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Search Results for " spla2-iia "

Targets Recommended: Phospholipase

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T2044	Varespladib LY315920,伐瑞拉地,伐瑞拉迪	Phospholipase	Metabolism
	Varespladib (LY315920) 是选择性group IIA, secretory phospholipase A2(sPLA2)抑制剂，其IC50=9 nM。它对大鼠，兔，豚鼠和人等各种物种血清的sPLA2活性具有明显的抑制作用，IC50分别为 8.1 nM，5.0 nM，3.2 nM 和 6.2 nM。
T81115	sPLA2-IIA Inhibitor
	sPLA2-IIA Inhibitor 是 FLSYK 的环状五肽类似物，具有环2-Nal-Leu-Ser-2-Nal-Arg (c2) 结构，能够特异性结合 hGIIA（人类 IIA 磷脂酶 A2），有效抑制其酯键水解活性。该化合物作为酯酶超家族的一员，主要作用于甘油磷脂 sn-2 位置的酯键，从而阻断游离脂肪酸和花生四烯酸等物质的释放。
T12990	sPLA2-X Inhibitor 31	Others	Others
	sPLA2-X Inhibitor 31 is a selective inhibitor of secreted phospholipase A2 type X (sPLA2-X) (IC50s of 26 nM, 310 nM, and 2230 nM for sPLA2-X, sPLA2-IIa, and sPLA2-V, respectively).
T27731	sPLA2 inhibitor 1 KH-064,KH 064,KH064,5-BPP acid
	KH064 is a sPLA2-IIA inhibitor of oral activity.
T30831	Cgp 43182 Cgp-43182,Cgp43182
	CGP 43182 is an effective inhibitor of group IIA secretory phospholipase A2 (Group IIA sPLA2) activity in vitro, which can be used to prevent the synergistic effect of pro-inflammatory genes stimulated by cytokines mediated by NFkappaB.
T39173	Varespladib sodium LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠
	Varespladib sodium (LY315920 sodium) is a highly potent and selective inhibitor of group IIA secretory phospholipase A2 (sPLA2), with an IC50 of 9 nM. It demonstrates significant inhibitory activity against sPLA2 in serum samples from multiple species, including rat, rabbit, guinea pig, and human, with IC50 values of 8.1 nM, 5.0 nM, 3.2 nM, and 6.2 nM, respectively.
T37785	1-Palmitoyl-2-linoleoyl PE
	Phosphatidylethanolamines are important components of cell membranes and biochemical pathways of fatty acid synthesis. 1-Palmitoyl-2-linoleoyl PE (PLPE) is one of the many phosphatidylethanolamines that may be present in cellular membranes. It has been used in studies involving the biosynthesis of anandamide via the phospholipase A2 (PLA2) and lysoPLD pathways. PLPE can also be used as a specific substrate to assess the activity of sPLA2-IIA in the presence of other phospholipids.

化合物

Varespladib

Cat.No: T2044

Synonym: LY315920,伐瑞拉地,伐瑞拉迪

Target: Phospholipase

sPLA2-IIA Inhibitor

Cat.No: T81115

Synonym:

Target:

sPLA2-X Inhibitor 31

Synonym: KH-064,KH 064,KH064,5-BPP acid

Target:

Cgp 43182

Cat.No: T30831

Synonym: Cgp-43182,Cgp43182

Target:

Varespladib sodium

Cat.No: T39173

Synonym: LY315920 sodium,伐瑞拉迪钠；伐瑞拉地钠

Target:

1-Palmitoyl-2-linoleoyl PE

Cat.No: T37785

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T2907	Tanshinone I 丹参酮I,Tanshinone A	Phospholipase	Metabolism
	Tanshinone I (Tanshinone A) 是IIA 型人重组sPLA2(IC50=11 μM)和兔重组cPLA2(IC50=82 μM)抑制剂。

天然产物

Tanshinone I

Cat.No: T2907

Synonym: 丹参酮I,Tanshinone A

Target: Phospholipase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04912	PLA2G2A Protein, Mouse, Recombinant (His) Pla2,sPLA2,sPla2	Mouse	P. pastoris (Yeast)
	PLA2G2A Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 15.3 kDa and the accession number is P31482.
TMPY-01705	PLA2G2A Protein, Human, Recombinant (His) PLAS1,phospholipase A2, group IIA (platele...	Human	HEK293 Cells
	PLA2G2A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024RA96.