Powder: -20°C for 3 years | In solvent: -80°C for 1 year
B355252 是苯氧基噻吩磺酰胺小分子,NGF 受体激动剂。它能增强 NGF 诱导的神经突生长。它可减轻 DNA 损伤、抑制 ROS 生成、降低 LDH 水平以及预防神经元凋亡,保护缺血性神经元免受神经元损失。它具有抗细胞凋亡作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,130 | 现货 | ||
5 mg | ¥ 3,200 | 现货 | ||
10 mg | ¥ 4,690 | 现货 | ||
25 mg | ¥ 7,420 | 待询 | ||
50 mg | ¥ 9,800 | 待询 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,980 | 现货 |
产品描述 | B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth. |
体外活性 | Method: HT22 cells were pretreated for 2 hours with various concentrations of B355252 (0.625-20 μM). This was followed by the addition of 300 μM CoCl2 and incubation at 37oC for 24 hours. At the end of this time, cell viability was determined by resazurin assay as described below. Result: From 0.625 to 5 μM, B355252 increased cell viability in a dose-dependent manner, protecting against CoCl2-induced hypoxia. Above 5 μM, B355252 became toxic to the cells and, synergistically with CoCl2, decreased cell viability. |
分子量 | 514.06 |
分子式 | C25H24ClN3O3S2 |
CAS No. | 1261576-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (48.63 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9453 mL | 9.7265 mL | 19.453 mL | 48.6325 mL |
5 mM | 0.3891 mL | 1.9453 mL | 3.8906 mL | 9.7265 mL | |
10 mM | 0.1945 mL | 0.9726 mL | 1.9453 mL | 4.8632 mL | |
20 mM | 0.0973 mL | 0.4863 mL | 0.9726 mL | 2.4316 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
B355252 1261576-81-1 Others neurite outgrowth ischemic neurons HT22 glutamate Inhibitor Apoptosis DNA damage inhibit NGF LDH level ROS production B 355252 Parkinson disease phenoxy thiophene sulfonamide B-355252 inhibitor