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Cat. No.	Product Name	Target	Signaling Pathways
T19080	DOPE 1,2-二油酰-SN-甘油-3-磷酰乙醇胺	Others	Others
	DOPE (DOPE) 是一种阳离子脂质体的中性辅助脂质 (helper lipid)，能够与阳离子磷脂结合，增强裸 siRNA 的转染效率。
T11086	DOTAP chloride (2,3-二油氧基丙基)三甲基氯化铵,1,2-Dioleoyl-3-trimethylammonium-propane chloride	Others	Others
	DOTAP chloride (1,2-Dioleoyl-3-trimethylammonium-propane chloride) 是高效的阳离子脂质，可以在不使用辅助脂质的情况下，作用于瞬时或者稳定转染 DNA (质粒、bacmids) 和修饰核酸 (反义寡核苷酸)。
T12598	Pz-1	VEGFR; c-RET	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Pz-1 是 VEGFR2 和 RET 酪氨酸激酶的抑制剂，可阻断 RET 刺激生长所需的血液供应。
T8902	DOTMA Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium	Others	Others
	DOTMA (N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium) 作为 tetra-methylated DOTA 类似物，是一种阳离子脂类，被用作基因治疗的非病毒载体。它已被用作脂质体的成分，可用于封装 siRNA、microRNA 和寡核苷酸，并用于体外基因转染。在体外和体内均表现出良好的基因转染效果。DOTMA 诱导脂质体上的正电荷，从而促进脂质体与细胞膜的有效相互作用。
TP2505L	LAH4 acetate KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial	Microbiology/Virology
	LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构，能够与DNA 络合，与细胞表面膜结合后被包裹在核内体中，随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
T32780	Lipofectin
	Lipofectin is used to promote the transfection of plasmid vectors in vitro and in vivo.
T10823	trans-Pralsetinib cis-Pralsetinib,cis-BLU-667	c-RET	Apoptosis; Tyrosine Kinase/Adaptors
	trans-Pralsetinib (trans-BLU-667) is an inhibitor of rearranged during transfection (RET).
T39313	KALA
	KALA, an amphiphilic peptide, adopts an α-helical conformation under physiological pH conditions. It functions as a fusogenic peptide, modifying the liposomal membrane that encapsulates plasmid DNA, thereby facilitating liver targeting and DNA transfection through galactose receptors.
T1656L	Vandetanib Fumarate HSDB 8198,Zactima,Caprelsa,ZD 6474,Vandetanib
	Vandetanib Fumarate is an orally available tyrosine kinase inhibitor. Vandetanib Fumarate works by blocking RET (REarranged during Transfection), vascular endothelial growth factor receptor (VEGFR-2, VEGFR-3), and epidermal growth factor receptor and to a
T36368	2H-Cho-Arg (trifluoroacetate salt)
	2H-Cho-Arg is a steroid-based cationic lipid that contains a 2H-cholesterol skeleton coupled to an L-arginine head group and can be used to facilitate gene transfection. It forms a complex with plasmid DNA (pDNA) and decreases pDNA migration in an electrophoretic mobility shift assay at +/- charge ratios of 4 or higher. 2H-Cho-Arg facilitates transfection of a luciferase gene into H1299 cells, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and t...
T74752	AA-T3A-C12
	AA-T3A-C12 是一种茴香酰胺配体-栓系类脂质 (AA-lipidoid)。AA-T3A-C12 介导大量 RNA 递送和活化的成纤维细胞的转染。
T82398	Firefly Luciferase circRNA
	Firefly Luciferase circRNA 是一种从Photinus pyralis（萤火虫）分离的荧光素酶蛋白，适用于作为环状RNA转染的阳性对照，用于监测和优化转染效率。
T74314	14:1 EPC trifluoromethanesulfonate
	14:1 EPC trifluoromethanesulfonate是一种含有单不饱和14:1链的乙基磷脂酰胆碱(EPC)，具有转染活性，可用于活性分子输送。
T74239	DOSPA
	DOSPA 是一种阳离子脂质。DOSPA 制备 DNA 是一种很有前途的转染系统。
T63358	RET-IN-15
	RET-IN-15 是转染期间重排激酶 (RET) 的抑制剂，能够用于癌症的研究。
T63230	RET-IN-8
	RET-IN-8 是转染期间重排激酶 (RET) 的抑制剂，能够用于癌症的研究。
TP1811	LAH4
	The a-helix of the amphipathic peptide antibiotic LAH4 (KKALLALALHHLAHLALHLALALKKA-NH2) strongly interacts with phospholipid membranes, demonstrating in vitro transfection efficiencies comparable to those of commercially available reagents.
T75762	LAH4 TFA
	LAH4 TFA是一种两亲性肽抗生素，以α螺旋形式表现出显著的抗菌(antimicrobial)、核酸转染(nucleic acid transfection)及细胞穿透能力。它在传递质粒DNA方面显示出较高效能，并对细菌外膜中的阴离子脂质展现强烈亲和力。
T37534	DMPAC-Chol
	DMPAC-Chol is a cationic cholesterol derivative that has been used in liposome formation for gene transfection. Liposomes containing DMPAC-chol bind to DNA in a band shift assay and protect against serum nuclease degradation of DNA when used at lipsome:DNA ratios ranging from 2.5:1 to 10:1 w/w. DMPAC-Chol-containing liposomes also reduce viability of HepG2 cells by 63% when used at a concentration of 37.5 μg/ml.
T74470	3'Ome-m7GpppAmpG ammonium
	3'Ome-m7GpppAmpG ammonium 是一种三核苷酸帽类似物，含锁核酸(LNA)分子，具显著翻译效率。作为潜在的分子生物学工具，3'Ome-m7GpppAmpG ammonium 在mRNA疫苗、mRNA转染领域应用广泛，涵盖蛋白质生产、基因治疗以及抗癌免疫等方面。
T74469	3'Ome-m7GpppAmpG
	3'Ome-m7GpppAmpG为具有锁核酸(LNA)分子的三核苷酸帽类似物，显示出显著的翻译效率。作为mRNA疫苗和mRNA转染领域的潜在分子生物学工具，3'Ome-m7GpppAmpG适用于蛋白质生产、基因治疗和抗癌免疫等应用。
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T35582	H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)
	H-Arg-Gly-Asp-Cys-OH is a tetrapeptide that contains the arginine-glycine-aspartate (RGD) motif, a sequence that acts as a recognition site for various adhesion proteins.1It inhibits the binding of fibrinogen to endothelial cells and ADP-stimulated platelets with IC50values of 320 and 35 μM, respectively.2Implantation of titanium rods coated with H-Arg-Gly-Asp-Cys-OH increases bone formation in rat femurs.3H-Arg-Gly-Asp-Cys-OH has been conjugated to polyethylenimine to improve gene transfection ...
T37391	PSEM 308 hydrochloride
	PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels. Recommended concentration for use in mice is 5 mg/kg or lower. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Lovett-Barron et al (2012) Regulation of neu...
T36350	Cho-Arg (trifluoroacetate salt)
	Cho-Arg is a steroid-based cationic lipid that contains a cholesterol skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratios greater than or equal to 4. Cho-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence or absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...
T82497	eGFP circRNA
	eGFP circRNA，能够编码由Aequorea victoria水母分离得到的绿色荧光蛋白。作为哺乳动物细胞培养中的常规直接检测报告蛋白，其在509 nm波长下发出鲜明的绿光。eGFP circRNA作为环状RNA转染的首选阳性对照，对于监测及提升转染效率具有重要意义。
T36359	Dios-Arg (trifluoroacetate salt)
	Dios-Arg is a steroid-based cationic lipid that contains a diosgenin skeleton coupled to an L-arginine head group. It forms a complex with plasmid DNA and decreases plasmid DNA migration in an agarose-gel retardant assay at charge ratio greater than or equal to 4. Dios-Arg facilitates transfection of plasmid DNA into H1299 and HeLa cells in the presence and absence of fetal bovine serum, an effect that is reversed by the lipid raft-mediated endocytosis inhibitor methyl-β-cyclodextrin and the cav...

