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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T73692	Parathyroid hormone
	Parathyroid hormone (PTH) 是一种含84个氨基酸的循环激素，由甲状旁腺分泌。它主要针对骨骼和肾脏工作，功能是维持细胞外钙浓度在正常水平。此外，Parathyroid hormone 在骨质疏松症的研究中有重要应用。
T21535	Parathyroid Hormone (1-34), bovine	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	Parathyroid Hormone (1-34), bovine 是一种甲状旁腺激素 (PTH) 受体激动剂，是甲状旁腺激素的一部分。 Parathyroid Hormone (1-34), bovine 可用于研究骨质疏松症和甲状旁腺功能衰退。
T36767	Parathyroid Hormone (1-13) (trifluoroacetate salt)
	Parathyroid hormone (PTH) (1-13) is an N-terminal fragment of PTH (1-34) . In vivo, PTH (1-13) (0.003-1 μmol/kg) increases mean arterial pressure (MAP) in anesthetized rats.
TP1964	Parathyroid hormone (1-34) (rat)
	Parathyroid hormone (PTH) receptor agonist. Increases serum PTH levels and bone mass in rats.
TP2283	parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]	Others	Others
	parathyroid hormone (7-34) [Homo sapiens] [Macaca fascicularis] is a peptide with the sequence H2N-LMHNLGKHLNSMERVEWLRKKLQDVHNF-OH, MW= 3474.03. Parathyroid hormone (PTH) is secreted by the chief cells of the parathyroid glands as a polypeptide containing
T13128	Teriparatide 特立帕肽,Human parathyroid hormone-(1-34),hPTH (1-34),PTH 1-34	Others	Others
	Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells).
T21460	Teriparatide acetate hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽	Others	Others
	Teriparatide acetate (Forteo) 是一种 PHT 激动剂，在 HEK293 细胞中的 IC50 为 2 nM。Teriparatide acetate 是一种重组形式的甲状旁腺激素。它是一种有效的合成代谢（即骨骼生长）剂，用于治疗某些形式的骨质疏松症。间歇使用特立帕肽比破骨细胞更能激活成骨细胞，从而导致骨骼整体增加。
T76084	Parathyroid Hormone (1-34), human, biotinylated
	Parathyroid Hormone (1-34), human, biotinylated 作为甲状旁腺激素受体的高效探针，其主要应用于活细胞中探索甲状旁腺激素与其受体之间的动态相互作用，并可利用亲和柱技术对激素-受体复合物进行精确纯化。
T76061	Parathyroid hormone (1-34) (rat) acetate
	Parathyroid hormone (1-34) (rat) (acetate) 是一种甲状旁腺激素，主要用于骨质疏松症的研究，具有改善皮质和松质骨结构的功能。
T75867	Parathyroid Hormone (1-34), bovine TFA
	Parathyroid Hormone (1-34), bovine TFA，作为一种高效的甲状旁腺激素(PTH)受体激动剂，能提升钙和无机磷酸盐的水平，适用于骨质疏松症的研究。
T2406	Cinacalcet hydrochloride AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet,盐酸西那卡塞	CaSR	GPCR/G Protein
	Cinacalcet hydrochloride (AMG-073 hydrochloride) 是口服有活性的Ca receptor (CaR)激动剂，可用于研究心血管疾病。
TP1215L	Abaloparatide acetate(247062-33-5 free base)	Others	Others
	Abaloparatide acetate(247062-33-5 free base) 是一种甲状旁腺激素受体 1 PTHR1 类似物，是 PTHR1 信号通路的有效和选择性激活剂。
T16015	Maxacalcitol 马沙骨化醇,22-Oxacalcitriol	Others	Others
	Maxacalcitol (22-Oxacalcitriol) 是非血钙维生素 D3的一种类似物，是 VDR 样受体的配体。
TP1215	Abaloparatide TFA BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA	Others	Others
	Abaloparatide TFA (BIM 44058 TFA) 是一种甲状旁腺激素相关蛋白 (PTHrP) 类似物药物，与相关药物特立帕肽一样用于治疗骨质疏松症。
T29067	Upacicalcet PLS-240,SK-1403,AJT-240	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Upacicalcet (AJT-240) 是一种静脉内拟钙剂，是一种可用于人血液透析的 SHPT，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。 3 Upacicalcet 是钙敏感受体的正变构调节剂，可预防大鼠腺嘌呤诱导的继发性甲状旁腺功能亢进模型中的血管钙化和骨骼疾病。
T9691L	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate 是一种高效的甲状旁腺激素 (PTH) 拮抗剂，在牛肾皮质膜中的 Ki 值为 69 nM。
TP1236	Etelcalcetide hydrochloride AMG 416 hydrochloride,维考西肽盐酸盐,KAI-4169 hydrochloride	CaSR	GPCR/G Protein
	Etelcalcetide hydrochloride (AMG 416 hydrochloride) 是具有有钙敏感受体 (CaSR) 活化剂作用的合成肽，能够减少接受血液透析的继发性甲状旁腺功能亢进患者的甲状旁腺激素 (PTH) 浓度。
TP1906L1	DPC AJ1951 acetate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	DPC-AJ1951 acetate 是一种 14 个氨基酸的肽，可作为甲状旁腺激素 (PTH)/PTH 相关肽受体 (PPR) 的有效激动剂。在骨吸收的体外和体内测定中表征了它的活性。
T29067L	Upacicalcet HCl Upacicalcet HCl(1333218-50-0 Free base)	CaSR	GPCR/G Protein
