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Search Results for " il1 "
Targets Recommended: MyD88

1

抑制剂 & 化合物

24

重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T13063 T6167923

MyD88 Immunology/Inflammation
T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。

化合物

T6167923
Cat.No: T13063
Synonym:
Target: MyD88
Species：
Human (16)
Mouse (3)
Canine (1)
Cynomolgus (1)
Rabbit (1)
Rat (1)
Rhesus (1)
Expression System：
E. coli (13)
HEK293 Cells (8)
P. pastoris (Yeast) (2)
Baculovirus Insect Cells (1)
Tag：
Tag Free (8)
C-His (3)
N-His (3)
His (2)
hFc (2)
C-10xHis,C-Flag (1)
C-6xHis (1)
N-10xHis, C-Myc (1)
N-6xHis (1)
N-6xHis-SUMO (1)
Cat. No. Product Name Species Expression System
TMPY-06981 IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)

interleukin 1 α,IL1,白介素,IL

Human E. coli
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage...
TMPY-00854 IL-1 alpha/IL-1A Protein, Human, Recombinant

IL-1F1,interleukin 1, α,...

 Human HEK293 Cells
IL-1 alpha/IL-1A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18 kDa and the accession number is P01583.
TMPY-01049 IL-1 beta/IL-1F2 Protein, Human, Recombinant

IL-1 beta,interleukin 1, beta,

Human E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584.
TMPY-01999 IL-1 beta/IL-1F2 Protein, Human, Recombinant (His)

IL-1,IL1-β,白介素,IL

Human E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 32.3 kDa and the accession number is P01584.
TMPY-02879 IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)

interleukin 36, alpha,白细胞介素,FIL1(ε),IL...

 Human E. coli
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158) is expressed in E. coli expression system. The predicted molecular weight is 17.2 kDa and the accession number is Q9UHA7.
TMPY-04011 IL-1 beta/IL-1F2 Protein, Rabbit, Recombinant

白介素,IL1-β,interleukin 1, beta,int...

 Rabbit E. coli
IL-1 beta/IL-1F2 Protein, Rabbit, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P14628.
TMPJ-00909 IL-1RA Protein, Mouse, Recombinant

IL-1RN,IRAP,Interleukin-1 Recepto...

 Mouse E. coli
Interleukin-1 receptor antagonist protein (Il1rn), also known as IL-1ra, IRAP or IL1 inhibitor, is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. The mouse Il1rn gene encodes a 178 amino acids (aa) protein with a 26 aa signal peptide. Mouse Il1rn protein shares 26% and 19% identity with its homologues IL-1 beta and I...
TMPY-01956 IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant

IL1(ε),FIL1(ε),IL

Mouse E. coli
IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.
TMPY-04175 IL-1F10 Protein, Human, Recombinant (His)

FIL1-theta,IL1-θ,IL<...

 Human P. pastoris (Yeast)
IL-1F10 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 18.4 kDa and the accession number is AAK68048.1.
TMPY-02818 IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)

白细胞介素,FIL1,白介素,interleukin 36, α,IL

Human E. coli
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.2 kDa and the accession number is Q9UHA7.
TMPY-02817 IL-1F8 Protein, Human, Recombinant (His)

FIL1,FIL1H,IL

Human E. coli
IL-1F8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.3 kDa and the accession number is Q9NZH7-2.
TMPY-02458 IL-1F8 Protein, Human, Recombinant

FILI-(ETA),FIL1-(ETA),IL...

 Human E. coli
IL-1F8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.7 kDa and the accession number is Q9NZH7-2.
TMPK-00920 IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)

IL-1A,白介素,IL-1 alpha,Int...

 Cynomolgus HEK293 Cells
The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
TMPY-00855 IL-25/IL17E Protein, Mouse, Recombinant (His)

interleukin 25,IL-17e,Il1

Mouse HEK293 Cells
IL-25/IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.
TMPY-00843 IL-25/IL17E Protein, Human, Recombinant (hFc)

interleukin 25,IL17E

 Human HEK293 Cells
IL-25/IL17E Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9H293-1.
TMPY-02798 NEIL1 Protein, Human, Recombinant (His)

NEI1,nei endonuclease VIII-like 1 (E. coli...

 Human E. coli
NEIL1 is a member of DNA glycosylases. DNA glycosylases are a family homologous to the bacterial Fpg/Nei family. They play a role in base excision repair which is the mechanism by which damaged bases in DNA are removed and replaced. The first step of this process is catalyzed by DNA glycosylases. They remove the damaged nitrogenous base while leaving the sugar-phosphate backbone intact, creating an apurinic/apyrimidinic site, commonly referred to as an AP site. NEIL1 functions in base excision r...
TMPY-05563 IL-25/IL17E Protein, Canine, Recombinant (hFc)

interleukin 25,白细胞介素,白介素

 Canine HEK293 Cells
IL-25/IL17E Protein, Canine, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.2 kDa and the accession number is A0A8I3MRV2.
TMPY-03285 PPIL1 Protein, Human, Recombinant (His)

CGI-124,PPIase,CYPL1,hCyPX,peptidylprolyl ...

