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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T21588 |
Olomoucine
|
ERK; CDK | Cell Cycle/Checkpoint; MAPK |
Olomoucine 是 Cdk2/cyclin A、Cdc2/CyclinB、CDK2/CyclinE、CDK5/p35 和 ERK1/p44 MAP 激酶的 ATP 竞争性抑制剂,IC50 分别为 7、7、7、3 和 25 µM。 Olomoucine 调节细胞周期并表现出抗黑色素肿瘤活性。 | |||
T68468 |
FJ9
|
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FJ9 is a FZD7 inhibitor which disrupts protein-protein interaction between Frz7 and the PDZ domain of DVL, and induces apoptosis in melanoma cell line and non-small cell lung cancer cell line. | |||
T73244 |
NSD3-IN-3
|
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NSD3-IN-3,一种高效的NSD3抑制剂 (IC50=1.86 μM),对非小细胞肺癌细胞系H460的生长和增殖具有显著的抑制作用,表现出抗癌活性。 | |||
T63556 | EGFR-IN-59 | ||
EGFR-IN-59 是 EGFR 抑制剂,其IC50值为190 nM,也是一直凋亡 (apoptosis) 诱导剂。EGFR-IN-59 对非小肺癌细胞系 (A549) 和正常肺成纤维细胞 (WI38) 表现出细胞毒性的IC50分别为 8.62 和 52.6 μM。EGFR-IN-59 能够用于研究非小细胞肺癌 (NSCLC)、头颈癌、乳腺癌和结直肠癌等多种癌症。 | |||
T71549 |
RKS-262
|
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RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line assay RKS262 exhibited significant cytotoxicity in ovarian cancer cells and a variety of other cell lines exceeding effects of commercial drugs such as cisplatin, 5-FU, cyclophosphamide or sapacitabine. Various leukemia cell-lines were most sensitive (GI(50): ~ 10 nM) while several... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN3355 | Agatharesinol acetonide | Antifection | Microbiology/Virology |
Agatharesinol acetonide shows anticancer activity towards the A549 non-small-cell lung-cancer cell line (IC50 = 27.1 microM). | |||
TN1872 |
Linderone
|
Others | Others |
Linderone A shows anticancer activity against A549 non-small cell lung cancer cells and PC-3 prostate adenocarcinoma cell line. |