Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A.
产品描述 | Ledipasvir D-tartrate with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. is an inhibitor of the hepatitis C virus NS5A. |
靶点活性 | GT1a:(EC50)34 pM , GT1b: 4 pM |
体外活性 | Ledipasvir is highly protein-bound both in human serum and in the cell-culture medium (containing 10% BSA) of the replicon assay[1]. Ledipasvir exhibits an EC50 value of 141 nM against the JFH/3a-NS5A replicon[2].?Ledipasvir has GT1a and 1b EC50 values of 31 and 4 pM, respectively, and protein-adjusted EC50 values of 210 pM (GT1a) and 27 pM (GT1b) and the intrinsic EC50 of 39 is 310 fM for GT1a and 40 fM for GT1b. |
体内活性 | Ledipasvir shows good half-lives (rat 1.83 ± 0.22 hr, dog 2.63 ± 0.18 hr) in plasma, low systemic clearance (CL), and moderate volumes of distribution (Vss) that are greater than total body water volume[1].Ledipasvir is remarkable not only on the basis of its high replicon potency but also on the basis of its low clearance, good bioavailability, and long half-lives in rat, dog, and monkey and low predicted clearance in human.?The pharmacokinetics of Ledipasvir is measured in rats and dogs. |
别名 | GS-5885 D-tartrate, 雷迪帕韦 D-酒石酸 |
分子量 | 1039.104 |
分子式 | C53H60F2N8O12 |
CAS No. | 1502654-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 28 mg/mL (26.95 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.9624 mL | 4.8118 mL | 9.6237 mL | 24.0592 mL |
5 mM | 0.1925 mL | 0.9624 mL | 1.9247 mL | 4.8118 mL | |
10 mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 2.4059 mL | |
20 mM | 0.0481 mL | 0.2406 mL | 0.4812 mL | 1.203 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ledipasvir D-tartrate 1502654-87-6 Others GS-5885 D-tartrate Ledipasvir D tartrate Ledipasvir Dtartrate 雷迪帕韦 D-酒石酸 Inhibitor inhibitor inhibit