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Search Results for " pyridone "

10

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3080	Pyridone 6 Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I	Tyrosine Kinases; JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Pyridone 6 (JAK Inhibitor) 是一种泛JAK 抑制剂，有效抑制 JAK 激酶家族，对JAK2、TYK2、JAK3和JAK1的IC50分别为 1、1、5 和 15 nM。
T2253	TCS PIM-1 1 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	TCS PIM-1 1 (SC 204330) 是一种特异性有效的 ATP 竞争性 Pim-1 激酶抑制剂，IC50为 50 nM，对 MEK1/MEK2 和 Pim-2 表现出良好的特异性，IC50值大于 20000 nM。
T13146	Thienopyridone	Others	Others
	Thienopyridone is a potent and selective inhibitor of phosphatase of regenerating liver (PRL) phosphatase(IC50s of 173 nM, 277 nM and 128 nM for PRL-1, PRL-2, and PRL-3, respectively), and induces p130Cas cleavage and apoptosis and has anticancer effects.
T60774	NITD-916 NITD916,NITD 916	Antibiotic	Microbiology/Virology
	NITD-916 是一种具有口服活性和高度亲脂性的分枝杆菌烯酰还原酶 InhA 抑制剂，IC50 为 570 nM。NITD-916是一种有有效的 4-羟基-2-吡啶酮衍生物，与 InhA 和 NADH 形成三元复合物，阻止进入脂肪酰基底物结合袋。NITD-916 具有抗结核活性。
T71459	PD 163449
	PD 163449 is a bioactive molecule of 4-pyridone group that inhibits bacterial type IIA topoisomerase (DNA gyrase and topoisomerase IV).
T38230	Iromycin A
	Iromycin A is a bacterial pyridone metabolite that inhibits nitric oxide synthase (NOS) activity, with selectivity for NOS III (endothelial NOS) over NOS I (neuronal NOS). Iromycin metabolites and derivatives block NADH oxidation in beef heart submitochondrial particles (IC50 = 0.461 μM for iromycin A).
T29527	ABT-255 ABT 255,ABT255,UNII-YA04O24J4T
	ABT-255 is a novel 2-pyridone antimicrobial agent for the treatment of tuberculosis. Both drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis showed efficacy in vitro and in vivo.
T34310	RG 14921 RG14921,RG-14921
	RG 14921 is a pyridone analog of erbstatin, epidermal growth factor (EGF) receptor tyrosine kinase, and cAMP-dependent kinase.
T83090	Anticancer agent 131
	HCT-116-IN-1, 一种与γ-内酰胺融合的吡啶酮衍生物，展现了针对HCT116细胞的强抗癌活性，其细胞毒性测定显示IC50值为5.59 μM。
T64138	Cap-dependent endonuclease-IN-16
	Cap-dependent endonuclease-IN-16 是一种吡啶酮多环衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-16 表现出潜力进行流感的研究。

化合物

Cat.No: T3080

Synonym: Janus-Associated Kinase Inhibitor I,JAK Inhibitor,CMP 6,吡啶酮6,JAK Inhibitor I

Target: Tyrosine Kinases, JAK

Cat.No: T2253

Synonym: 3-氰基-4-苯基-6-(3-溴-6-羟基苯基)-2(1H)-吡啶酮,SC 204330

Target: Pim

Cat.No: T13146

Target: Others

Cat.No: T60774

Synonym: NITD916,NITD 916

Target: Antibiotic

Cat.No: T71459

Cat.No: T38230

Cat.No: T29527

Synonym: ABT 255,ABT255,UNII-YA04O24J4T

Cat.No: T34310

Synonym: RG14921,RG-14921

Anticancer agent 131

Cat.No: T83090

Cap-dependent endonuclease-IN-16

Cat.No: T64138

Cat. No.	Product Name	Target	Signaling Pathways
T4805	α-Pyridone 2-Hydroxypyridine,2-羟基吡啶	Others; Endogenous Metabolite	Metabolism; Others
	α-Pyridone (2-Hydroxypyridine) 是内源性代谢产物的一种。
TN6092	Aspyridone A
	Aspyridone A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6092，CAS号为 935863-26-6。
T75455	Paecilomide
	Paecilomide，吡啶酮生物碱，是一种乙酰胆碱酯酶 (acetylcholinesterase) 抑制剂。

天然产物

Cat.No: T4805

Synonym: 2-Hydroxypyridine,2-羟基吡啶

Target: Others, Endogenous Metabolite

Cat.No: TN6092

Cat.No: T75455

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