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35

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T60050	ANT3310	Antibacterial	Microbiology/Virology
	ANT3310 是一种广谱共价丝氨酸 β-内酰胺酶抑制剂，对 AmpC、CTX-M-15、TEM-1、OXA-48、OXA-23 和 KPC-2 的 IC50 范围为 1 nM 至 175 nM。 ANT3310 可用于细菌感染研究。
T0234	Methicillin sodium salt Methicillin sodium,Meticillin sodium,甲氧西林钠	Antibacterial; Antibiotic	Microbiology/Virology
	Methicillin sodium salt 是β-内酰胺抗生素，抑制参与肽聚糖合成的青霉素结合蛋白。
T14979	Clavulanate lithium Clavulanic acid lithium,克拉维酸锂	Antibacterial	Microbiology/Virology
	Clavulanate lithium (Clavulanic acid lithium) 是一种β-lactamase 的高效抑制剂，可作抗生素。
T4405	Ceftibuten dihydrate 头孢布烯二水合物,Sch-39720 dihydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftibuten dihydrate (Sch-39720 dihydrate) 是一种具有口服活性的头孢菌素，在体外对多种革兰氏阴性和某些革兰氏阳性病原体有抗菌活性。
T6438	Cefoselis Sulfate FK 037 Sulfate,FK-037,硫酸头孢噻利	Antibacterial; Antibiotic	Microbiology/Virology
	Cefoselis Sulfate (FK 037 Sulfate) 是一种头孢菌素 β-内酰胺抗生素。它对多种革兰氏阳性和革兰氏阴性生物均表现出良好的活性。它可以透过血脑屏障。
T6471	Dicloxacillin Sodium Veracillin,双氯西林,BRL1702 Sodium,BRL1702,Sodium dicloxacillin,双氯西林钠	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Dicloxacillin Sodium (BRL1702 Sodium) 是一种青霉素类窄谱β内酰胺抗生素, 用于革兰氏阳性菌感染的研究。它对β-内酰胺酶产生的微生物有抗菌作用。
T0827	Cefsulodin sodium Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠	Antibacterial; Antibiotic	Microbiology/Virology
	Cefsulodin sodium (Sulcephalosporin) 是β内酰胺抗生素，对缘脓杆菌和肠杆菌有活性。
T5570	Cephalothin 头孢噻吩,Cephalotin acid	Antibacterial; Antibiotic	Microbiology/Virology
	Cephalothin 是一种 β-内酰胺抗生素，抑制 C 类 β-内酰胺酶活性的 Ki 值为 0.32 µM。
T6385	Amoxicillin Sodium 阿莫西林钠,Clavulanate	Antibacterial; Antibiotic	Microbiology/Virology
	Amoxicillin Sodium (Clavulanate) 是一种有广谱抗菌活性，口服吸收好的抗生素。它能抑制细胞壁中多肽的生物合成，可抑制细胞生长。
T1001	Dicloxacillin Sodium hydrate Dicloxacillin sodium salt monohydrate,双氯西林钠,Dicloxacillin sodium monohydrate	Antibacterial; Antibiotic	Microbiology/Virology
	Dicloxacillin Sodium hydrate 是一种青霉素类窄谱β内酰胺抗生素，可研究革兰氏阳性菌感染。
T1305	Ceftazidime GR20263,头孢他啶	Antibacterial; Antibiotic	Microbiology/Virology
	Ceftazidime (GR20263) 是可静脉内或肌肉给药的第头孢菌素。它对革兰氏阳性和革兰氏阴性需氧细菌有体外活性。它对肠杆菌科特别有效，对大多数 β-内酰胺酶具有抗水解作用。
T6582	Mezlocillin Sodium 美洛西林钠,Baycipen	Antibacterial; Antibiotic	Microbiology/Virology
	Mezlocillin Sodium (Baycipen) 是一种青霉素 β-内酰胺类抗生素，用于治疗由易感染微生物引起的细菌感染。
T66175	Ceftriaxone Sodium	GSK-3; Antibiotic; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Microbiology/Virology; PI3K/Akt/mTOR signaling; Stem Cells
	Ceftriaxone Sodium 是一种广谱 β-内酰胺类三代头孢菌素类抗生素 (antibiotic)，具有抗炎、抗肿瘤、抗菌和抗氧化活性。Ceftriaxone Sodium 是一种共价 GSK3β和 Aurora B 抑制剂，可用于研究败血症和感染性心内膜炎。
