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7

抑制剂 & 化合物

12

天然产物

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Cat. No. Product Name Target Signaling Pathways
T19051 Reactive Blue 4

活性艳蓝X-ARL,活性蓝4

Others Others
Reactive Blue 4 是蒽醌类染料,具有植物毒性、细胞毒性和基因毒性。它可作为单一的比色化学传感器,用于在水介质中连续测定具有不同光学响应的多种分析物。
T34441 Rubrobramide

Rubrobramide is a cytotoxic and phytotoxic metabolite from Cladobotyrum rubrobrunnescens.
T29927 AM Toxin III

AM Toxin III is a phytotoxic peptide.
T35771 Destruxin B2

Destruxin B2 is a cyclic hexadepsipeptide mycotoxin that has been found in M. anisopliae and has antiviral, insecticidal, and phytotoxic activities.1,2,3 It inhibits secretion of hepatitis B virus surface antigen (HBsAg) by Hep3B cells expressing hepatitis B virus (HBV) DNA (IC50 = 1.3 μM).1 Destruxin B2 is toxic to Sf9 insect cells in an electric cell-substrate impedance sensing (ECIS) test with a 50% inhibitory concentration (ECIS50) value of 92 μM.4 It is also phytotoxic to B. napus leaves.3 ...
T38274 Papyracillic Acid

Papyracillic acid is a fungal metabolite and a derivative of penicillic acid originally isolated fromL. papyraceumand has antibiotic, antifungal, and phytotoxic activities.1,2It is active against the bacteriaX. campestrisandB. subtilisand the fungusC. tropicalisin a disc assay when used at a concentration of 5 μg/disc.2Papyracillic acid (1 mg/ml) induces necrotic lesion formation in a panel of 10 plants. 1.Shan, R., Anke, H., Stadler, M., et al.Papyracillic acid, a new penicillic acid analogue f...
T35434 β-Cembrenediol

β-Cembrenediol (β-CBT) is a natural product from tobacco plants that is found in cigarette smoke condensate. β-CBT inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in vitro (IC50 = 21.9 μM). It inhibits tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation in vivo. β-CBT is also released into soil by flue-cured tobacco plants and exerts autotoxicity as well as phytotoxic activity against L....
T78585 Pentabromopseudilin

Pentabromopseudilin (PBrP) 为自Pseudomonas bromoutilis与Alteromonas luteoviolaceus两种海洋细菌中提取的海洋抗生素,展现抗菌、抗肿瘤及植物毒性活性。此化合物为肌球蛋白 Va(Myosin Va, MyoVa)的可逆构型抑制剂,并能有效抑制转化生长因子-β(Transforming Growth Factor-β, TGF-β)的活性,适用于纤维化疾病与癌症研究领域。

化合物

Reactive Blue 4
Cat.No: T19051
Synonym: 活性艳蓝X-ARL,活性蓝4
Target: Others
Rubrobramide
Cat.No: T34441
Synonym:
Target:
AM Toxin III
Cat.No: T29927
Synonym:
Target:
Destruxin B2
Cat.No: T35771
Synonym:
Target:
Papyracillic Acid
Cat.No: T38274
Synonym:
Target:
β-Cembrenediol
Cat.No: T35434
Synonym:
Target:
Pentabromopseudilin
Cat.No: T78585
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T9933 Methyl 2,4-dihydroxyphenylacetate

Others Others
Methyl 2,4-dihydroxyphenylacetate 是从 Nigella damascena 种子中分离得到的天然产物,具有选择性的植物毒性作用。
TN1739 Homodihydrocapsaicin I

高二氢辣椒素,高二氢辣椒素I

Others Others
Homodihydrocapsaicin I 是一种辣椒素,分离自辣椒果实中。
T26038 Radicinin

Stemphylone

Radicinin is used as a phytotoxic and antibiotic metabolite produced by some phytopathogenic fungi.
TN5331 Xanthinin

