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Search Results for " voltage-sensitive "

21

抑制剂 & 化合物

2

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1198	Tetracaine hydrochloride 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl	Calcium Channel; Sodium Channel	Membrane transporter/Ion channel; Metabolism
	Tetracaine hydrochloride (Amethocalne HCl) 是一种钙通道蛋白抑制剂，可阻断肌浆网中 Ca2+的电压敏感释放。它主要用作眼科的止痒剂和局部用药，可用于表面和脊髓麻醉。
T11979	McN5691 RWJ26240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	McN5691 is a voltage sensitive calcium channel blocker.
T18974	DiBAC4(3)	Others	Others
	DiBAC4(3) 是电压敏感的荧光染料 (λex=490 nm，λem=505 nm)。
T12015	Methyl homoveratrate	Others	Others
	Methyl homoveratrate 是血浆、尿液和粪便提取物中 McN5691 的代谢物，是电压依赖性钙通道阻滞剂。
T16448	PD173212	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	PD 173212是一种阻断 N-型电压敏感性钙通道 (N-type voltage sensitive calcium channel, Cav2.2)的阻滞剂。PD173212的腹腔注射给药(0.0017-1.7 μmol/kg)显著降低了2,4-二硝基苯磺酸(DNBS)诱导结肠炎小鼠的内脏超敏反应。
T37688	Cyfluthrin	Reactive Oxygen Species; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB
	Cyfluthrin 属于 II 型拟除虫菊酯，对多种昆虫都有杀灭效果。Cyfluthrin 是Nav1.8钠通道调节剂。它可应用于农业、兽医、杀虫剂、拟除虫菊酯和贮存产品等领域。
T23280	Ruthenium Red 钌红,Ammoniated ruthenium oxychloride	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ruthenium Red (Ammoniated ruthenium oxychloride) 是一种 L 型钙电流 (ICa) 阻断剂，是一种聚阳离子染料，广泛用于电子显微镜 (EM) 下细胞、组织和营养细菌的观察。它能与磷脂和脂肪酸反应强烈，并与酸性粘多糖结合。
T6474	Divalproex Sodium Valproate semisodium,Epival,双丙戊酸钠	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶，其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成，具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
T18973	Di-8-ANEPPS	Others	Others
	Di-8-ANEPPS, a voltage-sensitive dye, demonstrates shifts in both its fluorescence excitation and emission spectra in response to changes in membrane potential (Vm).
T80458	ω-Conotoxin CVIA	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Conotoxin CVIA 为含27个氨基酸的神经肽毒素，作用为阻断电压敏感的钙通道（voltage sensitive calcium channels）。
T28227	Oe-9000 Oe 9000
	Oe-9000 is a blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents as well as slowly activating and inactivating tetrodotoxin-resistant (TTX-R) Na(+) currents at
T61145	Topiramate lithium
	Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3]
T30078	ANNINE-6plus
	ANNINE-6plus is a water soluble voltage sensitive dye (also called potentiometric dyes). This compound was developed at the Max Planck Institute for Biochemistry in Germany. It is used to optically measure the changes in transmembrane voltage of excitable
T80161	ω-Conotoxin SO3	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	ω-Conotoxin SO3为N型电压敏感钙通道的特异性阻断剂，源自C. striatus毒液，具备镇痛功能。
T80851	VSTx-3 Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F
	VSTx-3是KV通道阻断剂，同时也是TTX敏感钠通道尤其是NaV1.8通道的有效阻断剂。具体而言，其对hNaV1.3通道的IC50为0.19 μM，对hNaV1.7通道的IC50为0.43 μM，对hNaV1.8通道的IC50为0.77 μM。
T24692	QAQ dichloride
	QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and ...
T80189	Hainantoxin-IV HNTX-IV	Sodium Channel	Membrane transporter/Ion channel
	Hainantoxin-IV是针对河豚毒素敏感(TTX-S)电压门控钠通道的特异性拮抗剂。该化合物以His28和Lys32为主要残基与靶标结合，并采用了抑制剂胱氨酸结基序。
T80495	mHuwentoxin-IV	Sodium Channel	Membrane transporter/Ion channel
	mHuwentoxin-IV是一种经天然修饰的Huwentoxin-IV。该化合物针对背根神经节中河豚毒素敏感(TTX-S)电压门控钠通道(sodium channels)表现出抑制作用，IC50值为54.16 nM。mHuwentoxin-IV对这些钠通道的抑制作用并不会因强去极化电压而逆转。
T80426	Jingzhaotoxin-IX	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-IX是由35个氨基酸残基组成的C端酰胺化神经毒素。该化合物既抑制电压门控钠通道（包括河豚毒素抗性和河豚毒素敏感亚型）又抑制Kv2.1通道，但对延迟整流钾通道Kv1.1、1.2和1.3无效。
T82567	Di-4-ANEPPS
	Di-4-ANEPPS为膜电位电压敏感染料，时间分辨率达1 ms优于，并能够呈现每100 mV荧光变化高至10%。常用于描绘心脏电活动图，对兔离体心脏模型的自发心率和心室冲动传导显示出显著直接不可逆影响。
T82546	DiSBAC10
	DiSBAC10是一种电压敏感荧光探针，用于FRET检测中研究细胞膜的电活动。在静息极化的细胞中，DiSBAC10位于膜的外leaflet，从激发的荧光素标记蛋白那里接收光子，并以更高的波长重新发射光子。当细胞去极化时，DiSBAC10迅速转移到膜的内leaflet，从而增加了荧光团之间的距离并减少FRET信号。

