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Search Results for " prion "

29

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP2284	Prion Protein 106-126 (human)	Others	Others
	Prion peptide fragment that exhibits neurotoxicity
T9174	Icerguastat Sephin 1,lcerguastat,IFB-088	Phosphatase	Metabolism
	Icerguastat (IFB-088) 是一种缺乏 α2-肾上腺素能活性的 Guanabenz 衍生物，是一种磷酸酶调节亚单位 PPP1R15A (R15A)的选择性抑制剂。它能够抑制 eIF2α 去磷酸化，从而延长保护反应。它具有抗朊病毒作用。
T23450	TCS PrP Inhibitor 13 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One	Others	Others
	TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) 是一种抗朊病毒剂，可抑制蛋白酶抗性朊病毒蛋白的积累。它诱导神经鞘瘤细胞调亡，在ScN2a 和F3细胞株中均显示IC50值为3 nM。
T125601	Salprionin
	Salprionin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125601。
T124014	Prionoid B
	Prionoid B 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124014。
T124011	Prionoid E
	Prionoid E 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124011。
T124012	Prionoid D
	Prionoid D 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124012。
T124013	Prionoid C
	Prionoid C 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124013。
T25531	IND24 IND-24,IND 24	Antiviral	Immunology/Inflammation
	IND24 具有抗朊病毒活性，可用于研究神经退行性疾病。
T77786	TGFβ-IN-5 WAY-641966	TGF-beta/Smad	Stem Cells
	TGFβ-IN-5 (WAY-641966) 是一种有效的 TGFβ 抑制剂，具有抗朊病毒活性，可用于研究与 TGF-β 信号转导相关的纤维增殖性疾病。
T5447	Anle138b	Beta Amyloid; Others	Neuroscience; Others
	Anle138b 是一种毒性低，口服生物利用度高，血脑屏障通透性好的低聚物聚集抑调节剂，可阻断朊病毒蛋白和 α-突触核蛋白病理性聚集的形成。它在体内强烈抑制低聚物积累、神经元变性和疾病进展。它阻断 Aβ 通道并挽救淀粉样变性小鼠模型的疾病表型。
T40363	Poly-D-lysine hydrobromide (MW 30000-70000) Poly-D-lysine HBr (MW 30000-70000)	CaSR	GPCR/G Protein
	Poly-D-lysine hydrobromide (MW 30000-70000)(Poly-D-lysine HBr) 是一种可口服的肽类 CaSR 激动剂，可从朊病毒感染的 SN56 神经母细胞瘤细胞中去除蛋白酶 K 抗性的 PrP。
T62105	NT219 NT-219	STAT	JAK/STAT signaling; Stem Cells
	NT219 是一种胰岛素受体底物 1/2 (IRS1/2) 和STAT3的双重抑制剂，可增强错误折叠的朊病毒蛋白的聚集NT219 影响，可提高某些分子伴侣的水平，抑制 STAT3 磷酸化。NT219 具有研究癌症和神经退行性疾病。
T27314	Fe-TMPyP
	Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.
T23966	DB772 DB 772,DB-772
	DB772 is a scrapie prion accumulation inhibitor.
T61256	ARN1468
	ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
T25532	IND81 IND-81,IND 81
	IND81 is an antiprion agent that works by extending the lives of prion-infected animals.
T68763	PQQ-TME
	PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.
T63412	DB772 hydrate
	DB772 hydrate 是一种牛病毒性腹泻病毒 (BVDV) 抑制剂，同时表现出抗朊病毒作用。
T12563	PrPSc-IN-1	Others	Others
	PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrPSc, inhibits its accumulation(IC50 of 1.6 μM), with anti-prion activity.
T81312	Ralzapastotug AB-308
	Ralzapastotug (AB-308)是一种靶向朊病毒蛋白PrPC的106-126氨基酸片段的单克隆抗体。
T79038	Tau protein aggregation-IN-1
	Tau protein aggregation-IN-1（化合物 0c）是一种针对Tau protein聚集的抑制剂。该化合物主要应用于研究蛋白质折叠障碍类疾病，包括阿尔茨海默病、痴呆、帕金森病、亨廷顿舞蹈病及基于朊病毒引起的海绵状脑病。
T73416	BiCAPPA
	BiCAPPA 是一个二价抗朊病毒配体。BiCAPPA 可以减少痒病感染细胞中传染性构象形式的朊病毒蛋白 (PrPSc)，EC50值为 0.32 μM。
T60775	BB 0305179
	BB 0305179 (化合物 59) 抑制疏水结构域缺失的特定 PrP 突变体的毒性，是有效的抗朊病毒剂 (IC50 = 4.7 μM)。
T38146	Chloroguanabenz (acetate)
	Chloroguanabenz is an antiprion agent and a derivative of the α2-adrenergic receptor agonist guanabenz . It inhibits prion formation in yeast and mammalian cell-based assays. Chloroguanabenz reduces the levels of both soluble and aggregated forms of the truncated Huntingtin derivative Htt48 in an HEK293T cellular model of Huntington's disease.
T23210	Quinacrine (dihydrochloride hydrate) Quinacrine (hydrochloride hydrate) (83-89-6 free base)	Others	Others
	Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e
T36328	Termitomycamide B
	Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid i...
T38187	6-Aminophenanthridine
	6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz . 6-Aminophenanthridine (300 μM) inhibits protein folding activity of the ribosome (PFAR) by directly competing with protein substrates for the active site and decreases the yield of refolded protein without affecting the refolding rate. It prevents progressive w...
T83122	Amyloid-Forming peptide GNNQQNY
	Amyloid-Forming peptide GNNQQNY是由酵母蛋白Sup35的N-末端朊病毒决定结构域中得来的七肽段，具有生物活性，并能形成淀粉样纤维。它的详细原子低聚结构之研究，使其成为揭示早期聚集阶段的理想模型。GNNQQNY二聚体以三种稳定构形存在：寄存器内并排、寄存器外并排和反向并排。对准的平行二聚体其β-pleated sheet结构中肽链间氢键较少，强调了疏水作用的重要性，相较于反向并排结构有更高的构象熵。