 Human E. coli
PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take a significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of...
TMPJ-00060 IL-25/IL17E Protein, Human, Recombinant (His)

白细胞介素,IL17E,白介素,IL-17E,<...

 Human HEK293 Cells
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins, which is comprised of six members (IL-17, IL-17B through IL-17F). These proteins are secreted and are structurally related by sharing a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. With the exception of IL-17B, which exists as a non-covalently linked dimer, all IL-17 family members are disulfide-linked dimers. IL-17 family proteins are pro-inflammator...
TMPH-01518 IL12A & IL12B Heterodimer Protein, Human, Recombinant (Flag & His)

Human HEK293 Cells
IL12A & IL12B Heterodimer Protein, Human, Recombinant (Flag & His) is expressed in HEK293 mammalian cells with C-10xHis and C-Flag tag. The predicted molecular weight is 39.7 kDa and 27.2 kDa and the accession number is P29460 P29459.
TMPY-03204 IL-25/IL17E Protein, Rat, Recombinant (hFc)

白介素,白细胞介素,interleukin 25

 Rat HEK293 Cells
IL-25/IL17E Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.1 kDa and the accession number is D3ZLB1.
TMPH-02438 IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO)

Rhesus E. coli
Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag...
TMPH-01558 IL12RB2 Protein, Human, Recombinant (His)

Human P. pastoris (Yeast)
Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. IL12RB2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 69.7 kDa and the accession number is Q99665.
TMPH-02194 TAB2 Protein, Human, Recombinant (His & Myc)

Human Baculovirus Insect Cells
Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1: this acts as a scaffold to organize a large signaling complex to ...

重组蛋白

IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
Cat.No: TMPY-06981
Species: Human
Expression System: E. coli
IL-1 alpha/IL-1A Protein, Human, Recombinant
Cat.No: TMPY-00854
Species: Human
Expression System: HEK293 Cells
IL-1 beta/IL-1F2 Protein, Human, Recombinant
Cat.No: TMPY-01049
Species: Human
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Human, Recombinant (His)
Cat.No: TMPY-01999
Species: Human
Expression System: E. coli
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (aa 6-158)
Cat.No: TMPY-02879
Species: Human
Expression System: E. coli
IL-1 beta/IL-1F2 Protein, Rabbit, Recombinant
Cat.No: TMPY-04011
Species: Rabbit
Expression System: E. coli
IL-1RA Protein, Mouse, Recombinant
Cat.No: TMPJ-00909
Species: Mouse
Expression System: E. coli
IL-36 alpha/IL-1F6 Protein, Mouse, Recombinant
Cat.No: TMPY-01956
Species: Mouse
Expression System: E. coli
IL-1F10 Protein, Human, Recombinant (His)
Cat.No: TMPY-04175
Species: Human
Expression System: P. pastoris (Yeast)
IL-36 alpha/IL-1F6 Protein, Human, Recombinant (His)
Cat.No: TMPY-02818
Species: Human
Expression System: E. coli
IL-1F8 Protein, Human, Recombinant (His)
Cat.No: TMPY-02817
Species: Human
Expression System: E. coli
IL-1F8 Protein, Human, Recombinant
Cat.No: TMPY-02458
Species: Human
Expression System: E. coli
IL-1 alpha/IL-1A Protein, Cynomolgus, Recombinant (His)
Cat.No: TMPK-00920
Species: Cynomolgus
Expression System: HEK293 Cells
IL-25/IL17E Protein, Mouse, Recombinant (His)
Cat.No: TMPY-00855
Species: Mouse
Expression System: HEK293 Cells
IL-25/IL17E Protein, Human, Recombinant (hFc)
Cat.No: TMPY-00843
Species: Human
Expression System: HEK293 Cells
NEIL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-02798
Species: Human
Expression System: E. coli
IL-25/IL17E Protein, Canine, Recombinant (hFc)
Cat.No: TMPY-05563
Species: Canine
Expression System: HEK293 Cells
PPIL1 Protein, Human, Recombinant (His)
Cat.No: TMPY-03285
Species: Human
Expression System: E. coli
IL-25/IL17E Protein, Human, Recombinant (His)
Cat.No: TMPJ-00060
Species: Human
Expression System: HEK293 Cells
IL12A & IL12B Heterodimer Protein, Human, Recombinant (Flag & His)
Cat.No: TMPH-01518
Species: Human
Expression System: HEK293 Cells
IL-25/IL17E Protein, Rat, Recombinant (hFc)
Cat.No: TMPY-03204
Species: Rat
Expression System: HEK293 Cells
IL-1 alpha/IL1A Protein, Rhesus macaque, Recombinant (His & SUMO)
Cat.No: TMPH-02438
Species: Rhesus
Expression System: E. coli
IL12RB2 Protein, Human, Recombinant (His)
Cat.No: TMPH-01558
Species: Human
Expression System: P. pastoris (Yeast)
TAB2 Protein, Human, Recombinant (His & Myc)
Cat.No: TMPH-02194
Species: Human
Expression System: Baculovirus Insect Cells
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