STAT

The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. There are 4 JAK proteins: JAK1, JAK2, JAK3 and TYK2. JAKs contains a FERM domain (approximately 400 residues), an SH2-related domain (approximately 100 residues), a kinase domain (approximately 250 residues) and a pseudokinase domain (approximately 300 residues). The kinase domain is vital for JAK activity, since it allows JAKs to phosphorylate (add phosphate groups to) proteins.

Cat. No.	Product Name	CAS No.	Purity
TN1775	Isocryptotanshinone 异隐丹参酮	22550-15-8	98%
TN1775	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative r...
TMA1743	Ergosterol peroxide 过氧麦角甾醇	2061-64-5	98%
TMA1743	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fox...
T74950	Antitumor agent-73 化合物 Antitumor agent-73	2812356-72-0	98%
T74950	Antitumor agent-73是一种Diosgenin衍生物，具有阻断STAT3信号传导和外源性激活Pdia3/ERp57的能力。该化合物对多种癌细胞表现出显著的抗肿瘤活性，其效力为Diosgenin的7.9至341.7倍。
T11449	Golotimod hydrochloride (229305-39-9 free base) 化合物 T11449	T11449	98%
T11449	Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis...
TN4489	Manassantin A 化合物 TN4489	88497-87-4	98%
TN4489	Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
T15234	ENMD-1198 化合物 T15234	864668-87-1	98%
T15234	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
TN4356	Jolkinolide A 化合物 TN4356	37905-07-0	98%
TN4356	Jolkinolide A has anti-tumor activity. It inhibited VEGF expression in A549 cells through the inhibition of the Akt-STAT3-mTOR signaling pathway, and directly in...
TN2775	2-Methoxystypandrone 化合物 TN2775	85122-21-0	98%
TN2775	2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-ÎºB signaling to limit the inflamm...
TN4604	Myricanone 化合物 TN4604	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4490	Manassantin B 化合物 TN4490	88497-88-5	98%
TN4490	Manassantin B is a potent inhibitor of NF-ÎºB activation by the suppression of transciptional activity of RelA/p65 subunit of NF-ÎºB. It also possesses anti-EBV ...
TN1985	Neoprzewaquinone A 甘西鼠尾新酮A	630057-39-5	98%
TN1985	Neoprzewaquinone A (NEO) 是 S. miltiorrhiza 的活性成分，通过靶向 PIM1 阻断 ROCK2/STAT3 通路来抑制乳腺癌细胞迁移并促进平滑肌松弛。
TP2222L	APTSTAT3-9R acetate 化合物APTSTAT3-9R acetate		98%
TP2222L	APTSTAT3-9R acetate 是一种特异性肽结合 STAT3，具有抗增殖和抗肿瘤活性。 APTSTAT3-9R acetate 并通过特异性阻断 STAT3 磷酸化来抑制 STAT3 活化和下游信号传导。
T4571	Balsalazide 巴柳氮	80573-04-2	98%
T4571	Balsalazide (Balsalazido) 可通过调节IL-6/STAT3通路起抑癌作用，可用于治疗炎症性肠病。
T71550	STAT3-IN-8 化合物 STAT3-IN-8	1041438-68-9	98%
T71550	STAT3-IN-8（即化合物H172）是一种高效的STAT3抑制剂，具备在癌症研究中应用的潜力。
T24838	Stafib-1 化合物Stafib-1	1688703-26-5	98%
T24838	Stafib-1 是一种特异性的 STAT5β 抑制剂，靶向 SH2 结构域，IC50 为 154 nM，Ki 为 44 nM。
T14330	Ascochlorin 化合物 T14330	26166-39-2	98%
T14330	Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, primarily exerts its anti-tumor properties by inhibiting the STAT3 signaling pathway. It induces apoptosis ...
T121011	TLC1566-0618 化合物TLC1566-0618	708218-62-6	98%
T121011	TLC1566-0618 显示抗肿瘤活性并靶向stat。
TN3541	Broussonin E 化合物 TN3541	90902-21-9	98%
TN3541	Broussonin E could suppress inflammation by modulating macrophages activation state via inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathwa...
T21267	HODHBt 3,4-二氢-3-羟基-4-OXO-1,2,3-苯并三嗪	28230-32-2	99.99%
T21267	HODHBt 是一种 STAT5-SUMO 蛋白-蛋白相互作用抑制剂。
TN1059	Ganoderic acid B 灵芝酸B	81907-61-1	99.95%
TN1059	Ganoderic acid B 是从灵芝中分离的一种三萜类天然产物。它是端粒酶抑制剂，抑制 Epstein-Barr 病毒抗原的活化。它是 HIV-1 蛋白酶抑制剂。