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11

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1289	Cardiotoxin Analog (CTX) IV (6-12) TFA Cardiotoxin Analog (CTX) IV (6-12) (TFA)(115722-23-1,FREE)	Others	Others
	Cardiotoxin Analog (CTX) IV (6-12) TFA(115722-23-1 free base) 是 Cardiotoxin Analog (CTX) IV 的部分肽。从台湾眼镜蛇毒液中分离出的心脏毒素类似物 IV。 CTX IV 是一种独特的蛇毒心脏毒素。
T26212	SQ 20858 SQ 20,858,SQ20858,SQ-20858,SQ-20,858,SQ20,858
	SQ 20858 is a synthetic peptide derived from snake Bothrops jararaca venom; suppresses angiotensin serum converting enzyme.
T80468	δ-Dendrotoxin	Potassium Channel	Membrane transporter/Ion channel
	δ-Dendrotoxin，作为一种K+通道阻滞剂，来源于黑曼巴蛇的毒液，常用于研究神经系统疾病。
T81787	MitTx-beta
	MitTx-beta为一多肽，源自得克萨斯珊瑚蛇(Micrurus tener tener)之毒液。与MitTx-α配对，组成复合物MitTx，此复合物激活ASIC1通道，存在于辣椒素敏感神经纤维上。
T80064	Dendrotoxin-I DTX-I	Potassium Channel	Membrane transporter/Ion channel
	Dendrotoxin-I是一种高效的K+通道阻滞剂，特异性针对KV1.1和KV1.2电压门控钾通道亚基。该化合物为从Dendroaspis蛇毒中提取的神经毒素。
T75582	Naja Melanoleuca Venom
	Naja Melanoleuca Venom (Forest Cobra Venom) 是一种蛇毒，可从 Naja Melanoleuca 获得。Naja Melanoleuca Venom 对人类红细胞具有溶血活性。α-神经毒素可以从 Naja Melanoleuca 毒液中分离出来，并抑制 GABAA 受体功能。
T75408	Batroxobin
	Batroxobin (DF-521)，一种从Bothrops atrox moojeni获得的蛇毒，能促进血栓溶解，防止血栓复发并具有神经保护作用，显示出在脑静脉血栓性疾病研究中的潜力。
T80487	MmTx2 toxin Micrurotoxin 2	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	MmTx2 toxin作为一种GABAA受体调节剂，具有提升GABAA受体对激动剂反应敏感性的作用。该毒素来源于珊瑚蛇的毒液，并在神经系统相关疾病（例如癫痫、精神分裂症及慢性疼痛）的研究中发挥重要用途。
T75585	Naja Mossambica Venom
	Naja Mossambica Venom (Mozambique Spitting Cobra Venom) 是一种蛇毒，可从 Naja Mossambica 获得。Naja Pallida Venom 对Candida 物种具有抗真菌活性。Naja Mossambica Venom 提取物 (如磷脂酶 A2) 可抑制钠钾 ATP 酶活性。
T75589	Bitis Cornuta Venom
	Bitis Cornuta Venom (Many-horned Adder Venom) 是从 Bitis Cornuta 提取的蛇毒，含有sPLA2毒素，该毒素具有通过抑制凝血酶原复合物以发挥抗凝活性的能力，并能促使凝血酶原转化为凝血酶，引发凝块形成。
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...

化合物

Cardiotoxin Analog (CTX) IV (6-12) TFA

Cat.No: TP1289

Synonym: Cardiotoxin Analog (CTX) IV (6-12) (TFA)(115722-23-1,FREE)

Target: Others

Cat.No: T26212

Synonym: SQ 20,858,SQ20858,SQ-20858,SQ-20,858,SQ20,858

Cat.No: T80468

Target: Potassium Channel

Cat.No: T81787

Cat.No: T80064

Synonym: DTX-I

Target: Potassium Channel

Naja Melanoleuca Venom

Cat.No: T75582

Cat.No: T75408

Cat.No: T80487

Synonym: Micrurotoxin 2

Target: GABA Receptor

Naja Mossambica Venom

Cat.No: T75585

Bitis Cornuta Venom

Cat.No: T75589

Cat.No: T37832

Synonym: CAY10761

Cat. No.	Product Name	Target	Signaling Pathways
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
TN4886	Quinovic acid 3-O-alpha-L-rhamnopyranoside	Others	Others
	Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.
TN4247	Ikshusterol 3-O-glucoside	Phospholipase	Metabolism
	Ikshusterol 3-O-glucoside has a potent snake-venom neutralizing capacity and it might be a potential molecule for the therapeutic treatment for snakebites.
T36295	Echistatin TFA
	Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of αIIbβ3, αvβ3 and α5β1[1][2][3][4]. [1]. J Musial, et al. Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation. 1990 Jul;82(1):261-73.[2]. ...

天然产物

Cat.No: TN1788

Target: Amylase

Quinovic acid 3-O-alpha-L-rhamnopyranoside

Cat.No: TN4886

Target: Others

Ikshusterol 3-O-glucoside

Cat.No: TN4247

Target: Phospholipase

Cat.No: T36295

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