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Search Results for " vulgaris "

26

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14369	AZD-0284	ROR	Metabolism
	AZD-0284 是核受体 (RORγ) 的选择性反向激动剂。它对呼吸道疾病及斑块型寻常型银屑病具有潜在的应用价值。
T5002	Methyl Aminolevulinate Hydrochloride 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride	Others	Others
	Methyl Aminolevulinate Hydrochloride (5-Aminolevulinic acid methyl ester) 是增敏剂，可用于光动力疗法。Methyl aminolevulinate 是一种前药，可代谢为原卟啉 IX。
T1466	Nadifloxacin OPC7251,那氟沙星	Antibacterial; Antibiotic	Microbiology/Virology
	Nadifloxacin (OPC7251) 是一种对粉刺有效的广谱氟喹诺酮类抗生素。
T3510	Olumacostat Glasaretil	Acetyl-CoA Carboxylase	Metabolism
	Olumacostat glasaretil 是乙酰辅酶A 羧化酶的有效抑制剂。
T7858	Ceftezole sodium Celoslin,Falomesin,头孢替唑钠,Alomen	Anti-infection; Antibacterial; Antibiotic; Glucosidase	Metabolism; Microbiology/Virology
	Ceftezole sodium (Falomesin) 是一种广谱 cephem 抗生素，具有抑制多种革兰氏阳性菌和革兰氏阴性菌活性。它是一种α-葡萄糖苷酶抑制剂，具有体内抗糖尿病活性。
T65816	Prolyl-4-hydroxylase Inhibitor 11	Others	Others
	Prolyl-4-hydroxylase Inhibitor 11 是一种新型脯氨酸4-羟化酶抑制剂，对普通小球藻(Chlorella vulgaris)氧化应激和 Cu(II)毒性的保护作用。
T24755	Salnacedin G-201,SCY,G-201,G201,SCY,G 201	Others	Others
	Salnacedin (G-201) 是一种小分子化合物，可用于治疗免疫系统疾病、皮肤和肌肉骨骼疾病，可用于研究寻常痤疮、皮炎和银屑病。
T76778	Risankizumab Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor	Immunology/Inflammation
	Risankizumab (BI 655066) 是一种人源化靶向 IL-23 p19 亚基的 IgG 单克隆抗体(Kd <10 pM)。 Risankizumab 能抑制人 IL-23 在小鼠脾细胞中诱导的 IL-17 产生，IC50 值为 2 pM。Risankizumab 可用于预防和治疗如寻常型银屑病、银屑病关节炎、广泛性脓疱型银屑病和红皮病型银屑病类的免疫性和炎症性疾病。
T21394	Sarecycline hydrochloride P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672
	Sarecycline, a novel and tetracycline-derived antibiotic, is being developed for use as an oral once daily antibiotic treatment for patients suffering from moderate to severe acne vulgaris. Sarecycline has anti-inflammatory activity and the potential for
T38021	Obafluorin
	Obafluorin is a β-lactone antibiotic that has been found in P. fluorescens.1 It is active against S. aureus, S. faecalis, K. pneumoniae, and P. vulgaris (MIC = 125 μg/ml for all). \|1. Pu, Y., Lowe, C., Sailer, M., et al. Synthesis, stability, and antimicrobial activity of (+)-obafluorin and related β-lactone antibiotics. J. Org. Chem. 59(13), 3642-3655 (1994).
T34511	Sandosaponin B
	Sandosaponin B is a olean-12-ene-type triterpene oligoglycoside isolated from kidney bean, the seed of Phaseolus vulgaris L.
T20836	Sandosaponin A
	Sandosaponin A, an olean-12-ene-type triterpene oligoglycoside, is isolated from kidney bean, the seed of Phaseolus vulgaris L.
T38333	Corynecin I
	Corynecin I is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It is active against Gram-positive and Gram-negative bacteria with MIC values of 5.2-83 μg/ml for S. sonnei, P. vulgaris, K. pneumoniae, and S. aureus among others.
T37837	2-Methylhexacosane
	2-Methylhexacosane is a saturated hydrocarbon and an insect pheromone.1,2It has been found in the cuticle ofM. dasystomusfemales, but not males, where it contributes to the mating behavior of males, as well as inD. melanogasterfemales where it modulates aggression of males towards females. 2-methylhexacosane has also been found in yellow jacket (V. vulgaris) trail extracts.3 1.Spikes, A.E., Pashen, M.A., Millar, J.G., et al.First contact pheromone identified for a longhorned beetle (Coleoptera: ...
T37731	TPU-0037A
	TPU-0037A is an antibiotic and a congener of lydicamycin . It inhibits the growth of Gram-positive bacteria, including methicillin-resistant S. aureus (MRSA), B. subtilis, and M. luteus (MICs = 1.56-12.5 μg/ml), but not Gram-negative E. coli, P. mirabilis, P. vulgaris, or P. aeruginosa strains (MICs = >50 μg/ml).
T36379	Halometasone
