Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lirequinil (Ro 41-3696) 是一种小分子 GABAA 受体激动剂,可用于研究神经系统疾病。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,120 | 现货 | ||
5 mg | ¥ 2,800 | 现货 | ||
10 mg | ¥ 4,160 | 现货 | ||
25 mg | ¥ 6,630 | 现货 | ||
50 mg | ¥ 8,850 | 现货 | ||
100 mg | ¥ 11,900 | 现货 | ||
500 mg | ¥ 24,300 | 现货 |
产品描述 | Lirequinil (Ro 41-3696) is a small molecule GABAA receptor agonist used to study neurological disorders. |
体内活性 | In a double-blind, six-way crossover study of the effects on psychomotor performance and memory of single doses of Ro 41-3696 (Lirequinil) (1, 3, 5, and 10 mg), a novel non-benzodiazepine partial agonist at the benzodiazepine receptor, zolpidem (10 mg) and placebo were compared after night-time administration to 12 healthy young male subjects. Psychomotor performance tests (tracking and attention as part of a standardized task battery) were conducted just before and at 1.5 and 8 h after drug intake. The memory test consisted of the recall of a list of 15 words at 8 h after drug intake which had been learned at 1.5 h after intake. At 1.5 h after drug intake 10 mg zolpidem induced markedly larger psychomotor effects than any dose of Ro 41-3696. The effects of 5 and 10 mg Ro 41-3696 and zolpidem were significantly greater than those of placebo (P < 0.05). The following morning, 8 h after drug intake, the slight residual effects of 5 and 10 mg Ro 41-3696 were statistically significantly greater than placebo, whereas zolpidem effects did not differ from placebo. The results of the memory test showed that learning as well as recall was most clearly impaired by zolpidem. An influence of Ro 41-3696 on these variables was not observed for doses up to 5 mg. In conclusion, Ro 41-3696 at all doses tested induced fewer effects on psychomotor performance and memory than 10 mg zolpidem at 1.5 h after intake. However, the effects of Ro 41-3696 appeared to be of longer duration. [2] |
别名 | RO413696, RO-413696, RO41-3696, RO 413696, Ro 41-3696, Ro-41-3696 |
分子量 | 448.94 |
分子式 | C26H25ClN2O3 |
CAS No. | 143943-73-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Lirequinil 143943-73-1 Membrane transporter/Ion channel Neuroscience GABA Receptor RO413696 RO-413696 RO41-3696 RO 413696 Ro 41-3696 Ro-41-3696 Inhibitor inhibitor inhibit