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Cat. No.	Product Name	Target	Signaling Pathways
T7020	Z-VAD-FMK Z-VAD(OH)-FMK,Caspase Inhibitor VI,Z-VAD	Caspase	Apoptosis; Proteases/Proteasome
	Z-VAD-FMK (Caspase Inhibitor VI) 是一种 caspase 的广谱抑制剂，具有不可逆性。Z-VAD-FMK 与活化的 caspase 结合，从而抑制细胞凋亡。
T0282	Q-VD-OPH Quinoline-Val-Asp-Difluorophenoxymethylketone	Caspase; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Q-VD-OPH (Quinoline-Val-Asp-Difluorophenoxymethylketone) 是一种具有强效抗凋亡特性的泛半胱天冬酶抑制剂。它可抑制 HIV 感染，能透过血脑屏障。
T6826	Emricasan PF 03491390,恩利卡生,IDN-6556	Influenza Virus; Caspase	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Emricasan (IDN-6556) 是一种泛的 caspase 抑制剂，具有不可逆性。Emricasan 具有抗炎和抗凋亡活性，可以用于治疗感染和肝衰竭等。Emricasan 还可以抑制 Zika 病毒感染。
T21293	MX1013 MX 1013,MX-1013
	MX1013, a dipeptide pan-caspase inhibitor, inhibits caspase-1, -3, -6, -7, -8, and -9.
T80624	Ac-VAD-CHO Ac-Val-Ala-Asp-CHO	Caspase	Apoptosis; Proteases/Proteasome
	Ac-VAD-CHO (Ac-Val-Ala-Asp-CHO)是一款caspase抑制剂，能够阻止缺氧细胞内MMP的降解以及细胞色素c的释出。
T39586	Cantrixil TRX-E-002-1
	Cantrixil (TRX-E-002-1) is a second-generation super-benzopyran (SBP) compound, derived from TRX-E-002. It elicits an increase in phosphorylated c-Jun levels, leading to caspase-mediated apoptosis in ovarian cancer cells. Cantrixil exhibits potent pan anti-cancer activity against various cancer phenotypes.
T13445	(R)-Q-VD-OPh (R)-Quinoline-Val-Asp-Difluorophenoxymethylketone,(R)-QVD-OPH	Others	Others
	(R)-Q-VD-OPh is the less active enantiomer of Q-VD-OPha. Q-VD-OPha is an irreversible inhibitor of pan-caspase, with potent antiapoptotic properties.
T69200	CGP74514A
	CGP74514A is a CDK1 inhibitor with potential anticancer activity. In U937 cells, CGP74514A - induced apoptosis (5 microM) became apparent within 4 hr and approached 100% by 24 hr. The pan- caspase inhibitor Boc-fmk and the caspase-8 inhibitor lETD-fmk opposed CGP74514A -induced caspase-9 activation and PARP degradation, but not cytochrome c or Smac/DIABLO release. CGP74514A -mediated apoptosis was substantially blocked by ectopic expression of full-length Bel- 2, a loop-deleted mutant Bcl-2, and...
T75010	TD1092
	TD1092 是一种泛凋亡抑制蛋白 (IAP) 降解剂，可降解 cIAP1,cIAP2和 XIAP。TD1092 激活细胞凋亡蛋白酶 (apoptosis3/7)，并通过促进 IAP 降解，导致癌细胞凋亡 (apoptosis)。同时，TD1092 还能够阻断 TNFα介导的 NF-κB 信号通路，抑制 IKK，IkBα，p65，和 p38 的磷酸化。TD1092 可作为 PROTAC，用于癌症研究。