T1631	Sulbactam CP45899,舒巴坦,舒巴坦酸	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T19860	Clavulanic Acid BRL 14151,MM-14151,MM 14151,RX-10100,MM14151,BRL14151,BRL-14151	Antibacterial; Antifungal	Microbiology/Virology
	Clavulanic Acid(RX-10100) 是一种由生物体克拉维链霉菌产生的主要β-内酰胺类抗生素，是一种强效的细菌 β-内酰胺酶抑制剂，用于研究细菌引起的感染。Clavulanic Acid 具有广谱的生物活性，对多种革兰氏阳性和革兰氏阴性细菌均有活性。
T28880	Sulfazecin free acid G 6302,Antibiotic G 6302,Sulfazecin,Antibiotic EM 5210
	Sulfazecin is a β-Lactam antibiotic.
T1070L	Cefmetazole Sodium, Cefmetazole,Cefmetazolum,Cefmetazolo
	Cefmetazole is a second-generation semi-synthetic β-lactam cephalosporin antibiotic with antimicrobial activity.
T16466	Penicillin G Procaine PGP	Others	Others
	Penicillin G Procaine is a β-lactam antibiotic and is a crystalline complex produced by chemically combining penicillin G with procaine.
T26980	Cephamycin C A 16886B,A16886B, A-16886B
	Cephamycin C (CepC) is a nontoxic β-lactam antibiotic. CepC stands out from other cephalosporins for its greater resistance to β-lactamases.
T0814L1	L-(+)-Ampicillin Ampicillin,L-Ampicillin
	L-(+)-Ampicillin is an isomer of Ampicillin. Ampicillin is a β-lactam antibiotic used for treating bacterial infections.
T21384	Dicloxacillin Dicloxacilina,Dicloxacycline,Dicloxacillinum,Dicloxacilline,Diclocil,Dynapen
	Dicloxacillin (INN), a narrow-spectrum β-Lactam antibiotic of the penicillin class, is used against beta-lactamase-producing organisms such as Staphylococcus aureus, which would otherwise be resistant to most penicillins.
T34270	Razupenem SMP601,SMP 601,PTZ601,PTZ 601,PTZ-601,SMP-601
	Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a
T38972	Cefalonium hydrate
	Cefalonium hydrate is a first-generation β-lactam cephalosporin antibiotic commonly employed in the study of bovine mastitis induced by Gram-positive bacteria, particularly staphylococci. It demonstrates significant effectiveness in this research area.
T70774	Clavicoronic acid
	Clavicoronic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor. While not effective by itself as an antibiotic, when combined with penicillin-group antibiotics, it can overcome antibiotic resistance in bacteria that secrete β-lactamase, which otherwise inactivates most penicillins.
T36600	Cefsulodin (sodium salt hydrate)
	Cefsulodin is a β-lactam antibiotic that lyses actively-growingE. coliby binding specifically to the intermembrane proteins, penicillin-binding proteins 1a and b, whose transglycosylase and transpeptidase activities are involved in cell elongation and septation.1Cefsulodin has been used in combination with other β-lactam antibiotics, such as cefazolin as a strategy to circumvent drug resistance.2
