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Search Results for " β-galactosidase "

21

抑制剂 & 化合物

1

天然产物

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重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T73615	β-Galactosidase
	β-Galactosidase，即 β-半乳糖苷酶，是一种糖苷水解酶，可水解半乳糖与其有机部分之间形成的 β-糖苷键。在大肠杆菌中，lacZ 基因是 β-半乳糖苷酶的结构基因，可作为诱导系统lac 操纵子的一部分。β-Galactosidase 可以水解乳糖形成葡萄糖和半乳糖，进入糖酵解；也可以催化乳糖转半乳糖基化为异乳糖；异乳糖可以裂解成单糖。
T76134	α-Galactosidase
	α-Galactosidase(EC 3.2.1.22)，即 α-半乳糖苷酶，是一种糖苷水解酶，广泛存在于动植物和微生物中，常用于生化研究。α-Galactosidase 可以催化 α-1,6 连接的末端半乳糖残基的水解，包括低聚半乳糖、半乳甘露聚糖和半乳糖脂。催化许多分解代谢过程，包括糖蛋白、糖脂和多糖的裂解。
T19497	ONPG 2-硝基苯-beta-D-半乳糖苷,2-Nitrophenyl β-D-galactopyranoside	Others	Others
	ONPG (2-Nitrophenyl β-D-galactopyranoside) 是用作比色和分光光度计底物，可用作 β-半乳糖苷酶活性的检测。
T19075	X-GAL 5-溴-4-氯-3-吲哚半乳糖苷,BCIG	Others	Others
	X-GAL (BCIG) 是一种使用广泛的显色 β-半乳糖苷酶底物。其中β-半乳糖苷酶能够切割 X-GAL ，并可产生不溶性蓝色化合物。
T9750	Cetyldimethylethylammonium Bromide	Others	Others
	Cetyldimethylethylammonium Bromide 可用于诱导细胞外分泌 β-半乳糖苷酶。
T1699	resorufin galactopyranoside	Others	Others
	resorufin galactopyranoside 是β-半乳糖苷酶的荧光底物，在被β-半乳糖苷酶酶切后，荧光部分间苯二酚被释放，其荧光可用于定量β-半乳糖糖苷酶的活性。它的激发光为570，发射光为580nm。
T37450	SSK1	p38 MAPK	MAPK
	SSK1 是一种选择性杀死衰老细胞的化合物，是一种针对 β-galactosidase 的前体，可减轻机体炎症反应。SSK1 可激活衰老细胞中 p38 MAPK 和 MKK3/MKK6 的磷酸化水平，促使衰老细胞线粒体 DNA 损伤。
T5489	Tryptophan, N-indol-3-ylacetyl- (6CI) N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan	Glucosidase	Metabolism
	Tryptophan, N-indol-3-ylacetyl- (6CI) (Indole-3-acetyl-L-tryptophan) 参与调节生理和病理生理反应过程中生长素活性的调节机制。还可用于合成β-D-半乳糖苷酶和β-D-葡萄糖苷酶抑制剂。
T15082	DDAO	Others	Others
	DDAO 是有潜在用途的近红外红色荧光探针，其激发波长 (600-650 nm) 和长发射波长 (λem = 656 nm)可以调节。它可用于不同酶活性的检测，如 β-半乳糖苷酶，羧酸酯酶 2，硫酸酯酶，蛋白质磷酸酶 2A，人白蛋白和酯酶。
T81673	NIR-βgal-2
	NIR-βgal-2，一种针对β-半乳糖苷酶的近红外荧光探针，特点是具有高度的灵敏性，适用于乳腺癌中β-半乳糖苷酶的可视化研究。
T18993	Fluorescein di(β-D-galactopyranoside) FDG	Others	Others
	Fluorescein di(β-D-galactopyranoside) is a fluorogenic substrate for β-galactosidase (λem=535 nm, λex=485 nm).
T81258	Rose-β-D-Gal Salmon-Gal
	Rose-β-D-Gal为一种荧光染料及β-半乳糖苷酶的底物，反应后生成粉红色/品红色，适用于β-gal活性检测。
T81347	Purple-β-D-Gal
	Purple-β-D-Gal是一种用于检测β-galactosidase活性的底物。该化合物在细胞内被酶解，释放出吲哚基分子。这些分子在原位氧化并二聚成靛蓝，形成不溶于水的色素沉淀，从而实现显色反应。
T37330	Pyridindolol
	Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 1.Aoyagi, T., Kumagai, M., Ha...
T37569	4-Methylumbelliferyl-β-D-Galactoside
	4-Methylumbelliferyl-β-D-galactoside (MUG) is a fluorogenic substrate for β-galactosidase (β-gal).1Hydrolysis of MUG by β-gal releases the fluorescent moiety 4-MU, which displays a pH-dependent excitation maximum of 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively, and an emission maximum between 445-454 nm.2MUG has been used to detect β-gal activity in intact bacteria, yeast, and mammalian cells.1 1.Vidal-Aroca, F., Giannattasio, M., Brunelli, E., et al.One-step high-throughput assay...
T36835	(2R)-Glycerol-O-β-D-galactopyranoside
	(2R)-Glycerol-O-β-D-galactopyranoside is a substrate for β-galactosidase, the lactose repressor, the galactose-binding protein, and the β-methylgalactoside transport system. It also serves as a substrate for the third lac operon encoded enzyme, thiogalactoside transacetylase.
T38987	5-Fluorouridine 5'-O-β-D-galactopyranoside 5'-O-β-D-galactosyl-5-fluorouridine,5-Fluorouridine 5'-O-β-D-galactopyranoside
	5-Fluorouridine 5'-O-β-D-galactopyranoside, also known as 5'-O-β-D-galactosyl-5-fluorouridine, is a prodrug of 5-Fluorouridine. 5-Fluorouridine 5'-O-β-D-galactopyranoside can be enzymatically converted by β-D-galactosidase into 5-Fluorouridine, which is a highly effective antineoplastic agent.
T78452	X-GalNAc
	X-GalNAc是用作检测琼脂板上生长的细菌中克隆DNA插入片段的N-乙酰-β-半乳糖苷酶的显色底物。
T37843	Australine (hydrochloride)
	Australine is a pyrrolizidine alkaloid originally isolated fromC. australethat has enzyme inhibitory activities.1,2,3It is an inhibitor of glucoamylase (IC50= 5.8 μM) that also inhibits glucosidase I, sucrase, maltase, andA. nigerα-glucosidase (IC50s = 20, 28, 35, and 28 μM, respectively).2,3Australine is selective for these enzymes over glucosidase II, α- and β-mannosidase, and α- and β-galactosidase up to 500 μM, β-glucosidase, with only 5% inhibition at 66 μM, as well as isomaltase and trehal...
T36984	Cyclic di-IMP (sodium salt)
	Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p...
T37582	Ganglioside GM1 Mixture (ovine) (ammonium salt)
	Ganglioside GM1is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2It is found in a large variety of cells, including immune cells and neurons, and is enriched in lipid rafts in the cell membrane.3It associates with growth factor receptors, including TrkA, TrkB, and the GDNF receptor complex containing Ret and GFRα, and is required for TrkA expression on the cell surface. Ganglioside GM1interacts with other proteins to increase calcium i...

