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Cat. No.	Product Name	Target	Signaling Pathways
T9577	HCV-IN-31	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	HCV-IN-31 是一种HCV 抑制剂，EC50/EC95值为15.7 μM。
T15573	Inarigivir soproxil SB9200	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Inarigivir soproxil (SB9200) 是一种先天免疫激动剂。它还显示出针对耐药丙型肝炎病毒 (HCV) 变体的有效抗病毒活性。在基因型 1 HCV 复制子系统细胞中， HCV 1a/1b 的 EC50 为 2.2 和 1.0 μM。
T6229	Daclatasvir Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir (EBP 883) 是一种高度选择性的 HCV NS5A 抑制剂，EC50 为 9-50 pM，适用于细胞培养中的多种 HCV 复制子基因型和 JFH-1 基因型 2a 感染性病毒。
T1786	Daclatasvir dihydrochloride BMS-790052 dihydrochloride,盐酸达拉他韦	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) 是有机阴离子转运多肽 1B(OATP1B) 和 OATP1B3抑制剂，IC50分别为 1.5 µM 和 3.27 µM。它也具有口服活性的 HCV NS5A 蛋白抑制剂，多种 HCV 复制子基因型的 EC50范围为 9-146 pM。
T22142	RO8191 RO4948191,CDM-3008	HCV Protease; HBV; JAK; IFNAR; STAT	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Proteases/Proteasome; Stem Cells
	RO8191 (CDM-3008) 是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合，激活 IFN 刺激的基因表达和 JAK/STAT 磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用，并具有抗 HBV 活性。
TQ0162	R-1479 4'-Azidocytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	R-1479 (4'-Azidocytidine) 是一种 RdRp 抑制剂，对于 HCV 亚基因组复制子系统中的 HCV RNA 复制，IC50 值为 1.28 μM。
T16088	MK-0608	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	MK-0608 是一种可口服的体外 HCV 复制抑制剂。在亚基因组复制子测定中，EC50值为 0.3 μM，EC90值为 1.3 μM。
T9249	ITMN4077	Antiviral	Immunology/Inflammation
	ITMN4077 对感染人类 HuH7 细胞的丙型肝炎病毒具有抗病毒活性，评估为抑制 HCV 亚基因组复制子复制，EC50 为 2.131μM。
T7215	NM107 NM-107,2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	NM107 (2'-C-Methylcytidine) 是一种具有广谱抗病毒活性的核糖核苷，是丙型肝炎病毒 NS5B 聚合酶的核苷抑制剂，在野生型复制子细胞中的 EC50 为 1.85 μM。
T4988	Boceprevir SCH 503034,EBP 520,波普瑞韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Boceprevir (SCH 503034) 是一种口服有效的选择性 HCV NS3 蛋白酶抑制剂。在酶试验中的 Ki 为 14 nM，在基于细胞的复制子试验中 EC90 为 350 nM。它也是 SARS-CoV-2 3CLpro 抑制剂。
T3334	Velpatasvir GS-5816,维帕他韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Velpatasvir (GS-5816) 是一种的 HCV NS5A 抑制剂。它也是 SARS-CoV 3CLpro 的抑制剂，IC50为 2.16 μM。
T6729	Lomibuvir VX-222,VCH-222	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	Lomibuvir (VCH-222) (VX-222) 是丙型肝炎病毒 NS5B 聚合酶的一种非核苷变构抑制剂，Kd 值为 17 nM，已证明具有临床疗效。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T60531	2'-C-Methyladenosine	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	2'-C-Methyladenosine 是丙型肝炎病毒(HCV)复制的抑制剂，分离自肾棒状杆菌。2'-C-Methyladenosine 抑制 HCV 复制子和 NS5B 催化的 RNA 合成，IC50值分别为 0.3 μM 和 1.9 μM。2'-C-Methyladenosine 还对Leishmania guyanensis (Lgy)和Leishmania braziliensis中的 LRV1有抑制作用。
T6200	Ledipasvir GS-5885,雷迪帕韦	HCV Protease; SARS-CoV	Microbiology/Virology; Proteases/Proteasome
	Ledipasvir (GS-5885) 是一种丙型肝炎病毒 NS5A 抑制剂。它也是 P-糖蛋白抑制剂和乳腺癌抗性蛋白抑制剂。
T38237	2′-O-Methylcytidine	Nucleoside Antimetabolite/Analog; HCV Protease	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	2'-O-Methylcytidine 是 2'-代核苷，可抑制 HCV 复制。它在体外抑制 NS5B 催化的 RNA 合成，其抑制方式是与底物核苷三磷酸竞争。
T64202	HCV-IN-40
	HCV-IN-39 (Compound 18a) 是一种有效的、口服具有活力的 hepatitis C virus (HCV) 核苷抑制剂，能够作用于 GT1a 复制子 (EC50: 0.259 μM)、GT1b 复制子 (EC50: 0.434 μM) 和 GT1b CES1 复制子 (EC50: 0.069 μM)。
T70274	FR171456
	FR171456 is a natural specific inhibitor of mammalian nsdhl and yeast erg26p, inhibiting an artificial hepatitis c viral replicon, and showung broad antifungal activity
T11832	Ledipasvir D-tartrate GS-5885 D-tartrate,雷迪帕韦 D-酒石酸	Others	Others
	Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.
T15631	JTK-853	Others	Others