	Upacicalcet HCl 是一种静脉内拟钙剂，通过直接作用于甲状旁腺细胞膜钙敏感受体来抑制过量的甲状旁腺激素 (PTH) 分泌，从而降低血液中的 PTH 水平。Upacicalcet HCl 可用于治疗血液是一种新型继发性甲状旁腺功能亢进化合物，靶向钙敏感受体的氨基酸结合位点。
T10665	Calcium-Sensing Receptor Antagonists I	Others	Others
	Calcium-Sensing Receptor Antagonists I functions as an antagonist to the parathyroid hormone receptors that sense calcium.
T61232	(Rac)-Upacicalcet
	(Rac)-Upacicalcet is a racemate of Upacicalcet, which serves as an intravenous calcimimetic agent. Upacicalcet acts by directly targeting calcium-sensing receptors on parathyroid cell membranes, effectively suppressing the release of excessive parathyroid hormone (PTH) and reducing blood PTH levels. This compound holds the potential for researching secondary hyperparathyroidism (SHPT) [1].
T36919	1α-Hydroxy-3-epi-vitamin D3 1α-Hydroxy-3-epi-vitamin D3
	1α-Hydroxy-3-epi-vitamin D3, a natural metabolite derived from 1alpha,25-dihydroxyvitamin D3, effectively suppresses parathyroid hormone (PTH) secretion[1].
T39444	Upacicalcet sodium
	Upacicalcet (sodium) is an intravenous calcimimetic agent that acts directly on parathyroid cell membrane calcium-sensing receptors to suppress excessive parathyroid hormone (PTH) secretion, thereby lowering blood PTH levels. It is indicated for the research of secondary hyperparathyroidism (SHPT).
TP1906	DPC-AJ1951 DPC AJ1951
	Potent 14 amino acid peptide agonist of the parathyroid hormone (PTH) receptor (EC50 = 26 nM).
T76636	(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)
	'(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)'是用于甲状旁腺激素(PTH)受体的肽类配体。
TP1688	TIP 39, Tuberoinfundibular Neuropeptide
	This is a tuberoinfundibular neuropeptide and parathyroid hormone 2(PTH 2)-receptor agonist from hypothalmus. Synthetic TIP39 activates human and rat PTH2 receptors.
T81349	pTH-Related Protein (7-34) amide (human, mouse, rat)
	pTH-Related Protein (7-34) amide (human, mouse, rat) 为一种高效的甲状旁腺激素 (PTH) 拮抗剂。
T25455L	Glutaurine aceate	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	含有谷氨酰胺和牛磺酸残基的 Glutaurine aceate 是甲状旁腺的一种口服活性激素。Glutaurine 作为一种激素，从甲状旁腺嗜氧细胞中分离出来。Glutaurine 可用于抗癫痫和抗遗忘的研究。
T77991	Glutaurine TFA Litoralon TFA
	Glutaurine (Litoralon) TFA，含谷氨酰胺与牛磺酸残基，为甲状旁腺源嗜氧细胞分离的口服活性激素。该化合物在抗癫痫与抗健忘症研究中有应用。
T12363	Paricalcitol-D6	Others	Others
	Paricalcitol-D6 is the deuterated form of Paricalcitol, which is used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure.
T25234	CH5447240 CH 5447240,CH-5447240
	CH5447240 is an effective Human Parathyroid Hormone Receptor 1 (hPTHR1) Agonist for the treatment of Hypoparathyroidism. CH5447240 showed a potent in vitro hPTHR1 agonist effect (EC20: 3.0 nM; EC50: 12 nM). It showed 55% oral bioavailability and a signifi
T35524	(1S)-Calcitriol
	(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion[1]. 3‐epi‐Calcitroic acid is an end product of (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3; 3‐epi‐1a,25(OH)2D3) metabolism by rat CYP24A1[1]. [1]. Steve Y Rhieu, et al. Metabolic stability of 3-epi-1α,25-dihydr...
T35500	3-epi-25-hydroxy Vitamin D3 3-epi-25-hydroxy Vitamin D3
	3-epi-25-hydroxy Vitamin D3is the C-3 epimer of 25-hydroxy vitamin D3.1Dietary administration of 3-epi-25-hydroxy vitamin D3(0.5 and 1 IU/g) decreases levels of serum parathyroid hormone (PTH) in male, but not female, weanling rats. 1.Djekic-Ivankovic, M., Lavery, P., Agellon, S., et al.The C-3α epimer of 25-hydroxycholecalciferol from endogenous and exogenous sources supports normal growth and bone mineral density in weanling ratsJ. Nutr.147(2)141-151(2017)
T75272	Paricalcitol-d
	Paricalcitol-d6，是一种Paricalcitol的氘代物，主要用于治疗与慢性肾衰竭相关的继发性甲状旁腺机能亢进。
