Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Testolone 是一种有效的、非甾体的、具有口服活性的、选择性雄激素受体调节剂 (SARM),Ki 为 7 nM。它对雄激素受体的选择性比其他类固醇激素核受体高。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 257 | 待询 | ||
5 mg | ¥ 462 | 待询 | ||
10 mg | ¥ 687 | 待询 | ||
25 mg | ¥ 830 | 待询 | ||
50 mg | ¥ 1,407 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 462 | 待询 |
产品描述 | RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer. |
靶点活性 | Androgen receptor:7 nM |
体外活性 | RAD140 demonstrates excellent affinity for the androgen receptor (Ki = 7 nM) as well as good selectivity over other steroid hormone nuclear receptors. |
体内活性 | in vivo: The stability of RAD140 is high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats and monkeys. RAD140 is also neuroprotective using the rat kainate lesion model. RAD140 is shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate. |
别名 | Testolone, RAD140 |
分子量 | 393.82 |
分子式 | C20H16ClN5O2 |
CAS No. | 1182367-47-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5392 mL | 12.6962 mL | 25.3923 mL | 63.4808 mL |
5 mM | 0.5078 mL | 2.5392 mL | 5.0785 mL | 12.6962 mL | |
10 mM | 0.2539 mL | 1.2696 mL | 2.5392 mL | 6.3481 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vosilasarm 1182367-47-0 Endocrinology/Hormones Androgen Receptor oral androgen RAD 140 Inhibitor neuronal Testolone RAD140 neuroprotective inhibit RAD-140 inhibitor