nM).
T23901	CM026 CM 026,CM-026
	CM026 is a selective aldehyde dehydrogenase 1A1 inhibitor that acts by binding within the aldehyde binding pocket of ALDH1A1 in an uncompetitive partial mode of inhibition.
T19685	Faldaprevir BI-201335,BI201335,BI 201335
	Faldaprevir is an effective NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T71215	Faldaprevir sodium
	Faldaprevir sodium is a potent NS3/NS4A protease inhibitor potentially for the treatment of HCV infection. Faldaprevir is known to inhibit P-glycoprotein, CYP3A4, and UDP-glucuronosyltransferase 1A1.
T39485	NCT-501 hydrochloride
	NCT-501 hydrochloride is a highly potent and selective inhibitor of aldehyde dehydrogenase 1A1 (ALDH1A1), which is based on theophylline. It effectively inhibits hALDH1A1 with an IC50 value of 40 nM, exhibiting superior selectivity towards hALDH1A1 compared to other ALDH isozymes and dehydrogenases such as hALDH1B1, hALDH3A1, and hALDH2 (with IC50 values exceeding 57 μM).
T62328	Cabotegravir sodium
	Cabotegravir sodium 是一种 HIV 整合酶的高效抑制剂，能够作用于 HIVADA (IC50: 2.5 nM)。Cabotegravir sodium 主要由尿苷二磷酸葡萄糖醛酸转移酶 (UGT) 1A1 代谢，与其他抗逆转录病毒药物 (ARVs) 相互作用的可能性较小。
T70313	Indoxyl Sulfate-d5 potassium salt
	Indoxyl sulfate-d5 is intended for use as an internal standard for the quantification of indoxyl sulfate by GC- or LC-MS. Indoxyl sulfate is a uremic toxin and a metabolite of tryptophan. It is formed via sulfation of indole, an intermediate generated from tryptophan by intestinal bacteria, by the sulfotransferase (SULT) isoform 1A1 variant 2 (SULT1A1*2) in the liver. Indoxyl sulfate activates the aryl hydrocarbon receptor (AhR) in HepG2 40/6 hepatoma cells (EC50 = 12.1 nM in a reporter assay). ...

化合物

1-Ethynylpyrene

Cat.No: T9704

Target: P450

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]（TFA)

Cat.No: T22774L

Target: Others

CYP1A1 inhibitor 8a

Cat.No: T27109

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species]

Cat.No: T22774

Target: Others

Cat.No: T63341

Target: Dehydrogenase

Cat.No: T64228

Cat.No: T61287

Cat.No: T78204

Cat.No: T6903

Synonym: NCT501

Target: Dehydrogenase

Cat.No: T23903

Synonym: CM-037,A-37,CM 037,A37,A 37

Target: Dehydrogenase

Cat.No: T24988

Synonym: 7 ETMC,7-ETMC

Cat.No: T12197

Target: Others

Cat.No: T23901

Synonym: CM 026,CM-026

Cat.No: T19685

Synonym: BI-201335,BI201335,BI 201335

Faldaprevir sodium

Cat.No: T71215

NCT-501 hydrochloride

Cat.No: T39485

Cabotegravir sodium

Cat.No: T62328

Indoxyl Sulfate-d5 potassium salt

Cat.No: T70313

Cat. No.	Product Name	Target	Signaling Pathways
T8038	7-Ethoxy-4-Methylcoumarin	Others	Others
	7-Ethoxy-4-Methylcoumarin 具有独特气味的芳香化合物。它被认为是细胞中酶的抑制剂，已被用于酶抑制的研究，并已被用于研究各种药物对人体的影响。
T4109	Rhapontigenin 3'-O-glucoside 丹叶大黄素 3'-O-葡萄糖苷,丹叶大黄素-3'-O-葡萄糖苷	Others	Others
	Rhapontigenin 3'-O-glucoside 是一种 Rhapontigenin 的衍生物，是 P450 1A1 抑制剂，可用于预防癌症。
T3776	Rhapontigenin 丹叶大黄素,Protigenin	P450; Antibacterial; Antifungal	Metabolism; Microbiology/Virology
	Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。
T0671	2-Naphthol Betanaphthol,β-萘酚,乙萘酚	Others; Endogenous Metabolite	Metabolism; Others
	2-Naphthol (Betanaphthol) 是一种 naphthalene 的代谢物，由细胞色素 P450 亚型 (CYP 1A1，CYP 1A2，CYP 2A1，CYP 2E1 和 CYP 2F2) 催化而成。
T4S0145	Corylifol A Corylinin,补骨脂异黄酮A	hCE; STAT; UGT	JAK/STAT signaling; Metabolism; Stem Cells
	Corylifol A (Corylinin) 是补骨脂中的一种天然产物，可抑制IL-6 诱导的STAT3激活和磷酸化，IC50值为0.81 μM。
T82305	Glucoarabin
	Glucoarabin是一种硫代葡萄糖苷，具备生物活性。在Hepa1c1c7细胞内，Glucoarabin的水解产物能够上调NQO1，而对细胞色素P450 (CYP) 1A1的活性无显著作用。

天然产物

7-Ethoxy-4-Methylcoumarin

Cat.No: T8038

Target: Others

Rhapontigenin 3'-O-glucoside

Cat.No: T4109

Synonym: 丹叶大黄素 3'-O-葡萄糖苷,丹叶大黄素-3'-O-葡萄糖苷

Target: Others

Cat.No: T3776

Synonym: 丹叶大黄素,Protigenin

Target: P450, Antibacterial, Antifungal

Cat.No: T0671

Synonym: Betanaphthol,β-萘酚,乙萘酚

Target: Others, Endogenous Metabolite

Cat.No: T4S0145

Synonym: Corylinin,补骨脂异黄酮A

Target: hCE, STAT, UGT

Cat.No: T82305

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