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Cat. No. | Product Name | Target | Signaling Pathways |
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T83938 |
TAT-PDHPS1
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TAT-PDHPS1是一种针对Yes-associated protein (YAP) 信号的肽抑制剂。它由内源性肽PDHPS1和能穿透细胞的肽序列TAT组成。PDHPS1与蛋白磷酸酶2磷酸酶激活因子(PTPA)结合, 激活蛋白磷酸酶2A (PP2A)。该激活促进YAP的磷酸化和抑制YAP靶向基因的表达。TAT-PDHPS1能够抑制体外卵巢癌细胞的增殖和小鼠皮下异种移植肿瘤模型中的卵巢肿瘤生长。 |
Cat. No. | Product Name | Species | Expression System |
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TMPY-02511 |
PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)
LRP,PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His... |
Human | Baculovirus Insect Cells |
PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and anima... |