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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40101	(±)-1,2-Diolein 1,2-Dioleoyl-rac-glycerol,甘油1,2-二油酸酯	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) 是一种PKC 激活剂，可以增加肌小管 Ca2+内流。
T77697	BML-278 BML278,BML 278	Sirtuin; Histone Methyltransferase	Chromatin/Epigenetic; DNA Damage/DNA Repair
	BML-278 是一种 SIRT1 激活剂，EC150 值为 1 μM。BML-278 增加父本和母本原核中的 H3K9 甲基化并抑制 H3K9 乙酰化，可用于改善早期胚胎发育。BML-278 促使原代人间充质细胞的细胞周期停止在 G1/S 期，可用于延缓衰老。BML-278 减少 U937 细胞中的微管蛋白乙酰化，增加小鼠 C2C12 成肌细胞的线粒体密度。
T33764	NVS-SM2
	NVS-SM2 is an effective small molecule splicing enhancer of SMN2 with oral activity. NVS-SM2 showed increased exon 7 inclusion and upregulated SMN protein expression in SMA fibroblasts and SMN cells Δ7 5025 mouse myoblasts.
T78703	PTP1B/AKR1B1-IN-2	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-2（化合物7f）是一种双重PTP1B/AKR1B1抑制剂，具有IC50：3.2和2.1 μM，Ki：4.0和0.9μM。该化合物作为胰岛素模拟剂，能够改善小鼠C2C12肌母细胞的葡萄糖摄取，并可用于2型糖尿病（T2DM）的研究。
T36003	1(R)-(Trifluoromethyl)oleyl alcohol
	1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ...
T78702	PTP1B/AKR1B1-IN-1	Phosphatase	Metabolism
	PTP1B/AKR1B1-IN-1是一种针对PTP1B和AKR1B1的双重抑制剂，其IC50值分别为0.06 μM和4.3 μM。该化合物也能抑制TC-PTP，IC50为9 μM。在小鼠成肌细胞中，PTP1B/AKR1B1-IN-1作为胰岛素模拟剂使用，并能减少AKR1B1依赖的山梨醇积累，有助于抑制2型糖尿病的发展并控制血糖水平。
T36130	22(S)-hydroxy Cholesterol 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol
	22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22...
T36490	AZT triphosphate TEA
	AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in ...

化合物

(±)-1,2-Diolein

Cat.No: T40101

Synonym: 1,2-Dioleoyl-rac-glycerol,甘油1,2-二油酸酯

Target: PKC

BML-278

Cat.No: T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Target: Phosphatase

1(R)-(Trifluoromethyl)oleyl alcohol

Target: Phosphatase

22(S)-hydroxy Cholesterol

Cat.No: T36130

Synonym: 22(S)-hydroxy Cholesterol,22β-hydroxy Cholesterol

Cat. No.	Product Name	Target	Signaling Pathways
T74199	Beauverolide Ka
	Beauverolide Ka 是一种环四缩酚肽，是 Beauveria bassiana 真菌的代谢产物。Beauverolide Ka 浓度为 50 μM 时可刺激培养的大鼠 L6 成肌细胞的葡萄糖摄取。Beauverolide Ka 在 10 μM 时表现出对 HEI-OC1 细胞的保护作用，并且在 L6 成肌细胞和肌管中表现出剂量依赖性活性。

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