化合物

Tetracaine hydrochloride

Cat.No: T1198

Synonym: 盐酸丁卡因,Amethocaine hydrochloride,Amethocalne HCl,Tetracaine HCl

Target: Calcium Channel, Sodium Channel

Cat.No: T11979

Synonym: RWJ26240

Target: Calcium Channel

Cat.No: T18974

Target: Others

Methyl homoveratrate

Cat.No: T12015

Target: Others

Cat.No: T16448

Target: Calcium Channel

Cat.No: T37688

Target: Reactive Oxygen Species, Sodium Channel

Cat.No: T23280

Synonym: 钌红,Ammoniated ruthenium oxychloride

Target: Calcium Channel

Divalproex Sodium

Cat.No: T6474

Synonym: Valproate semisodium,Epival,双丙戊酸钠

Target: HDAC

Cat.No: T18973

Target: Others

ω-Conotoxin CVIA

Cat.No: T80458

Target: Calcium Channel

Cat.No: T28227

Synonym: Oe 9000

Topiramate lithium

Cat.No: T61145

Cat.No: T30078

ω-Conotoxin SO3

Cat.No: T80161

Target: Calcium Channel

Cat.No: T80851

Synonym: Kappa-TRTX-Gr4a,κ-Theraphotoxin-Gr4a,Voltage sensor toxin 3,Peptide F

Cat.No: T24692

Cat.No: T80189

Synonym: HNTX-IV

Target: Sodium Channel

Cat.No: T80495

Target: Sodium Channel

Jingzhaotoxin-IX

Cat.No: T80426

Target: Sodium Channel

Cat.No: T82567

Cat.No: T82546

Cat. No.	Product Name	Target	Signaling Pathways
T10609	Brevetoxin-3 PbTx-3	Others	Others
	Brevetoxin-3 (PbTx-3) is a potent allosteric voltage-gated Na+ channel activator. Brevetoxin-3 has a high affinity to site 5 of the voltage-sensitive Na+ channels, inhibits the inactivation of Na+ channels.
TN4183	Hardwickiic acid (-)-Hardwikiic acid	Sodium Channel	Membrane transporter/Ion channel
	Hardwickiic acid ((-)-Hardwikiic acid) 是一种从Pulicaria gnaphalodes 中提取的天然化合物，是一种抗伤害性感受作用化合物。Hardwickiic acid 能阻断河豚毒素敏感的电压依赖性钠通道 (sodium channels)。Hardwickiic acid 具有抗炎和杀虫活性。

天然产物

Cat.No: T10609

Synonym: PbTx-3

Target: Others

Hardwickiic acid

Cat.No: TN4183

Synonym: (-)-Hardwikiic acid

Target: Sodium Channel

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