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Search Results for " polycyclic "

15

抑制剂 & 化合物

10

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21469	Cyclopenthiazide Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪	Others	Others
	Cyclopenthiazide (Cyclomethiazide) 是一种噻嗪类利尿剂，用于治疗高血压和心力衰竭。减少钙离子和尿酸的排泄，增加钠和钾离子的排泄。
T0352	Dibenzothiophene 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide	Others	Others
	Dibenzothiophene (Imino semicarbazide) 是有机合成过程的中间体，是由两个苯环稠合到一个中心的噻吩环。
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzymes, including the cytochrome P450 (CYP450) isoform CYP1B1, as well as microsomal epoxide hydrolase (mEH), producing a variety of reactive metabolites that form DNA adductsin vivo, and it has been commonly used to induce tumor formation in various rodent models.2,3,1DMBA increase...
T23994	Dibenzo(a,i)pyrene DB(a,i)p,Benzo(rst)pentaphene
	Dibenzo(a, i)pyrene is a polycyclic aromatic hydrocarbon with potent carcinogenic activity.
T25602	Laidlomycin Laidlomycinum,Laidlomicina
	Laidlomycin, a polyether, polycyclic, monocarboxylic acid, possesses inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.
T24992	A-130A Antibiotic A 130A,A 130A,Antibiotic Ro 21 6150,Lenoremycin
	A-130A is a polycyclic polyether compound belonging to the nigericin group of antibiotics generated by Streptomyces hygroscopicus strain.
T70432	MEN-10627
	MEN-10627 is a polycyclic peptide and tachykinin NK2 receptor antagonist.
T28756	Septamycin A 28695A,A28695A,A-28695A
	Septamycin is a polycyclic, polyether, monocarboxylic acid antibiotic. Septamycin is isolated from strain of Streptomyces albus.
T26406	A 204 Antibiotic A-204,Antibiotic A204,A-204,Antibiotic A 204,A204
	A 204 is a polycyclic polyether monocarboxylic acid antibiotic isolated from fermentation of strain of Streptomyces albus.
T39089	Acid secretion-IN-1
	Acid secretion-IN-1, a polycyclic compound, is synthesized for its application as an IDO inhibitor in synthetic experiments.
T26605	Alyssin
	Alyssin is a sulforaphane homolog and antioxidant. It induces phase II enzymes and increases Nrf2 levels in adenocarcinoma cells. It decreases the metabolism of polycyclic aromatic hydrocarbons, supressing the risk of carcinogenesis in vitro.
T81285	RGB-1
	RGB-1为多环芳烃类化合物，作为RNA G-四链体 (RNA G-quadruplexes) 的稳定剂，能够抑制RNA翻译，并在乳腺癌细胞中下调NRAS原癌基因的表达。
T64138	Cap-dependent endonuclease-IN-16
	Cap-dependent endonuclease-IN-16 是一种吡啶酮多环衍生物，也是一种 cap-dependent 核酸内切酶 (CEN) 的有效抑制剂。Cap-dependent endonuclease-IN-16 表现出潜力进行流感的研究。
T37031	Quinacrine mustard hydrochloride Quinacrine mustard HCl	Autophagy	Autophagy
	Quinacrine mustard hydrochloride 是一种荧光染料,也是一种多环芳香剂，可作为诱变剂诱导细菌的突变体。Quinacrine mustard hydrochloride 能选择性地与腺嘌呤-胸腺嘧啶（AT）碱基对结合，而不是与鸟嘌呤-胞嘧啶（GC）碱基对结合，诱导细胞周期停滞在 G2/M 期。Quinacrine mustard (hydrochloride) 已被用于标记移相染色体，以通过自动放射摄影技术进行核型分析。
T37006	Previridicatumtoxin
	Previridicatumtoxin is a fungal metabolite that has been found inP. aethiopicumand has diverse biological activities.1,2It is an intermediate in the biosynthesis of the mycotoxin viridicatumtoxin . Previridicatumtoxin is active against methicillin-resistantS. aureus(MRSA) and vancomycin-resistantE. faecalis(IC50s = 4.4 and 4.8 μM, respectively), as well asC. albicansandS. cerevisiae(MIC = 32 μg/ml for both).2,1It is cytotoxic to NCI H460, KB-3-1, and SW620 cancer cells (IC50s = 5.3, 4.1, and 6 μ...