T38020	O-Benzylhydroxylamine (hydrochloride)
	O-Benzylhydroxylamine is a building block.1,2It has been used in the synthesis of β-lactam inhibitor precursors and fluoroquinolone derivatives with antibiotic activity. 1.Bellettini, J.R., and Miller, M.J.A short synthesis of an important precursor to a new class of bicyclic β-lactamase inhibitorsTetrahedron Lett.38(2)167-168(1997) 2.Asadipour, A., Moshafi, M.H., Khosravani, L., et al.N-substituted piperazinyl sarafloxacin derivatives: synthesis and in vitro antibacterial evaluationDaru.26(2)19...
T75391	Penicillinase
	Penicillinase 是一种 β-内酰胺酶。β-内酰胺酶通过水解特征性四元 β-内酰胺环的肽键使抗生素失效，从而使 β-内酰胺抗生素失活。
T32064	Hetacillin Hetacilina,Hetacilline,Hetacillinum,Phenazacillin,Versapen
	Hetacillin 是一种β-内酰胺抗生素，属于氨基青霉素家族，通过酯酶转化为氨苄西林。氨苄西林是一种没有抗菌活性的前药。
T73600	Cefaloglycin
	Cefaloglycin（Cephaloglycin）是一种β-内酰胺类（β-lactam）口服活性头孢菌素类抗生素，具有肾毒性和抗菌活性。该药物对革兰氏阳性球菌（除肠球菌外）有效，同时对线粒体底物摄取及呼吸具有毒性。
T74378	Temocillin
	Temocillin为6-α-甲氧基青霉素衍生物，为半合成β-内酰胺类抗生素，对多数需氧革兰氏阴性菌展现特定抗菌活性。
T68866	Ceftolozane
	Ceftolozane, also known as FR-264,205 and CXA-101; is an antibiotic drug from the cephalosporin family, approved for the treatment of infections with gram-negative bacteria, or gram-positive bacteria. Ceftolozane is of great benefit due to its ability to target bacteria that have become resistant to conventional antibiotics. Ceftolozane is combined with the β-lactamase inhibitor tazobactam, as multi-drug resistant bacterial infections will generally show resistance to all β-lactam antibiotics un...
T75324	Azidocillin
	Azidocillin 是一种半合成青霉素，是一种具有口服活性的 β-内酰胺类抗生素 (antibiotic)。Azidocillin 具有叠氮化功能，并在细菌内 (bacteria) 保持靶向活性。Azidocillin 可用于研究牙科手术引起的骨炎，或中耳炎、肠球菌败血症和其他细菌感染性疾病。
T36474	TunR1
	TunR1 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. TunR1 (5 μg/ml) is cytotoxic to MDA-MB-231 breast cancer cells and non-cancerous CHO cells. Unlike tunicamycin, TunR1 does not inhibit glycosylation in a protein N-glycosylation assay. 1.Price, N.P., Hartman, T.M., Li, J., et al.Modified...
T73859	Methicillin sodium hydrate
	Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。
T36475	TunR2
	TunR2 is an antibiotic and derivative of tunicamycin .1It is active againstB. subtilis(MIC = 0.3 μg/ml) and increases the efficacy of the β-lactam antibiotics oxacillin , methicillin , and penicillin G againstB. subtiliswhen used at a concentration of 0.4 μg/ml. Unlike tunicamycin, TunR2 is non-toxic toS. cerevisiae(MIC = >10 μg/ml) and does not inhibit glycosylation in a protein N-glycosylation assay. TunR2 also has reduced antiproliferative activity against MDA-MB-231 and CHO cells compared wi...