	Halometasone is a synthetic corticosteroid.1,2Formulations containing halometasone have been used in the treatment of psoriasis vulgaris and eczematous dermatoses. 1.de la Brassine, M., Kint, A., Lachapelle, J.M., et al.Halomethasone (C 48.401-Ba) for the topical treatment of common dermatosesJ. Int. Med. Res.12(5)307-309(1984) 2.Zhu, J.-W., Wu, X.-J., Lu, Z.-F., et al.Role of VEGF receptors in normal and psoriatic human keratinocytes: Evidence from irradiation with different UV sourcesPLoS One8...
T73047	Urease-IN-5
	Urease-IN-5, 作为一种尿素酶抑制剂，具有1.473 µM的IC50值。该化合物在细胞毒性方面表现较低，并对普通变形杆菌展现出17.78 µg/mL的IC50值的抑制活性。
T38334	Corynecin III
	Corynecin III is a chloramphenicol-like antibiotic originally isolated from Corynebacterium. It inhibits the growth of Gram-positive and Gram-negative bacteria, including S. faecalis, S. aureus, B. subtilis, E. coli, P. aeruginosa, P. vulgaris, S. sonnei, S. typhosa, and K. pneumoniae (MICs = 2.6-83 μg/ml).
T37263	14-methyl Pentadecanoic Acid methyl ester
	14-methyl Pentadecanoic acid methyl ester is a methylated fatty acid methyl ester that has been found in S. zeai sea sponges as the fatty acyl component of zeamide, A. indica leaf extract, and C. vulgaris and H. pluvialis microalgae. It is a major component of the vancomycin-induced biofilm produced by vancomycin-resistant S. aureus (VRSA). 14-methyl Pentadecanoic acid methyl ester has been used as a standard for the quantification of 14-methyl pentadecanoic acid in various foods by GC-MS.
T73046	Urease-IN-4
	Urease-IN-4是一种尿素酶 (urease) 抑制剂，具有1.64 µM的IC50值。此化合物对细胞毒性低，能有效抑制普通变形杆菌，其IC50值为15.27 µg/mL。
T35607	10'-Desmethoxystreptonigrin
	10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively). 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and tenipo...
T37490	11(R)-HETE
	11(R)-HETE is biosynthesized by 11(R)-LOs of the sea urchin, S. purpuratus, and the fresh water hydra, H. vulgaris. The biological activity of 11(R)-HETE relates to oocyte maturation and tentacle regeneration, respectively, in these two species. 11(R)-HETE is also produced when aspirin-treated recombinant COX-2 is incubated with arachidonic acid. Stereochemical assignment of the (R) enantiomer is based on comparison of chiral HPLC retention times to published results.
T41322	Dimethomorph
	Dimethomorph 是一种吗啉类杀菌剂，属于甾醇生物合成抑制剂类杀菌剂，可抑制真菌细胞壁的形成。Dimethomorph 抑制了oomycete fungi，P. citrophthora，P. parasitica，P. capsici，和P. infestans 的菌丝生长 (EC50=0.14 μg/mL，0.38 μg/mL，<0.1 μg/mL 和 0.16-0.3 μg/mL)，但是对绿藻物种C. vulgaris 和S. obliquus 的活性较低 (EC50=47.46 μg/mL 和 44.87 μg/mL)。在 MDA-kb2 人乳腺癌细胞的报告基因分析中，Dimethomorph 抑制雄激素受体 (AR) 的活性，而在酵母抗雄激素筛选中不起作用 (IC20=0.263 μM 和 38.5 μM)。
T37692	Piericidin B
	Piericidin B is a bacterial metabolite that has been found inS. mobaraensisand has insecticidal and antimicrobial activities.1,2,3It inhibits NADH oxidase activity in isolated bovine heart mitochondria and inhibits respiration in isolated rat liver mitochondria and isolated cockroach (P. americana) muscle mitochondria.2,3Topical application of piericidin B (4 μg/insect) induces mortality in 87.5% of houseflies (M. domestica).1It induces 93.3, 100, and 100% mortality in rice stem borer (C. simple...
T36537	Nitrofurantoin-13C3 Nitrofurantoin-13C3
	Nitrofurantoin-13C3is intended for use as an internal standard for the quantification of nitrofurantoin by GC- or LC-MS. Nitrofurantoin is a nitrofuran antibiotic.1In vivo, nitrofurantoin (25-100 mg/kg) reducesE. colireplication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates ofP. mirabilis. Nitrofurantoin also prevents alkalization of urine, as well as ca...
T36021	Flumequine-13C3 Flumequine-13C3
	Flumequine-13C3is intended for use as an internal standard for the quantification of flumequine by GC- or LC-MS. Flumequine is a fluoroquinolone antibiotic.1It is active againstS. aureus, S. pyogenes, B. subtilis, E. coli, P. aeruginosa, S. faecalis, andK. pneumoniae(MICs = 1-100 μg/ml). Flumequine is also active against field isolates of B. hyodysenteriae (MICs = 6.25-200 μg/ml).2It inhibits DNA gyrase, disrupting supercoiling of bacterial DNA to block transcription and replication.3In vivo, fl...