	JTK-853 is a novel, non-nucleoside inhibitor of Hepatitis C Virus (HCV) polymerase. It also displays effective antiviral activity in HCV replicon cells (EC50s: 0.38 and 0.035 µM in genotype 1a H77 and 1b Con1 strains, respectively).
T27125	DBPR-110 MB110,MB 110,MB-110
	DBPR-110 is a nonstructural protein 5A (NS5A) inhibitor. DBPR-110 reduced the reporter expression of the HCV1b replicon with a EC(50) and a selective index value of 3.9 ± 0.9 pM and >12,800,000, respectively. DBPR-110 reduced HCV2a replicon activity with
T75241	Ledipasvir hydrochloride GS-5885 hydrochloride
	Ledipasvir (GS-5885) hydrochloride 是抗HCV NS5A 的高效抑制剂，对GT1a 和 GT1b 复制子抑制作用显著，其EC50值仅为34 pM 和 4 pM。此外，Ledipasvir hydrochloride 还能抑制 SARS-CoV 3CLpro， IC50 为1.62 μM。
T12959	Sofosbuvir impurity D	Others	Others
	Sofosbuvir impurity D is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12960	Sofosbuvir impurity E	Others	Others
	Sofosbuvir impurity E is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T16715	Furaprofen 呋喃洛芬,R803	Others	Others
	Furaprofen is substantially more potent against genotype 1a and 1b replicons (EC50, ~30 nM) than against the genotype 2a replicon (EC50:1000 nM). Furaprofen is an effective HCV replication inhibitor.
T12954	Sofosbuvir 13CD3 GS-7977 13CD3,PSI-7977 13CD3	Others	Others
	Sofosbuvir 13CD3 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T63593	Dasabuvir sodium
	Dasabuvir (ABT-333) sodium 是非核苷丙型肝炎病毒 (HCV) 聚合酶抑制剂。Dasabuvir sodium 对 HCV NS5B 基因编码的 RNA 依赖性 RNA 聚合酶 (RNA polymerase) 表现出抑制作用。Dasabuvir sodium 能够抑制基因型 1a (菌株 H77) 复制子 (EC50: 7.7 nM) 和 1b (菌株 Con1) 复制子 (EC50: 1.8 nM)。
T12958	Sofosbuvir impurity C	Others	Others
	Sofosbuvir impurity C is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay,with potent anti-hepatitis C virus (HCV) activity.
T12955	Sofosbuvir D6 PSI-7977 D6,GS-7977 D6	Others	Others
	Sofosbuvir D6 is the deuterium labeled Sofosbuvir. Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
T71085	BMS-824
	BMS-824 is a potent NS5A inhibitor. The 50% inhibition of HCV replicon replication for BMS-824 was approximately 5 nM, with a therapeutic index of >10,000. BMS-824 showed good specificity for HCV, as it was not active against several other RNA and DNA viruses.
T12957	Sofosbuvir impurity B	Others	Others
	Sofosbuvir impurity B is the less active impurity of Sofosbuvir. Sofosbuvir is an active HCV RNA replication inhibitor in the HCV replicon assay, with potent anti-hepatitis C virus (HCV) activity.
T74070	NHC-triphosphate tetrasodium
	NHC-triphosphate tetrasodium 是 NHC 的活性胞内磷酸盐代谢物 (intracellular metabolite)，以三磷酸盐的形式存在。NHC-triphosphate tetrasodium 是病毒聚合酶 (viral polymerase) 的弱底物替代物，会被并入HCV 复制子 RNA 中。
T29176	YKL-04-085 YKL 04085,YKL04-085,YKL 04-085,YKL-04085
	YKL-04-085 is a potent inhibitor of viral translation. YKL-04-085 has cellular antiviral activity at 35-fold lower concentrations relative to inhibition of host-cell proliferation. YKL-04-085 demonstrated good inhibition of translation of the DENV2(GVD) r
T60440	Antiviral agent 17
	Antiviral agent 17 (Compound 4) 是一种抗感染剂，在人类复制子试验中显著保留其抗病毒作用，EC50值为0.015 μM。Antiviral agent 17 对小鼠诺如病毒(MNV)表现出良好的抗病毒活性。Antiviral agent 17 在研究传染性和恶性疾病方面具有潜力。
T36881	NHC-diphosphate triammonium
	NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono...
T73814	cis-Lomibuvir
	cis-Lomibuvir (cis-VX-222) 是 Lomibuvir 的顺式异构体。Lomibuvir (VX-222) 是一种选择性的非核苷聚合酶抑制剂，靶向丙型肝炎病毒 NS5B 聚合酶 (RdRp) 的拇指口袋 2，Kd 为 17 nM。Lomibuvir 抑制 1b/Con1 型 HCV 亚基因组复制子，EC50为 5.2 nM。Lomibuvir 优先抑制延长的 RNA 合成，而非从头合成的 RNA。
T16274	Narlaprevir SCH 900518,那拉匹韦	Others	Others
	Narlaprevir is an effective, selective, and orally bioavailable NS3 protease inhibitor(Ki=6 nM; EC90=40 nM).

