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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6042	[11C]MP 10 Mardepodect,PF-2545920	PDE	Metabolism
	[11C]MP 10 (PF-2545920) 是一种特异性且有效的 PDE10A 抑制剂 (IC50=0.37 nM)，其特异性活性是 PDE 的 1000 倍以上。
T29476	6-OH-BTA-0 Pittsburgh Compound-B precursor,11C-PiB Precursor
	6-OH-BTA-0 is the precursor for preparing 11C-PiB, which is a β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.
T21000	PiB 2-(4-(二甲基氨基)苯基)苯并[D]噻唑-6-醇,Pittsburgh Compound-B,6-OH-BTA-1	Others	Others
	PiB (Pittsburgh Compound-B) 是分析 11C-PiB 的标准品。 11C-PiB 是一种用于阿尔茨海默病诊断的 β-淀粉样蛋白 PET 成像示踪剂。
T31389	Desmethyl-HD-800 Desmethyl-HD800,Desmethyl HD800
	Desmethyl-HD-800 is a PET precursor of preparing radiolabel [11C]HD-800, a high affinity brain penetrant PET tracer for imaging microtubules.
T29258	(R)-N-Desmethyl PK11195 (R)-N-Desmethyl PK 11195,(R)-N-Desmethyl PK-11195,(R)-N Desmethyl PK11195,(R) N-Desmethyl PK11195
	(R)-N-Desmethyl PK11195 is a precursor for (R)-[N-Methyl-11C-]PK11195.
T32904	LSN3172176 Precursor LSN-3172176 Precursor,LSN 3172176 Precursor
	LSN3172176 Precursor is a precursor for 11C-radiolabelling LSN3172176 PET scan.
T81617	OfHex1-IN-1
	OfHex1-IN-1（化合物11c）是一种针对亚洲玉米螟β-N-乙酰己糖氨基酶OfHex1的高效选择性抑制剂，展现出28.1 μM的IC50和25.6 μM的Ki。该化合物适用于研发与OfHex1相关的绿色农药。
T79262	SSI-4	Stearoyl-CoA Desaturase (SCD)	Metabolism
	SSI-4为SCD1 (硬脂酰辅酶A去饱和酶1) 抑制剂，能够通过11C标记，用于SCD1体内小动物PET/CT成像的配体。
T36744	CDK9 Antagonist-1 CDK9 Antagonist-1
	CDK9 Antagonist-1 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1]. CDK9\|17 μM (IC50, MCF-7 cells) [1]. Bian J , et al. Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity. Bioorg Chem. 2018 Dec;81:373-381.
T17728	PROTAC CDK9 degrader-2	Others	Others
	PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
T78753	Aurora Kinases-IN-4	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Aurora Kinases-IN-4（Compound 11c）是共价ATP竞争型aurora kinaseA抑制剂，具有IC50为1.7 nM。该化合物对SJSA-1、MDA-MB-231、A549和HeLa细胞系的增殖抑制效果显著，其IC50分别为4.27、1.54、3.08和6.99 μM。Aurora Kinases-IN-4适用于三阴性乳腺癌（TNBC）的相关研究。

化合物

[11C]MP 10

Cat.No: T6042

Synonym: Mardepodect,PF-2545920

Target: PDE

6-OH-BTA-0

Cat.No: T29476

Synonym: Pittsburgh Compound-B precursor,11C-PiB Precursor

Target:

PiB

Cat.No: T21000

Synonym: 2-(4-(二甲基氨基)苯基)苯并[D]噻唑-6-醇,Pittsburgh Compound-B,6-OH-BTA-1

Target: Others

Desmethyl-HD-800

Cat.No: T31389

Synonym: Desmethyl-HD800,Desmethyl HD800

Target:

(R)-N-Desmethyl PK11195

Cat.No: T29258

Synonym: (R)-N-Desmethyl PK 11195,(R)-N-Desmethyl PK-11195,(R)-N Desmethyl PK11195,(R) N-Desmethyl PK11195

Target:

LSN3172176 Precursor

Cat.No: T32904

Synonym: LSN-3172176 Precursor,LSN 3172176 Precursor

Target: Stearoyl-CoA Desaturase (SCD)

CDK9 Antagonist-1

Cat.No: T36744

Synonym: CDK9 Antagonist-1

Target:

PROTAC CDK9 degrader-2

Target: Aurora Kinase

Cat. No.	Product Name	Target	Signaling Pathways
T41078	Lipopolysaccharides, Escherichiacoli Lipopolysaccharide, E. coli O111:B4	Others	Others
	Lipopolysaccharides, Escherichiacoli (E. coli O111:B4) 是革兰氏阴性细菌细胞壁的一种特有成分，由脂质A、寡糖核心和 O -特异性多糖 (O-antigen) 3个区域组成。Lipopolysaccharides, Escherichiacoli 有利于维持细胞外膜的完整性，保护细菌免受胆汁盐和脂类抗生素的破坏。Lipopolysaccharides, Escherichiacoli 是一种高免疫原性抗原，可以增强免疫反应，可以用于炎症模型构建。

天然产物

Lipopolysaccharides, Escherichiacoli

Cat.No: T41078

Synonym: Lipopolysaccharide, E. coli O111:B4

Target: Others

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