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CD166/ALCAM Protein, Mouse, Recombinant (His & hFc)

CD166/ALCAM Protein, Mouse, Recombinant (His & hFc)

产品编号 TMPY-01031
别名: CD166, AI853494, MuSC, DM-GRASP, BEN, activated leukocyte cell adhesion molecule, SC1

Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

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CD166/ALCAM Protein, Mouse, Recombinant (His & hFc) Chemical Structure
CD166/ALCAM Protein, Mouse, Recombinant (His & hFc), CAS N/A
规格 价格/CNY 货期 数量
100 μg ¥ 3,820 5日内发货

CD166/ALCAM Protein, Mouse, Recombinant (His & hFc) 的其他形式现货产品:

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea Pluripotin CD166/ALCAM Protein, Human, Recombinant (His)
产品目录号及名称: CD166/ALCAM Protein, Mouse, Recombinant (His & hFc) (TMPY-01031)
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参考文献
产品描述 Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.
别名 CD166, AI853494, MuSC, DM-GRASP, BEN, activated leukocyte cell adhesion molecule, SC1
分子量 84.2 kDa (predicted)

存储

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6~12 month

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TargetMol Library Books参考文献

1. Swart GW. (2002) Activated leukocyte cell adhesion molecule (CD166/ALCAM): developmental and mechanistic aspects of cell clustering and cell migration. Eur J Cell Biol. 81(6): 313-21. 2. Fujiwara H,et al.(2003) Human blastocysts and endometrial epithelial cells express activated leukocyte cell adhesion molecule (ALCAM/CD166). J Clin Endocrinol Metab. 88(7): 3437-43. 3. Jezierska A,et al.(2006) ALCAM/CD166 protects breast cancer cells against apoptosis and autophagy. Med Sci Monit. 12(8): BR263-73. 4. Kahlert C,et al.(2009) Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse. Br J Cancer. 101(3): 457-64.

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Keywords

CD166/ALCAM Protein, Mouse, Recombinant (His & hFc) AI 853494 SC-1 CD166 AI853494 MuSC CD 166 AI-853494 DM-GRASP BEN activated leukocyte cell adhesion molecule CD-166 SC1 SC 1 Inhibitor inhibitor inhibit

 

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