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14

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T26319	Vincanol Vincanolum
	Vincanol is a potent voltage-gated Na+ channels blocker.
T69072	Brovincamine
	Brovincamine also known as brovincamine fumarate (BV, Sabromin) was used in Japan mainly as an improver of cerebral circulation and metabolism, and also as an inhibitor of the aggregation of platelets through the cyclic AMP pathway in patients with normal tension glaucoma. Brovincamine exerts its action via calcium channels blockade. Brovincamine is also a vasodilator.
T68674	Vincapusine
	Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.
T37406	Apovincaminic acid hydrochloride salt
	Apovincaminic acid hydrochloride salt, the primary active metabolite of Vinpocetine (VP), is orally active and has the ability to penetrate the brain. It demonstrates a neuroprotective mechanism of action [1][2].
T35055	Vincamajine O-Deacetylvincamedine
	Vincamajine is a biochemical.
T125260	19-Hydroxypseudovincadifformine
	19-Hydroxypseudovincadifformine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125260。
T40620	Vinleurosine sulfate
	Vinleurosine sulfate, extracted from Vinca rosea Linn, is a potent antineoplastic indole alkaloid along with three others.
T7594	Vinflunine
	Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
T29434	4-Desacetylvinblastine hydrazide DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide
	Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent.
T6722	Vinflunine Tartrate	Microtubule Associated	Cytoskeletal Signaling
	Vinflunine Tartrate 是一种独特的新型长春花生物碱，具有抑制有丝分裂和微管蛋白相互作用活性的特性。
T37037	Vinflunine ditartrate
	Vinflunine ditartrate, a fluorinated microtubule inhibitor and member of the Vinca alkaloids family, exhibits anti-angiogenic, vascular-disrupting, and anti-metastatic properties. It presents a potential avenue for studying transitional cell carcinoma of the urothelial tract, non-small cell lung cancer, and breast carcinoma[1][2].
T69139	Thalicarpine
	Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent.
T69003	E7974
	E7974 is an analog of the sponge-derived anti-microtubule tripeptide hemiasterlin with antimitotic and potential antineoplastic activities. Hemiasterlin analog E7974 binds to the Vinca domain on tubulin, resulting in inhibition of tubulin polymerization and microtubule assembly; depolymerization of exsiting microtubules; inhibition of mitosis; and inhibition of cellular proliferation. This agent may have more affinity for the beta-3 tubulin isotype. Check for active clinical trials or closed cli...
T68249	IRC-083927 HCl
	IRC-083927 HCl is novel and potent microtubule inhibitor with potential anticancer activity. IRC-083927 inhibits the tubulin polymerization by a binding to the colchicine site. IRC-083927 inhibits in vitro cell growth of human cancer cell lines in the low nanomolar range. More interesting, it remains highly active against cell lines resistant to microtubule-interacting agents (taxanes, Vinca alkaloids, or epothilones). Chronic oral treatment with IRC-083927 (5 mg/kg) inhibits the growth of two h...

化合物

Cat.No: T26319

Synonym: Vincanolum

Cat.No: T69072

Cat.No: T68674

Apovincaminic acid hydrochloride salt

Cat.No: T37406

Cat.No: T35055

Synonym: O-Deacetylvincamedine

19-Hydroxypseudovincadifformine

Cat.No: T125260

Vinleurosine sulfate

Cat.No: T40620

Cat.No: T7594

4-Desacetylvinblastine hydrazide

Cat.No: T29434

Synonym: DAVLBH,Deacetylvinblastine hydrazide,Desacetylvinblastine hydrazide

Vinflunine Tartrate

Cat.No: T6722

Target: Microtubule Associated

Vinflunine ditartrate

Cat.No: T37037

Cat.No: T69139

Cat.No: T69003

Cat.No: T68249

Cat. No.	Product Name	Target	Signaling Pathways
T2773	Vindoline 文朵灵,文多灵	Microtubule Associated	Cytoskeletal Signaling
	Vindoline 是从长春花叶片中提取的一种生物碱，通过抑制微管组装而表现出抗有丝分裂活性。
T1286	Vincamine Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱，可作为外周血管扩张剂，对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态，对 2 型糖尿病具有研究潜力。它是GPR40激动剂，通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。
T21047	Apovincamine cis-Apovincamine
	Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.
TN2642	16,17-Dihydroapovincamine	Others	Others
	16,17-Dihydroapovincamine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2642，CAS号为 57130-30-0。
TN2620	14,15-Didehydrovincamenine	Others	Others
	14,15-Didehydrovincamenine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2620，CAS号为 112219-48-4。
TN2649	16-O-Methyl-14,15-didehydroisovincanol	Others	Others
	16-O-Methyl-14,15-didehydroisovincanol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2649，CAS号为 112237-71-5。
T2149	Vinburnine Eburnalritardo,L-Eburnamonine,长春布宁,Vincamone,(-)-Eburnamonine,(-)-Vincamone	Others; Drug Metabolite	Metabolism; Others
	Vinburnine (Eburnalritardo) 是一种长春花生物碱，是长春胺的代谢物和是血管扩张剂。
T0190	Vinorelbine 长春瑞宾,KW-2307 base	Microtubule Associated	Cytoskeletal Signaling
	Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成，导致中期肿瘤细胞生长停滞。
T6213	Vinorelbine ditartrate Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	Vinorelbine ditartrate (KW-2307)是一种抗有丝分裂剂，能够抑制 Hela 细胞的增殖，IC50值为 1.25 nM。
T22455	Vindesine sulfate DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS	Others	Others
	Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱，它是长春碱的合成衍生物，与有丝分裂纺锤体的微管蛋白结合，导致微管结晶和有丝分裂停滞或细胞死亡。
T19911	Rescinnamine Anaprel,Apoterin S,Apoterin
	Rescinnamine is an inhibitor of angiotensin-converting enzyme. It also is a vinca alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. It used as an antihypertensive drug.
T81976	Kopsinine
	Kopsinine，一种二氢吲哚生物碱，来源于长春花提取。
T82241	Halichondrin B
	Halichondrin B，源自海绵 Halichondria okadai，为非竞争性Vinca-alkaloid 微管蛋白结合抑制剂，微管蛋白聚合 IC50 值为1.2-1.4 μM，表现出抗肿瘤活性。

天然产物

Cat.No: T2773

Synonym: 文朵灵,文多灵

Target: Microtubule Associated

Cat.No: T1286

Synonym: Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval

Target: GPR, Others

Cat.No: T21047

Synonym: cis-Apovincamine

16,17-Dihydroapovincamine

Cat.No: TN2642

Target: Others

14,15-Didehydrovincamenine

Cat.No: TN2620

Target: Others

16-O-Methyl-14,15-didehydroisovincanol

Cat.No: TN2649

Target: Others

Cat.No: T2149

Synonym: Eburnalritardo,L-Eburnamonine,长春布宁,Vincamone,(-)-Eburnamonine,(-)-Vincamone

Target: Others, Drug Metabolite

Cat.No: T0190

Synonym: 长春瑞宾,KW-2307 base

Target: Microtubule Associated

Vinorelbine ditartrate

Cat.No: T6213

Synonym: Vinorelbine Tartrate,Nor-5'-anhydrovinblastine ditartrate,KW-2307,Navelbine tartrate,长春瑞滨酒石酸盐,酒石酸长春瑞滨

Target: Microtubule Associated, Autophagy

Vindesine sulfate

Cat.No: T22455

Synonym: DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS

Target: Others

Cat.No: T19911

Synonym: Anaprel,Apoterin S,Apoterin

Cat.No: T81976

Cat.No: T82241

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