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Search Results for " 11β-hydroxylase "

5

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T65816	Prolyl-4-hydroxylase Inhibitor 11	Others	Others
	Prolyl-4-hydroxylase Inhibitor 11 是一种新型脯氨酸4-羟化酶抑制剂，对普通小球藻(Chlorella vulgaris)氧化应激和 Cu(II)毒性的保护作用。
T4277	Osilodrostat LCI699	Glucocorticoid Receptor; Others; Hydroxylase	Endocrinology/Hormones; Metabolism; Others
	Osilodrostat (LCI699) 是一种有效的人11β-羟化酶和醛固酮合成酶抑制剂，IC50分别值为2.5 和0.7nM。
T28272	Osilodrostat phosphate LCI699 phosphate,LCI 699 phosphate,LCI-699 phosphate
	Osilodrostat phosphate is a potent oral 11β-hydroxylase inhibitor.
T33370	Metyrapol SU 5236,SU-5236,SU5236
	Metyrapol is a competitive inhibitor of 11-deoxycorticosterone hydroxylation by 11β-hydroxylase.
T30741	Carboetomidate
	Carboetomidate is an analog of etomidate and does not bind to 11β -hydroxylase with high affinity.

化合物

Prolyl-4-hydroxylase Inhibitor 11

Cat.No: T65816

Target: Others

Cat.No: T4277

Synonym: LCI699

Target: Glucocorticoid Receptor, Others, Hydroxylase

Osilodrostat phosphate

Cat.No: T28272

Synonym: LCI699 phosphate,LCI 699 phosphate,LCI-699 phosphate

Cat.No: T33370

Synonym: SU 5236,SU-5236,SU5236

Cat.No: T30741

Cat. No.	Product Name	Target	Signaling Pathways
T14001	11-Beta-hydroxyandrostenedione 4-雄烯-11β-醇-3,17-二酮,NSC-17102,4-Androsten-11β-ol-3,17-dione	Endogenous Metabolite	Metabolism
	11-Beta-hydroxyandrostenedione (NSC-17102) 是主要存在于肾上腺的类固醇，也是 11β-羟基类固醇脱氢酶同工酶抑制剂。随着 4-androstenedione 的提高，通过测量血浆中的11-Beta-hydroxyandrostenedione，能够区分高雄激素血症的肾上腺或卵巢起源。
T36915	21-Deoxycortisol
	21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive...
T36472	Tetrahydro-11-deoxy Cortisol
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA.

天然产物

11-Beta-hydroxyandrostenedione

Cat.No: T14001

Synonym: 4-雄烯-11β-醇-3,17-二酮,NSC-17102,4-Androsten-11β-ol-3,17-dione

Target: Endogenous Metabolite

21-Deoxycortisol

Cat.No: T36915

Tetrahydro-11-deoxy Cortisol

Cat.No: T36472

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