Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 980 | 35日内发货 | ||
5 mg | ¥ 1,690 | 35日内发货 | ||
10 mg | ¥ 2,900 | 35日内发货 | ||
50 mg | ¥ 12,000 | 35日内发货 |
产品描述 | L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively). |
靶点活性 | mGlu7:249 μM (EC50), mGlu4:0.13 μM (EC50), mGlu6:1.0 μM (EC50), mGlu8:0.29 μM (EC50) |
体内活性 | L-APB(5 to 30 μg; intrathecal injection) obviously enhances the paw withdrawal threshold in response to the application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. The maximal effect of L-APB appears within 45 min and gradually subsided in 120 min following intrathecal administration. Paw withdrawal threshold in response to the application of von Frey filaments before spinal nerve ligation is 22.6±2.4 g. The mechanical threshold decreases significantly (2.3±0.5 g, P<0.05) within 10 days after nerve ligation and remains stable for at least 8 weeks [2]. |
别名 | L-APB, L-AP 4 |
分子量 | 183.1 |
分子式 | C4H10NO5P |
CAS No. | 23052-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (273.07 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 5.4615 mL | 27.3075 mL | 54.615 mL | 136.5374 mL |
5 mM | 1.0923 mL | 5.4615 mL | 10.923 mL | 27.3075 mL | |
10 mM | 0.5461 mL | 2.7307 mL | 5.4615 mL | 13.6537 mL | |
20 mM | 0.2731 mL | 1.3654 mL | 2.7307 mL | 6.8269 mL | |
50 mM | 0.1092 mL | 0.5461 mL | 1.0923 mL | 2.7307 mL | |
100 mM | 0.0546 mL | 0.2731 mL | 0.5461 mL | 1.3654 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
L-AP4 23052-81-5 Neuroscience GluR L AP4 L-APB L-AP-4 L-AP 4 LAP4 Inhibitor inhibitor inhibit