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Cat. No. | Product Name | Target | Signaling Pathways |
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T80929 |
Trypanothione
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Trypanothione是锥虫中发现的双谷胱甘肽衍生物,具有抵御氧化压力的保护功能。 | |||
T74932 | Trypanothione synthetase-IN-1 | ||
Trypanothione synthetase-IN-1 (Compound 1) 为一竞争性婴儿利什曼虫锥体胱甘肽合成酶(TryS)抑制剂,以三胺亚精胺为多胺S时,IC50值为14.8 μM。 | |||
T74933 | Trypanothione synthetase-IN-2 | ||
Trypanothione synthetase-IN-2 (Compound 3) 为竞争性婴儿利什曼虫锥虫胱甘肽合成酶 (TryS) 抑制剂,以三胺亚精胺作为多胺S时,IC50 值为5.4 μM。 | |||
T64056 | Trypanothione synthetase-IN-4 | ||
Trypanothione synthetase-IN-4 是一个 L. infantumTryS 抑制剂,其活性依赖于多胺底物的浓度。Trypanothione synthetase-IN-4 表现出较强的抗 leishmanicidal 效果 (EC50: 0.6 μM,SI (选择性指数): 35)。Trypanothione synthetase-IN-4 能够用于研究利什曼病。 | |||
T74934 | Trypanothione synthetase-IN-3 | ||
Trypanothione synthetase-IN-3是一种针对Trypanothione synthetase (TryS)的非竞争性混合双曲线抑制剂,其Ki值为0.8 μM。该化合物主要用于研究寄生虫,例如L. infantum。 | |||
T10339 |
Antitrypanosomal agent 1
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Parasite | Microbiology/Virology |
Antitrypanosomal agent 1 是一种有效的选择性锥虫硫酮还原酶抑制剂,IC50为 3.3 μM。它抑制谷胱甘肽还原酶,IC50为 64.8 μM,抑制布氏锥虫,EC50为 1 μM。 | |||
T68828 |
Chinifur
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Chinifur is a selective inhibitor and subversive substrate" for Trypanosoma congolense trypanothione reductase" | |||
T79390 |
Antileishmanial agent-23
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Parasite | Microbiology/Virology |
Antileishmanial agent-23 (compound G1/9) 作为一种选择性trypanothione reductase (TR)抑制剂效力显著,展现了2.24 ± 0.52 μM的IC50值。该化合物有效抑制了利什曼原虫、克氏锥虫和布氏锥虫的生长。 | |||
T38372 |
2-Fluoro-4-iodo benzonitrile
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2-Fluoro-4-iodo benzonitrile is a building block.1,2It has been used in the synthesis ofL. infantumtrypanothione reductase (Li-TryR) dimerization and oxidoreductase activity inhibitors.12-Fluoro-4-iodo benzonitrile has also been used in the synthesis of transient receptor potential ankyrin 1 (TRPA1) antagonists.2 1.Revuelto, A., Ruiz-Santaquiteria, M., de Lucio, H., et al.Pyrrolopyrimidine vs imidazole-phenyl-thiazole scaffolds in nonpeptidic dimerization inhibitors of Leishmania infantum trypan... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN1016 |
Kukoamine A
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NF-κB; Lipoxygenase; DNA/RNA Synthesis; Parasite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology; NF-κB |
Kukoamine A 是一种天然的精胺衍生物,具有抗癌、抗高血压、细胞保护、抗氧化和抗炎活性。它是锥虫硫磷还原酶抑制剂,Ki 值为 1.8 μM。 | |||
T36448 |
(E)-Ajoene
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(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fungi (MICs = 15-50 μg/ml).1(E)-Ajoene inhibits proliferation of a variety of cancer cells, including MDA-MB-231 breast, HeLa cervical, and WHCO1 esophageal cancer cells (IC50s = 18.6, 61, and 39.2 μM, respectively).2It also inhibits human glutathione reductase andT. cruzitrypanoth... |