化合物

Cat.No: T19080

Synonym: 1,2-二油酰-SN-甘油-3-磷酰乙醇胺

Target: Others

Cat.No: T11086

Synonym: (2,3-二油氧基丙基)三甲基氯化铵,1,2-Dioleoyl-3-trimethylammonium-propane chloride

Target: Others

Cat.No: T12598

Target: VEGFR, c-RET

Cat.No: T8902

Synonym: Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride,N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium

Target: Others

Cat.No: TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

Cat.No: T32780

trans-Pralsetinib

Cat.No: T10823

Synonym: cis-Pralsetinib,cis-BLU-667

Target: c-RET

Cat.No: T39313

Vandetanib Fumarate

Cat.No: T1656L

Synonym: HSDB 8198,Zactima,Caprelsa,ZD 6474,Vandetanib

2H-Cho-Arg (trifluoroacetate salt)

Cat.No: T36368

Cat.No: T74752

Firefly Luciferase circRNA

Cat.No: T82398

14:1 EPC trifluoromethanesulfonate

Cat.No: T74314

Cat.No: T74239

Cat.No: T63358

Cat.No: T63230

Cat.No: TP1811

Cat.No: T75762

Cat.No: T37534

3'Ome-m7GpppAmpG ammonium

Cat.No: T74470

3'Ome-m7GpppAmpG

Cat.No: T74469

Cat.No: T71576

H-Arg-Gly-Asp-Cys-OH (trifluoroacetate salt)

Cat.No: T35582

PSEM 308 hydrochloride

Cat.No: T37391

Cho-Arg (trifluoroacetate salt)

Cat.No: T36350

Cat.No: T82497

Dios-Arg (trifluoroacetate salt)

Cat.No: T36359

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