T81350	pTH-Related Protein (1-37) (human, mouse, rat)
	pTH-Related Protein (1-37) (human, mouse, rat) 为甲状旁腺相关蛋白 (pTHrP) 的肽段，涉及骨形成的生理调控过程。
T81591	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) Human PTHrP(107-111) amide
	Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat) (Human PTHrP (107-111) amide) 是一段具有抑制骨吸收作用的C端甲状旁腺激素相关蛋白片段。
T75942	DPC-AJ1951 TFA
	DPC-AJ1951 TFA，是一种含有14个氨基酸的肽类化合物，有效充当甲状旁腺激素(PTH)/PTH相关肽受体(PPR)激动剂，在体外及体内骨吸收实验中展现活性。
T73690	Abaloparatide
	Abaloparatide (BA 058) 是一种甲状旁腺激素受体 1 (PTHR1) 类似物。Abaloparatide 也是一种选择性 PTHR1激活剂。Abaloparatide 增强 Gs/cAMP 信号和β-arrestin 募集。Abaloparatide 可增强小鼠的骨形成和皮质结构。Abaloparatide 具有用于骨质疏松症研究的潜力。
T77990	Human PTHrP-(1-36)
	Human PTHrP-(1-36) 为PTHrP的分泌形式，具抗尿酸效应，并能促进β细胞功能与增殖。该化合物可应用于研究恶性肿瘤体液性高钙血症（HHM）及甲状旁腺功能亢进症。
T76649	Osteostatin (human)
	Osteostatin (human)，一种甲状旁腺激素相关蛋白(PTHrP) 107-139片段，可在骨缺损动物模型中促进骨修复并在炎症性关节炎中防止骨侵蚀。
T37409	DPC-AJ1951 (trifluoroacetate salt) DPC-AJ1951 (trifluoroacetate salt)
	DPC-AJ1951 is a peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR; EC50 = 0.15 nM in HEK293 cells expressing human PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). DPC-AJ1915 stimulates osteoclast-mediated bone resorption in fetal rat long-bone explant cultures and increases collagen synthesis and cell proliferation in neonatal mouse parietal bone explants...
T76660	pTH (1-37) (human)
	pTH (1-37) (human) 为甲状旁腺激素（PTH）的一段，能诱导cAMP产生并提升碱性磷酸酶活性，进而增强尿毒症动物的生长速度、骨钙含量及骨矿物质密度（BMD），显示出对骨质疏松症研究的应用潜力。
T83178	ACTH (6-24) (human) Adrenocorticotropic hormone (6-24)
	ACTH (6-24) (human)（腎上腺皮質激素（6-24））是腎上腺皮質激素的片段。該化合物作為ACTH (1-39) 和 ACTH (5-24) 引起的類固醇生成的競爭性抑制劑，具有相應的Kd值分別為13.4和3.4nM。此外，ACTH (6-24) (human) 能夠抑制 hPTH 1-34 所誘導的皮質酮產生以及cAMP的累積。
T73132	DS69910557
	DS69910557为高效、选择性的hPTHR1拮抗剂，口服有效。其对PTHR1的拮抗IC50值为0.08 μM。适用于甲状旁腺功能亢进症、恶性肿瘤引起的高钙血症及骨质疏松症研究。
T36385	Ansatrienin A
	Ansatrienin A is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis. In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 64 nM), which is a measure of bone resorption, and pp60c-srcM kinase (IC50 = 100 nM). It also inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1; IC50 = 570 nM). Early in vitro studies showed that ansatrienin A potentiates the chemotherapeutic action of 5-fl...
T76657	Human PTH-(1-31)
	Human PTH-(1-31) 是人PTH的第1至31个氨基酸片段。它能够促进cAMP的释放，并作为25-羟基维生素D-1α-羟化酶的弱激活剂。此外，Human PTH-(1-31) 能够促进骨生成，而不引起骨质吸收，表明其在骨质疏松症研究中的应用潜力。
T81592	Osteostatin PTHrP (107–111)
	Osteostatin为甲状旁腺激素相关蛋白(PTHrP) 107-111片段，该化合物在动物模型中促进骨缺损修复，预防炎症性关节炎引起的骨侵蚀，并抑制骨胶原诱导的关节炎及破骨细胞的吸收作用。Osteostatin主要应用于免疫炎症的研究领域。
T36650	Ansatrienin B
	Ansatrienin B is an ansamycin antibiotic and antifungal agent first isolated from S. collinus and S. rishiriensis., In fetal rat long bones, it is an inhibitor of parathyroid hormone-induced calcium release (IC50 = 21 nM), which is a measure of bone resorption, and pp60c-src kinase (IC50 = 50 nM). It is an inhibitor of translation at the protein synthesis stage by specific inhibition of L-leucine incorporation (IC50 = 58 nM in A549 cells). It also inhibits TNF-α-induced expression of intercellul...
T76663	pTH-Related Protein (1-40) (human, mouse, rat)
	pTH-Related Protein (1-40) (human, mouse, rat) 促进大鼠肠细胞通过PTHR1受体和PKCα/β信号通路的钙吸收作用。该蛋白增加了甲状旁腺激素1受体（PTHR1）表达，提升了四种跨膜钙转运蛋白—TRPV6、CaBP-D9k、NCX1和PMCA1的水平。
T83733	TIP39 (human, bovine) TFA Tuberoinfundibular Peptide of 39 Residues
	TIP39作为一种神经肽及甲状旁腺激素受体2型(PTH2R)激动剂，在表达重组人或大鼠PTH2R的COS-7细胞中诱导cAMP积累（EC50分别为0.5和0.8 nM），以及在内源性表达PTH2R的F-11细胞中（EC50 = 1.15 nM）。在CFK2大鼠软骨细胞中，TIP39 (1 nM)诱导细胞周期在G0/G1阶段停滞，并减少软骨分化的主要调控因子Sox9的表达。此外，TIP39 (100 pmol/动物)在小鼠强迫游泳测试中减少了不动时间。

