9
2
Cat. No. | Product Name | Target | Signaling Pathways |
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T8550 |
NDMC101
|
Others; NF-κB; Proteasome | NF-κB; Others; Proteases/Proteasome; Ubiquitination |
NDMC101 是有效的破骨细胞形成抑制剂,通过下调 NFATc1 调控基因表达抑制破骨细胞分化。它与 DPP4底物相似,通过抑制DPP4抑制早期 T 细胞激活。它能够用于骨疾病的研究,如类风湿关节炎、滑膜炎等。 | |||
T36260 | NR 7h | ||
Potent and selective p38α and p38β degrader (DC50 < 50 nM). Displays no significant degradation of p38γ, p38δ, JNK1/2 or ERK1/2. Inhibits phosphorylation of MK2 in UV-treated cancer cells and LPS-stimulated bone marrow-derived macrophages (BMDM). Exhibits similar effect to p38α gene knockout in BBL358 cells. Active in vivo. | |||
T37907 | DL 175 | ||
Potent and selective GPR84 biased agonist (EC50 = 33 nM). Exhibits no significant activity in a panel of 168 other GPCRs. Exhibits bias for G protein signaling pathways. Induces morphological changes in primary murine bone marrow-derived macrophages (BMDMs) in a cellular impedance assay, and promotes phagocytosis by M1 polarized U937 cells. Induces migration of primary human monocytes, but has no effect on macrophage chemotaxis. | |||
TP1978 |
11R-VIVIT
NFAT inhibitor, Cell Permeable |
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NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Improves symptoms in a mouse | |||
T9655 |
NBC 6
|
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NLRP3-IN-NBC6 是一种有效的选择性 NLRP3炎性小体抑制剂 ,IC50为574 nM,其作用独立于 Ca2+。NLRP3-IN-NBC6 抑制 Nigericin 诱导的 THP-1 细胞炎症反应和 Imiquimod 诱导的 LPS-primed 的骨髓源性巨噬细胞 (BMDMs) 释放 IL-1β。 | |||
T38309 |
LL-37 amide (trifluoroacetate salt)
|
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LL-37 is a cationic and α-helical antimicrobial peptide expressed in human bone marrow, testis, granulocytes, and gingival epithelium and is upregulated in psoriatic lesions. It inhibits growth of Gram-positive E. coli D21 and Gram-negative B. megatarium in a concentration-dependent manner and LL-37 expression is induced in A549 epithelial cells, alveolar macrophages, neutrophils, and monocyte-derived macrophages following M. tuberculosis infection. LL-37 binds sheep erythrocytes coated with S. ... | |||
T37166 |
RCTR1
|
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Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1It has been found in human spleen and bone marrow.2RCTR1 is produced via lipoxygenase-mediated oxidation of DHA to 7(S)-8-epoxy-17(S)-HDHA, which is conjugated to glutathione.1,2,3RCTR1 (10 nM) increases phagocytosis ofE. colior apoptotic neutrophils in isolated human monocyte-de... | |||
T36984 |
Cyclic di-IMP (sodium salt)
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Cyclic di-IMP (sodium salt) (c-di-IMP) is a synthetic second messenger structurally related to the bacterial second messengers cyclic di-GMP and cyclic di-AMP . C-di-IMP has adjuvant properties when co-administered with antigens in vitro and by mucosal routes in vivo. C-di-IMP enriches the population of MHC class I and II, CD80, CD86, CD40, and CD54 positive dendritic cells derived from murine bone marrow. It also stimulates macrophages at 500 ng/ml. Mice immunized with β-galactosidase (β-gal) p... | |||
TP1978L1 |
11R-VIVIT TFA (592517-80-1 Free base)
|
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11R-VIVIT TFA (592517-80-1 Free base) 是一种 NFAT 抑制剂。 11R-VIVIT TFA 抑制 LPS 或 LPS 加 IFN-γ 诱导的骨髓源性巨噬细胞 (BMDM) 分泌 IL-12 p40、IL-12 p70、IL-23 和 TNF。 11R-VIVIT TFA 减弱 LPS 刺激的 BMDM 中 NO 的产生和 Nos2 mRNA 的表达。 11R-VIVIT TFA 改善结肠炎小鼠模型的症状。 11R-VIVIT TFA 表现出免疫抑制作用并提高小鼠移植物的存活率。 11R-VIVIT TFA 具有细胞渗透性。 |
Cat. No. | Product Name | Target | Signaling Pathways |
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TN3209 |
3′,4′,7-Trihydroxyflavone
|
ATPase; Others; p38 MAPK; NF-κB | MAPK; Membrane transporter/Ion channel; NF-κB; Others |
3',4',7-Trihydroxyflavone 是分离自蚕豆荚的黄酮苷元化合物。 | |||
TN1484 |
Cheilanthifoline
|
NF-κB; Antifection | Microbiology/Virology; NF-κB |
Cheilanthifoline has anti-osteoclastogenic property, it gives significant inhibitions on receptor activator of nuclear factor-κB ligand-induced differentiation of mouse bone marrow-derived macrophages into multinucleated osteoclasts. |