化合物

Cat.No: T9577

Target: HCV Protease

Inarigivir soproxil

Cat.No: T15573

Synonym: SB9200

Target: HCV Protease

Cat.No: T6229

Synonym: Daklinza,达卡他韦,EBP 883,达拉他韦,BMS-790052

Target: HCV Protease

Daclatasvir dihydrochloride

Cat.No: T1786

Synonym: BMS-790052 dihydrochloride,盐酸达拉他韦

Target: HCV Protease

Cat.No: T22142

Synonym: RO4948191,CDM-3008

Target: HCV Protease, HBV, JAK, IFNAR, STAT

Cat.No: TQ0162

Synonym: 4'-Azidocytidine

Target: HCV Protease

Cat.No: T16088

Target: HCV Protease

Cat.No: T9249

Target: Antiviral

Cat.No: T7215

Synonym: NM-107,2'-C-甲基胞嘧啶核苷,2'-C-Methylcytidine

Target: HCV Protease

Cat.No: T4988

Synonym: SCH 503034,EBP 520,波普瑞韦

Target: HCV Protease, SARS-CoV

Cat.No: T3334

Synonym: GS-5816,维帕他韦

Target: HCV Protease, SARS-CoV

Cat.No: T6729

Synonym: VX-222,VCH-222

Target: HCV Protease

2'-C-Methyladenosine

Cat.No: T60531

Target: HCV Protease

Cat.No: T6200

Synonym: GS-5885,雷迪帕韦

Target: HCV Protease, SARS-CoV

2′-O-Methylcytidine

Cat.No: T38237

Target: Nucleoside Antimetabolite/Analog, HCV Protease

Cat.No: T64202

Cat.No: T70274

Ledipasvir D-tartrate

Cat.No: T11832

Synonym: GS-5885 D-tartrate,雷迪帕韦 D-酒石酸

Target: Others

Cat.No: T15631

Target: Others

Cat.No: T27125

Synonym: MB110,MB 110,MB-110

Ledipasvir hydrochloride

Cat.No: T75241

Synonym: GS-5885 hydrochloride

Sofosbuvir impurity D

Cat.No: T12959

Target: Others

Sofosbuvir impurity E

Cat.No: T12960

Target: Others

Cat.No: T16715

Synonym: 呋喃洛芬,R803

Target: Others

Sofosbuvir 13CD3

Cat.No: T12954

Synonym: GS-7977 13CD3,PSI-7977 13CD3

Target: Others

Dasabuvir sodium

Cat.No: T63593

Sofosbuvir impurity C

Cat.No: T12958

Target: Others

Cat.No: T12955

Synonym: PSI-7977 D6,GS-7977 D6

Target: Others

Cat.No: T71085

Sofosbuvir impurity B

Cat.No: T12957

Target: Others

NHC-triphosphate tetrasodium

Cat.No: T74070

Cat.No: T29176

Synonym: YKL 04085,YKL04-085,YKL 04-085,YKL-04085

Antiviral agent 17

Cat.No: T60440

NHC-diphosphate triammonium

Cat.No: T36881

Cat.No: T73814

Cat.No: T16274

Synonym: SCH 900518,那拉匹韦

Target: Others

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