化合物

Parathyroid hormone

Cat.No: T73692

Parathyroid Hormone (1-34), bovine

Cat.No: T21535

Target: Thyroid hormone receptor(THR)

Parathyroid Hormone (1-13) (trifluoroacetate salt)

Cat.No: T36767

Parathyroid hormone (1-34) (rat)

Cat.No: TP1964

parathyroid hormone (7-34) [Homo sapiens]/[Macaca fascicularis]

Cat.No: TP2283

Target: Others

Cat.No: T13128

Synonym: 特立帕肽,Human parathyroid hormone-(1-34),hPTH (1-34),PTH 1-34

Target: Others

Teriparatide acetate

Cat.No: T21460

Synonym: hPTH 1-34 (acetate salt),Parathar acetate,Forteo,醋酸立特帕肽

Target: Others

Parathyroid Hormone (1-34), human, biotinylated

Cat.No: T76084

Parathyroid hormone (1-34) (rat) acetate

Cat.No: T76061

Parathyroid Hormone (1-34), bovine TFA

Cat.No: T75867

Cinacalcet hydrochloride

Cat.No: T2406

Synonym: AMG-073 HCl,Cinacalcet HCl,AMG-073 hydrochloride,Cinacalcet,盐酸西那卡塞

Target: CaSR

Abaloparatide acetate(247062-33-5 free base)