化合物

β-Galactosidase

Cat.No: T73615

α-Galactosidase

Cat.No: T76134

Cat.No: T19497

Synonym: 2-硝基苯-beta-D-半乳糖苷,2-Nitrophenyl β-D-galactopyranoside

Target: Others

Cat.No: T19075

Synonym: 5-溴-4-氯-3-吲哚半乳糖苷,BCIG

Target: Others

Cetyldimethylethylammonium Bromide

Cat.No: T9750

Target: Others

resorufin galactopyranoside

Cat.No: T1699

Target: Others

Cat.No: T37450

Target: p38 MAPK

Tryptophan, N-indol-3-ylacetyl- (6CI)

Cat.No: T5489

Synonym: N-(3-吲哚乙酰基)-L-色氨酸,N-(3-Indolylacetyl)-L-tryptophan,Indole-3-acetyl-L-tryptophan

Target: Glucosidase

Cat.No: T15082

Target: Others

Cat.No: T81673

Fluorescein di(β-D-galactopyranoside)

Cat.No: T18993

Synonym: FDG

Target: Others

Cat.No: T81258

Synonym: Salmon-Gal

Purple-β-D-Gal

Cat.No: T81347

Cat.No: T37330

4-Methylumbelliferyl-β-D-Galactoside

Cat.No: T37569

(2R)-Glycerol-O-β-D-galactopyranoside

Cat.No: T36835

5-Fluorouridine 5'-O-β-D-galactopyranoside

Cat.No: T38987

Synonym: 5'-O-β-D-galactosyl-5-fluorouridine,5-Fluorouridine 5'-O-β-D-galactopyranoside