化合物

Cat.No: T60050

Target: Antibacterial

Methicillin sodium salt

Cat.No: T0234

Synonym: Methicillin sodium,Meticillin sodium,甲氧西林钠

Target: Antibacterial, Antibiotic

Clavulanate lithium

Cat.No: T14979

Synonym: Clavulanic acid lithium,克拉维酸锂

Target: Antibacterial

Ceftibuten dihydrate

Cat.No: T4405

Synonym: 头孢布烯二水合物,Sch-39720 dihydrate

Target: Antibacterial, Antibiotic

Cefoselis Sulfate

Cat.No: T6438

Synonym: FK 037 Sulfate,FK-037,硫酸头孢噻利

Target: Antibacterial, Antibiotic

Dicloxacillin Sodium

Cat.No: T6471

Synonym: Veracillin,双氯西林,BRL1702 Sodium,BRL1702,Sodium dicloxacillin,双氯西林钠

Target: Others, Antibacterial, Antibiotic

Cefsulodin sodium

Cat.No: T0827

Synonym: Cefsulodine sodium,Sulcephalosporin,头孢磺啶钠

Target: Antibacterial, Antibiotic

Cat.No: T5570

Synonym: 头孢噻吩,Cephalotin acid

Target: Antibacterial, Antibiotic

Amoxicillin Sodium

Cat.No: T6385

Synonym: 阿莫西林钠,Clavulanate

Target: Antibacterial, Antibiotic

Dicloxacillin Sodium hydrate

Cat.No: T1001

Synonym: Dicloxacillin sodium salt monohydrate,双氯西林钠,Dicloxacillin sodium monohydrate

Target: Antibacterial, Antibiotic

Cat.No: T1305

Synonym: GR20263,头孢他啶

Target: Antibacterial, Antibiotic

Mezlocillin Sodium

Cat.No: T6582

Synonym: 美洛西林钠,Baycipen

Target: Antibacterial, Antibiotic

Ceftriaxone Sodium

Cat.No: T66175

Target: GSK-3, Antibiotic, Aurora Kinase

Cat.No: T1631

Synonym: CP45899,舒巴坦,舒巴坦酸

Target: Antibacterial, Antibiotic

Clavulanic Acid

Cat.No: T19860

Synonym: BRL 14151,MM-14151,MM 14151,RX-10100,MM14151,BRL14151,BRL-14151

Target: Antibacterial, Antifungal

Sulfazecin free acid

Cat.No: T28880

Synonym: G 6302,Antibiotic G 6302,Sulfazecin,Antibiotic EM 5210

Cat.No: T1070L

Synonym: Sodium, Cefmetazole,Cefmetazolum,Cefmetazolo

Penicillin G Procaine

Cat.No: T16466

Synonym: PGP

Target: Others

Cat.No: T26980

Synonym: A 16886B,A16886B, A-16886B

L-(+)-Ampicillin

Cat.No: T0814L1

Synonym: Ampicillin,L-Ampicillin

Cat.No: T21384

Synonym: Dicloxacilina,Dicloxacycline,Dicloxacillinum,Dicloxacilline,Diclocil,Dynapen

Cat.No: T34270

Synonym: SMP601,SMP 601,PTZ601,PTZ 601,PTZ-601,SMP-601

Cefalonium hydrate

Cat.No: T38972

Clavicoronic acid

Cat.No: T70774

Cefsulodin (sodium salt hydrate)

Cat.No: T36600

O-Benzylhydroxylamine (hydrochloride)

Cat.No: T38020

Cat.No: T75391

Cat.No: T32064

Synonym: Hetacilina,Hetacilline,Hetacillinum,Phenazacillin,Versapen

Cat.No: T73600

Cat.No: T74378

Cat.No: T68866

Cat.No: T75324

Cat.No: T36474

Methicillin sodium hydrate

Cat.No: T73859

Cat.No: T36475

Cat. No.	Product Name	Target	Signaling Pathways
T0814	Ampicillin Trihydrate NCI-C56086,氨苄青霉素三水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Ampicillin Trihydrate (NCI-C56086) 是一种 β-内酰胺类广谱抗生素，可对抗多种革兰氏阳性和革兰氏阴性细菌。
T1029	Aztreonam SQ-26,776,氨曲南	Antibacterial; Antibiotic	Microbiology/Virology
	Aztreonam (SQ-26,776) 是单环β-内酰胺抗生素，与青霉素结合蛋白3有较高亲和力。

天然产物

Ampicillin Trihydrate

Cat.No: T0814

Synonym: NCI-C56086,氨苄青霉素三水合物

Target: Antibacterial, Antibiotic

Cat.No: T1029

Synonym: SQ-26,776,氨曲南

Target: Antibacterial, Antibiotic

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