化合物

Prion Protein 106-126 (human)

Cat.No: TP2284

Target: Others

Cat.No: T9174

Synonym: Sephin 1,lcerguastat,IFB-088

Target: Phosphatase

TCS PrP Inhibitor 13

Cat.No: T23450

Synonym: 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One

Target: Others

Cat.No: T125601

Cat.No: T124014

Cat.No: T124011

Cat.No: T124012

Cat.No: T124013

Cat.No: T25531

Synonym: IND-24,IND 24

Target: Antiviral

Cat.No: T77786

Synonym: WAY-641966

Target: TGF-beta/Smad

Cat.No: T5447

Target: Beta Amyloid, Others

Poly-D-lysine hydrobromide (MW 30000-70000)

Cat.No: T40363

Synonym: Poly-D-lysine HBr (MW 30000-70000)

Target: CaSR

Cat.No: T62105

Synonym: NT-219

Target: STAT

Cat.No: T27314

Cat.No: T23966

Synonym: DB 772,DB-772

Cat.No: T61256

Cat.No: T25532

Synonym: IND-81,IND 81

Cat.No: T68763

Cat.No: T63412

Cat.No: T12563

Target: Others

Cat.No: T81312

Synonym: AB-308

Tau protein aggregation-IN-1

Cat.No: T79038

Cat.No: T73416

Cat.No: T60775

Chloroguanabenz (acetate)

Cat.No: T38146

Quinacrine (dihydrochloride hydrate)

Cat.No: T23210

Synonym: Quinacrine (hydrochloride hydrate) (83-89-6 free base)

Target: Others

Termitomycamide B

Cat.No: T36328

6-Aminophenanthridine

Cat.No: T38187

Amyloid-Forming peptide GNNQQNY

Cat.No: T83122

Cat. No.	Product Name	Target	Signaling Pathways
TN6502	Prionanthoside
	Prionanthoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6502，CAS号为 161842-81-5。
TN5590	Prionidipene A
	Prionidipene A 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5590，CAS号为 2199455-72-4。
TN4830	Prionitin	Others	Others
	Prionitin is a natural product from Salvia prionitis Hance.

天然产物

Prionanthoside

Cat.No: TN6502

Prionidipene A

Cat.No: TN5590

Cat.No: TN4830

Target: Others

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