Cat.No: T78452

Australine (hydrochloride)

Cat.No: T37843

Cyclic di-IMP (sodium salt)

Cat.No: T36984

Ganglioside GM1 Mixture (ovine) (ammonium salt)

Cat.No: T37582

Cat. No.	Product Name	Target	Signaling Pathways
T10941	D-Ribonolactone D-(+)-核糖酸-1,4-内酯,D-核糖内酯	Endogenous Metabolite; Antibacterial	Metabolism; Microbiology/Virology
	D-Ribonolactone 是一种大肠杆菌 β-半乳糖苷酶的抑制剂，Ki 为 26 mM。它也一种糖内酯。

天然产物

D-Ribonolactone

Cat.No: T10941

Synonym: D-(+)-核糖酸-1,4-内酯,D-核糖内酯

Target: Endogenous Metabolite, Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00728	Beta-galactosidase Protein, E. coli, Recombinant Beta-gal,Beta-galactosidase,lacZ,β-gal...	E. coli	E. coli
	β-galactosidase is an exoglycosidase which hydrolyzes the β-glycosidic bond formed between a galactose and its organic moiety. It may also cleave fucosides and arabinosides but with much lower efficiency. β-galactosides include carbohydrates containing galactose where the glycosidic bond lies above the galactose molecule. Substrates of different β-galactosidases include ganglioside GM1, lactosylceramides, lactose, and various glycoproteins. It is an essential enzyme in the human body. Deficienci...
TMPJ-00869	GLB1 Protein, Human, Recombinant (His) Lactase,Acid Beta-Galactosidase,Elastin Receptor 1,...	Human	HEK293 Cells
	β Galactosidase is a lysosomal β Galactosidase that hydrolyzes the terminal β Galactose from Ganglioside and Keratan sulfate. In lysosome, the mature β Galactosidase protein associates with Cathepsin A and Neuraminidase 1 to form the lysosomal multienzyme complex . An alternative splicing at the RNA level of β Galactosidase results a catalytically inactive β Galactosidase that plays an important role in vascular development. Defects of β-galactosidase (GLB1) are the cause of diseases like GM1-ga...
TMPY-01727	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) GLA/α-Galactosidase A Protein,galactosidase	Human	HEK293 Cells
	GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.8 kDa and the accession number is P06280.
TMPY-02857	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) galactosidase, alpha,Ags,galactosidase, α,...	Mouse	HEK293 Cells
	GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.6 kDa and the accession number is Q8BGZ6.
TMPH-00129	Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His)	Aspergillus niger	P. pastoris (Yeast)
	Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 48.7 kDa and the accession number is A2QEJ9.
TMPK-00944	ST3GAL4 Protein, Human, Recombinant (HA, His) STZSIAT4,ST-4,SIAT4,ST3GAL4,SAT3,CGS23,SIAT4C,Gal-NAc 6S,NAN...	Human	HEK293 Cells
	ST3GAL4 gene expression is altered in different cancer types, including cervical cancer. Several mRNA transcripts have been reported for this gene. ST3GAL4 encodes for β‑galactosidase α‑2,3‑sialyltransferase 4, involved in the biosynthesis of the tumour antigens sLe(x) and sulfo‑sLe(x).
TMPJ-01287	Sialidase-1 Protein, Human, Recombinant (His) NEU1,NANH,Lysosomal Sialidase,G9 Sialidase,Sialidase-1,N-Ace...	Human	HEK293 Cells
	Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosi...

重组蛋白

Beta-galactosidase Protein, E. coli, Recombinant

Cat.No: TMPJ-00728

Species: E. coli

Expression System: E. coli

GLB1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00869

Species: Human

Expression System: HEK293 Cells

GLA/alpha-Galactosidase A Protein, Human, Recombinant (His)

Cat.No: TMPY-01727

Species: Human

Expression System: HEK293 Cells

GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02857

Species: Mouse

Expression System: HEK293 Cells

Probable Alpha Galactosidase B Protein, Aspergillus niger, Recombinant (His)

Cat.No: TMPH-00129

Species: Aspergillus niger

Expression System: P. pastoris (Yeast)

ST3GAL4 Protein, Human, Recombinant (HA, His)

Cat.No: TMPK-00944

Species: Human

Expression System: HEK293 Cells

Sialidase-1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01287

Species: Human

Expression System: HEK293 Cells

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