化合物

Cat.No: T14369

Target: ROR

Methyl Aminolevulinate Hydrochloride

Cat.No: T5002

Synonym: 5-Aminolevulinic acid methyl ester,Methyl δ-aminolevulinate hydrochloride,5-氨基酮戊酸甲酯盐酸盐,Methyl 5-aminolevulinate Hydrochloride,Aminolevulinic acid methyl ester Hydrochloride

Target: Others

Cat.No: T1466

Synonym: OPC7251,那氟沙星

Target: Antibacterial, Antibiotic

Olumacostat Glasaretil

Cat.No: T3510

Target: Acetyl-CoA Carboxylase

Ceftezole sodium

Cat.No: T7858

Synonym: Celoslin,Falomesin,头孢替唑钠,Alomen

Target: Anti-infection, Antibacterial, Antibiotic, Glucosidase

Prolyl-4-hydroxylase Inhibitor 11

Cat.No: T65816

Target: Others

Cat.No: T24755

Synonym: G-201,SCY,G-201,G201,SCY,G 201

Target: Others

Cat.No: T76778

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Target: IL Receptor

Sarecycline hydrochloride

Cat.No: T21394

Synonym: P005672,P-005672,WC-3035,WC 3035,Sarecycline HCl,WC3035,P 005672

Cat.No: T38021

Cat.No: T34511

Cat.No: T20836

Cat.No: T38333

2-Methylhexacosane

Cat.No: T37837

Cat.No: T37731

Cat.No: T36379

Cat.No: T73047

Cat.No: T38334

14-methyl Pentadecanoic Acid methyl ester

Cat.No: T37263

Cat.No: T73046

10'-Desmethoxystreptonigrin

Cat.No: T35607

Cat.No: T37490

Cat.No: T41322

Cat.No: T37692

Nitrofurantoin-13C3

Cat.No: T36537

Synonym: Nitrofurantoin-13C3

Flumequine-13C3

Cat.No: T36021

Synonym: Flumequine-13C3

Cat. No.	Product Name	Target	Signaling Pathways
TN7249	Nor-rubrofusarin gentiobioside
	Nor-rubrofusarin gentiobioside 是从豆科植物决明子中发现的天然产物。
TQ0192	Senecionine Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin	Others	Others
	Senecionine (Senecionin) 是一种吡咯里西啶生物碱，从Senecio vulgaris 中分离得到，它对动物和人类有毒性。
TN1127	Salviaflaside	Antioxidant	oxidation-reduction
	Salviaflaside 是夏枯草的主要生物活性成分，具有抗氧化活性。
T2A2524	2-Hydroxy-4-methoxybenzaldehyde 4-甲氧基水杨醛,4-Methoxysalicylaldehyde,2-羟基-4-甲氧基苯甲醛	Tyrosinase; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	2-Hydroxy-4-methoxybenzaldehyde (4-Methoxysalicylaldehyde) 是一种来自三种东非药用植物，Mondia whitei、Rhus vulgaris Meikle 和Sclerocarya caffra Sond 的酪氨酸酶抑制剂。它是香兰素的异构体，可用于合成尿苷M7。
T21262	Phaseollidin
	Phaseollidin, an antimicrobial phytoalexin, is produced by Phaseolus vulgaris (French bean).
T21261	Phaseolin
	Phaseolin, a protein from red kidney bean (Phaseolus vulgaris L.), plays a pivotal role in hypersensitivity induction.
T73874	Kievitone
	Kievitone 是一种异黄酮，是可以从Rhizoctonia solani Kühn 感染Phaseolus vulgaris L.的下胚轴中分离出来。Kievitone 具有抗真菌活性和抗肿瘤活性。
TN1729	Hellebrigenol	Others	Others
	Hellebrigenol 是从越南蟾蜍毒液中提取的丁二烯内酯，具有抗肿瘤活性。
T81122	Soyasaponin Af Acetyl-soyasaponin A2
	Soyasaponin Af (Acetyl-soyasaponin A2)，从黑豆种皮中提取的一种皂苷，具有生物活性。

天然产物

Nor-rubrofusarin gentiobioside

Cat.No: TN7249

Cat.No: TQ0192

Synonym: Aureine,Senecionan-11,16-dione, 12-hydroxy-,千里光宁,Senecionin

Target: Others

Cat.No: TN1127

Target: Antioxidant

2-Hydroxy-4-methoxybenzaldehyde

Cat.No: T2A2524

Synonym: 4-甲氧基水杨醛,4-Methoxysalicylaldehyde,2-羟基-4-甲氧基苯甲醛

Target: Tyrosinase, Antibacterial

Cat.No: T21262

Cat.No: T21261

Cat.No: T73874

Cat.No: TN1729

Target: Others

Cat.No: T81122

Synonym: Acetyl-soyasaponin A2

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