Cat.No: TP1215L

Target: Others

Cat.No: T16015

Synonym: 马沙骨化醇,22-Oxacalcitriol

Target: Others

Abaloparatide TFA

Cat.No: TP1215

Synonym: BA 058 TFA,Abaloparatide TFA (247062-33-5 free base),BIM 44058 TFA

Target: Others

Cat.No: T29067

Synonym: PLS-240,SK-1403,AJT-240

Target: Calcium Channel

(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate

Cat.No: T9691L

Target: Thyroid hormone receptor(THR)

Etelcalcetide hydrochloride

Cat.No: TP1236

Synonym: AMG 416 hydrochloride,维考西肽盐酸盐,KAI-4169 hydrochloride

Target: CaSR

DPC AJ1951 acetate

Cat.No: TP1906L1

Target: Thyroid hormone receptor(THR)

Upacicalcet HCl

Cat.No: T29067L

Synonym: Upacicalcet HCl(1333218-50-0 Free base)

Target: CaSR

Calcium-Sensing Receptor Antagonists I

Cat.No: T10665

Target: Others

(Rac)-Upacicalcet

Cat.No: T61232

1α-Hydroxy-3-epi-vitamin D3

Cat.No: T36919

Synonym: 1α-Hydroxy-3-epi-vitamin D3

Upacicalcet sodium

Cat.No: T39444

Cat.No: TP1906

Synonym: DPC AJ1951

(Tyr36)-pTH-Related Protein (1-36) (human, mouse, rat)

Cat.No: T76636

TIP 39, Tuberoinfundibular Neuropeptide

Cat.No: TP1688

pTH-Related Protein (7-34) amide (human, mouse, rat)

Cat.No: T81349

Glutaurine aceate

Cat.No: T25455L

Target: Thyroid hormone receptor(THR)

Cat.No: T77991

Synonym: Litoralon TFA

Paricalcitol-D6

Cat.No: T12363

Target: Others

Cat.No: T25234

Synonym: CH 5447240,CH-5447240

(1S)-Calcitriol

Cat.No: T35524

3-epi-25-hydroxy Vitamin D3

Cat.No: T35500

Synonym: 3-epi-25-hydroxy Vitamin D3

Cat.No: T75272

pTH-Related Protein (1-37) (human, mouse, rat)

Cat.No: T81350

Osteostatin (1-5) amide (human, bovine, dog, horse, mouse, rabbit, rat)

Cat.No: T81591

Synonym: Human PTHrP(107-111) amide

Cat.No: T75942

Cat.No: T73690

Human PTHrP-(1-36)

Cat.No: T77990

Osteostatin (human)

Cat.No: T76649

DPC-AJ1951 (trifluoroacetate salt)

Cat.No: T37409

Synonym: DPC-AJ1951 (trifluoroacetate salt)

pTH (1-37) (human)

Cat.No: T76660

ACTH (6-24) (human)

Cat.No: T83178

Synonym: Adrenocorticotropic hormone (6-24)

Cat.No: T73132

Cat.No: T36385

Human PTH-(1-31)

Cat.No: T76657

Cat.No: T81592

Synonym: PTHrP (107–111)

Cat.No: T36650

pTH-Related Protein (1-40) (human, mouse, rat)

Cat.No: T76663

TIP39 (human, bovine) TFA

Cat.No: T83733

Synonym: Tuberoinfundibular Peptide of 39 Residues

Cat. No.	Product Name	Target	Signaling Pathways
T6316	Calcitriol Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3	Endogenous Metabolite	Metabolism
	Calcitriol (1,25-Dihydroxyvitamin D3) 是一种维他命 D 的代谢物，一种维他命 D 受体 (VDR) 的激动剂 (IC50=0.4 nM)。Calcitriol 增加肠道对钙和磷的吸收，并与甲状旁腺激素一起增加了骨吸收。
T16442	PCO371 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	PCO371 (2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-) 是口服具有活性的甲状旁腺激素受体 1 的完全激动剂，对 PTHR2 无作用

天然产物

Cat.No: T6316

Synonym: Topitriol,Rocaltrol,Calcijex,RO215535,骨化三醇,1,25-Dihydroxyvitamin D3

Target: Endogenous Metabolite

Cat.No: T16442

Synonym: 2,4-Imidazolidinedione, 1-(3,5-dimethyl-4-(2-((4-oxo-2-(4-(trifluoromethoxy)phenyl)-1,3,8-triazaspiro(4.5)dec-1-en-8-yl)sulfonyl)ethyl)phenyl)-5,5-dimethyl-

Target: Thyroid hormone receptor(THR)

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