Xanthinin is a plant growth-regulating compound from Xanthium pennsylvanicum, it is also a phytotoxic xanthanolide, can inhibit the growth of plants.
T14196 Alternariol

Others Others
Alternariol (AOH), a mycotoxin synthesized by Alternaria species, displays numerous therapeutic and biological effects, including phytotoxic, cytotoxic, anti-HIV, anti-cancer, and anti-microbial properties. It functions by inhibiting the catalytic activity of topoisomerase I and II enzymes.
TN3862 Dihydroprehelminthosporol

Others Others
Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.
TN5091 Tagitinin A

PPAR; Antifection DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
Tagitinin A is a plant insecticidal compound, it has phytotoxic activity, it shows significant inhibition of wheat coleoptile growth, seed germination, and the growth of STS and weeds. Tagitinin A is also a PPARα/γ dual agonist , it exerts anti-diabetic e
TN3979 Epiyangambin

PAFR GPCR/G Protein
Epiyangambin is a phytotoxic lignan, it shows inhibition of seed germination of Agrostis stolonifera cv. penncross (Poaceae) and inhibition of development of Lactuca sativa L. (Asteraceae) seedlings in a microassay using 24-well plates. Epiyangambin exhibits significant inhibition of the transformation of murine epidermal JB6 cells, with the IC50 value of 0.15 microg/mL. (+)-Epiyangambin also has anti-platelet aggregation activity.
TN4261 Isoaltenuene

Antifection Microbiology/Virology
Isoaltenuene shows antibiotic activity against Gram-positive bacteria; it also shows a minor phytotoxic activity on tomato leaves at level of 20 ug/spot . Isoaltenuene exhibits cytotoxic activity against lung cancer cell line A549, breast cancer cell line
TN3930 Encecalin

ATPase Membrane transporter/Ion channel
Encecalin and demethylencecalin are major phytotoxic compounds isolated from Helianthella quinquenervis (Hook) A Gray (Asteraceae), they inhibit photosystem II (from water to 2,5-dibromo-3-methyl-6-isopropyl-1,4 p-benzo-quinone).They retard seed germinati
T37543 Anhydroepiophiobolin A

Anhydroepiophiobolin A is a sesterterpenoid fungal metabolite that has been found in B. oryzae. It is cytotoxic to HepG2 and K562 cells (IC50s = 47.1 and 35.6 μM, respectively) as well as A549, SKOV3, SK-MEL-2, XF498, and HCT15 cells (IC50s = 1.6-1.9 μg/ml). Anhydroepiophiobolin A is phytotoxic to S. viridis and D. erucoides in a leaf puncture assay.
TN4551 Methyl orsellinate

Phosphatase; cAMP; Antifection GPCR/G Protein; Metabolism; Microbiology/Virology
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. Methyl orsellinate can inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM, the selective inhibition of PTP1B has been widely recognized as a potential ...

天然产物

Methyl 2,4-dihydroxyphenylacetate
Cat.No: T9933
Synonym:
Target: Others
Homodihydrocapsaicin I
Cat.No: TN1739
Synonym: 高二氢辣椒素,高二氢辣椒素I
Target: Others
Radicinin
Cat.No: T26038
Synonym: Stemphylone
Target:
Xanthinin
Cat.No: TN5331
Synonym:
Target:
Alternariol
Cat.No: T14196
Synonym:
Target: Others
Dihydroprehelminthosporol
Cat.No: TN3862
Synonym:
Target: Others
Tagitinin A
Cat.No: TN5091
Synonym:
Target: PPAR, Antifection
Epiyangambin
Cat.No: TN3979
Synonym:
Target: PAFR
Isoaltenuene
Cat.No: TN4261
Synonym:
Target: Antifection
Encecalin
Cat.No: TN3930
Synonym:
Target: ATPase
Anhydroepiophiobolin A
Cat.No: T37543
Synonym:
Target:
Methyl orsellinate
Cat.No: TN4551
Synonym:
Target: Phosphatase, cAMP, Antifection
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