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Search Results for " oxadiazole "

19

抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T4604	HC-056456 HC 056456,3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide	Others	Others
	HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) 是一种有效但不完全选择性的 CatSper 通道阻断剂。它能够减慢 [Na+]i 上升(IC50:3 µM)。
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole	Parasite	Microbiology/Virology
	Antileishmanial agent-2 是一种基于 3-Br-isoxazoline 的疟原虫抑制剂恶性疟原虫（D10 和 W2 菌株）和利什曼原虫属。 (L. infantum 和 L.tropica) 前鞭毛体，IC50 为 0.035、0.058、3.5 和 7.5 μM。
T60038	5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole	Others	Others
	5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole 可用于合成杂环化合物抑制 HIF 通路活性。
T13928	Tioxazafen	Others; Parasite	Microbiology/Virology; Others
	Tioxazafen 是一种二取代的恶二唑，是一种广谱种子处理杀线虫剂，对玉米，大豆和棉花中的线虫有效。
T67321	2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole
	2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67321，CAS号为 15420-02-7。
T66967	Ethyl 5-(4-bromophenyl)-1,3,4-oxadiazole-2-carboxylate
	Ethyl 5-(4-bromophenyl)-1,3,4-oxadiazole-2-carboxylate 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66967，CAS号为 931760-32-6。
T66233	2-([1,1-Biphenyl]-4-yl)-5-phenyl-1,3,4-oxadiazole
	2-([1,1-Biphenyl]-4-yl)-5-phenyl-1,3,4-oxadiazole 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66233，CAS号为 852-38-0。
T37002	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)
	7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (SBD-F) is a thiol-reactive fluorogenic probe.1It has been used to quantify the levels of homocysteine, cysteine, and cysteamine in human plasma.2SBD-F displays excitation/emission maxima of 380/515 nm, respectively.1 1.Imai, K., Toyo’oka, T., and Watanabe, Y.A novel fluorogenic reagent for thiols: Ammonium 7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonateAnal. Biochem.128(2)471-473(1983) 2.Ichinose, S., Nakamura, M., Maeda, M., et al.A validated HPLC-fluoresc...
T33685	Nitrobenzoxadiazolealanine
	Nitrobenzoxadiazolealanine is a fluorescent dinitrophenyl analog.
T60487	DDO-7263	Nrf2	Immunology/Inflammation
	DDO-7263 是一种 1,2,4-Oxadiazole 衍生物，通过与 Rpn6 结合上调 Nrf2，从而阻断 26S 蛋白酶体的组装和随后Nrf2 的泛素化降解。DDO-7263 是一种有效的Nrf2激活剂，能够激活 Nrf2-ARE 信号通路并发挥抗炎活性。
T35108	Way 120744 Way120744,Way-120744
	Way 120744 is a new naphthyl 3h -1,2,3,5-oxadiazole 2-oxide.
T12793	(S)-BI 665915	Others	Others
	(S)-BI 665915 is an orally active inhibitor of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP)(IC50 of 1.7 nM for FLAP binding)..
T71882	Pifexole
	Pifexole is the 1,2,4-oxadiazole derivative. It has a similar profile of muscle-relaxant activity in animals to that of chlorzoxazone. In rats, pifexole is reported to be seven times more potent than chlorzoxazone in inhibition of strychnine-induced convulsions.
T35887	MBD
	MBD, a novel fluorescent probe (7-(p-Methoxybenzylamino)-4-nitrobenz-2,1,3-oxadiazole), is utilized to study the conformation of protein and nucleoprotein. Its application is extended to bacterial ribosomes, as well as bovine trypsinogen and trypsin. MBD exhibits significant fluorescence when it binds to the hydrophobic region of macromolecules [1][2].
T63027	Antibacterial agent 66
	Antibacterial agent 66 (Compound 6q) 是一种三氟甲基吡啶 1,3,4-恶二唑衍生物，对 Xanthomonas oryzae pv. oryzae (Xoo) 具有活性 (EC50: 7.2 μg/mL）。
T37465	CAY10742
	CAY10742 is an orally bioavailable oxadiazole antibiotic.1It is active against the Gram-positive bacteriaS. aureus,S. epidermidis,S. haemolyticus,B. cereus,B. licheniformis,E. faecalis, andE. faecium(MICs = 1-4 μg/ml), including laboratory strains and clinical isolates with varying degrees of resistance to methicillin, vancomycin, linezolid, and other antibiotics. CAY10742 (40 mg/kg) reduces the number of bacteria in mouse neutropenic thigh models of linezolid-sensitive or -resistant methicillin...
T80925	Tuberculosis inhibitor 12
	Tuberculosis inhibitor 12（compound 12）作为恶二唑衍生物，表现出对结核分枝杆菌的显著抑制作用。在7H9-Tw-OADC介质中，Tuberculosis inhibitor 12（20 μM）展现了82%的抑制率，而在相同条件下抑制率为78%。
T79353	P-gp/BCRP-IN-2
	P-gp/BCRP-IN-2（化合物15）为恶二唑衍生物，作为ABC转运蛋白P-glycoprotein（IC50：1.6 nM）及BCRP（IC50：600 nM）的双重抑制剂。该化合物增强了Doxorubicin针对耐药型人腺癌结肠癌细胞系HT29/DX及MDCK-MDR1细胞的抗增殖效果。
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...

化合物

Cat.No: T4604

Synonym: HC 056456,3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide

Target: Others

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

Cat.No: T9858

Target: Parasite

5-(5-methyl-1H-1,2,4-triazol-3-yl)-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole

Cat.No: T60038

Target: Others

Cat.No: T13928

Target: Others, Parasite

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Cat.No: T67321

Ethyl 5-(4-bromophenyl)-1,3,4-oxadiazole-2-carboxylate

Cat.No: T66967

2-([1,1-Biphenyl]-4-yl)-5-phenyl-1,3,4-oxadiazole

Cat.No: T66233

7-Fluoro-2,1,3-benzoxadiazole-4-sulfonate (ammonium salt)

Cat.No: T37002

Nitrobenzoxadiazolealanine

Cat.No: T33685

Cat.No: T60487

Target: Nrf2

Cat.No: T35108

Synonym: Way120744,Way-120744

Cat.No: T12793

Target: Others

Cat.No: T71882

Cat.No: T35887

Antibacterial agent 66

Cat.No: T63027

Cat.No: T37465

Tuberculosis inhibitor 12

Cat.No: T80925

Cat.No: T79353

Cat.No: T37832

Synonym: CAY10761

Cat. No.	Product Name	Target	Signaling Pathways
T81487	Phidianidine B
	Phidianidine B，一种海洋来源的1,2,4-恶二唑代谢物，具有显著的细胞毒性。该化合物作为天然产物，可以从海洋软体动物中分离得到。

天然产物

Cat.No: T81487

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