化合物

Cyclopenthiazide

Cat.No: T21469

Synonym: Cyclomethiazide,Su-8341,SU 8341,环戊噻嗪

Target: Others

Dibenzothiophene

Cat.No: T0352

Synonym: 二苯并噻吩,Imino semicarbazide,Diphenylene sulfide

Target: Others

Cat.No: T36696

Dibenzo(a,i)pyrene

Cat.No: T23994

Synonym: DB(a,i)p,Benzo(rst)pentaphene

Cat.No: T25602

Synonym: Laidlomycinum,Laidlomicina

Cat.No: T24992

Synonym: Antibiotic A 130A,A 130A,Antibiotic Ro 21 6150,Lenoremycin

Cat.No: T70432

Cat.No: T28756

Synonym: A 28695A,A28695A,A-28695A

Cat.No: T26406

Synonym: Antibiotic A-204,Antibiotic A204,A-204,Antibiotic A 204,A204

Acid secretion-IN-1

Cat.No: T39089

Cat.No: T26605

Cat.No: T81285

Cap-dependent endonuclease-IN-16

Cat.No: T64138

Quinacrine mustard hydrochloride

Cat.No: T37031

Synonym: Quinacrine mustard HCl

Target: Autophagy

Previridicatumtoxin

Cat.No: T37006

Cat. No.	Product Name	Target	Signaling Pathways
T7914	Acenaphthylene	Others	Others
	Acenaphthylene 是多环芳烃。其中多环芳烃是自然衍生于煤和焦油沉积物中，并由有机质的不完全燃烧得到。
T19082	1-Hydroxypyrene 1-Pyrenol,Pyren-1-ol,1-羟基芘	Endogenous Metabolite	Metabolism
	1-Hydroxypyrene (1-Pyrenol) 是一种暴露于多环芳烃的生物标志物，存在尿液样本中，也是一种暴露于 pyrenes 中的主要生物标志物。
T14961	Chrysene 䓛,屈	Others	Others
	Chrysene 是高分子量 (HMW) 多环芳烃，有极强的顽固性和致癌性。
T2788	Baccatin III 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ	Others	Others
	Baccatin III (Baccatin Ⅲ) 是一种分离自太平洋紫杉树和其近缘种中的天然产物，能够减少 MDSCs 积累并抑制其功能，延缓肿瘤发展进程。
T3776	Rhapontigenin 丹叶大黄素,Protigenin	P450; Antibacterial; Antifungal	Metabolism; Microbiology/Virology
	Rhapontigenin (Protigenin) 是一种基于机制的选择性细胞色素 P450 1A1 (IC50: 400 nM) 灭活剂。它是一种芳烃羟化酶，可激活作为致癌物质的多环芳烃。它是白藜芦醇的天然类似物，具有抗癌，抗氧化剂，抗真菌和抗菌活性。
T25563	K 41 K-41,K41,Antibiotic K-41A,37454 RP,Antibiotic A 32887
	K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.
T27807	13-Methyltetradecanoic acid LeDSF3
	LeDSF3 is a regulator of the biosynthesis of the antifungal polycyclic tetramate macrolactam HSAF in Lysobacter enzymogenes and anti-tumor agent. LeDSF3 down-regulates p-AKT and activates caspase-3.
T75609	7-epi-Isogarcinol
	7-epi-Isogarcinol 是一种PPAP（多环聚异戊二烯酰基间苯三酚），显示出适度的抗增殖活性。它通过阻断STAT3信号通路，诱导apoptosis（细胞凋亡）并抑制细胞迁移作用。
TMA0897	Beta-Carboline-1-propanoic acid	Others	Others
	Beta-Carboline-1-propanoic acid 是一种参考标准化合物，也是一种合成前体化合物。它是吲哚的衍生物，已被用于合成其他吲哚衍生物，如吲哚-3-甲醛，也被用作合成多环芳香化合物的起始材料。它还被用于研究含吲哚化合物的构效关系，并被用作研究吲哚反应性的模型化合物。
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...

天然产物

Cat.No: T7914

Target: Others

1-Hydroxypyrene

Cat.No: T19082

Synonym: 1-Pyrenol,Pyren-1-ol,1-羟基芘

Target: Endogenous Metabolite

Cat.No: T14961

Synonym: 䓛,屈

Target: Others

Cat.No: T2788

Synonym: 巴卡亭 Ⅲ,浆果赤霉素III,Baccatin Ⅲ

Target: Others

Cat.No: T3776

Synonym: 丹叶大黄素,Protigenin

Target: P450, Antibacterial, Antifungal

Cat.No: T25563

Synonym: K-41,K41,Antibiotic K-41A,37454 RP,Antibiotic A 32887

13-Methyltetradecanoic acid

Cat.No: T27807

Synonym: LeDSF3

7-epi-Isogarcinol

Cat.No: T75609

Beta-Carboline-1-propanoic acid

Cat.No: TMA0897

Target: Others

Cat.No: T36954

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